William A. Newton

Parker Hannifin (United States)

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Harold M. Maurer

University of Nebraska Medical Center

Melvin Tefft

Williams & Associates

R. Beverly Raney

The University of Texas MD Anderson Cancer Center

Ala B. Hamoudi

Children's Oncology Group

Walter Lawrence

University of Iowa

Mohan Beltangady

Pfizer (United States)

Daniel M. Hays

Children's Hospital of Los Angeles

Ruth Heyn

Mayo Clinic

Abdelsalam H. Ragab

Mansoura University

Frederick B. Ruymann

Nationwide Children's Hospital

Cooperative Institutions

The Ohio State University

Nationwide Children's Hospital

University of Southern California

Children's Oncology Group

The University of Texas MD Anderson Cancer Center

National Cancer Institute

National Institutes of Health

St. Jude Children's Research Hospital

Dana-Farber Cancer Institute

Mayo Clinic

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Combined therapy in childhood rhabdomyosarcoma: An analysis of 42 cases

Journal of Pediatric Surgery (1969)

Jay L. Grosfeld H. William Clatworthy William A. Newton

Alveolar rhabdomyosarcoma

Combination chemotherapy

10.1016/0022-3468(69)90491-6

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Citations (78)

Renal toxicity of ifosfamide in pilot regimens of the intergroup rhabdomyosarcoma study for patients with gross residual tumor.

PubMed (1994)

Beverly Raney Lisa G. Ensign Jessica T. Foreman Fareed Khan William A. Newton

The purpose of this review is to characterize the nephrotoxicity noted in newly diagnosed patients under 21 years of age after treatment with ifosfamide-containing chemotherapy regimens and local irradiation for localized gross residual rhabdomyosarcoma or undifferentiated sarcoma.From 1987 to 1991, 194 previously untreated patients received vincristine and ifosfamide plus dactinomycin or etoposide for 1-2 years. Ifosfamide was given at 1.8 g/m2/day for 5 days with sodium mercaptoethane sulfonate, or 9 g/m2 of ifosfamide per course. The three-drug regimen was repeated every 3-4 weeks.Twenty-eight patients (14%) developed renal toxicity: 19 had renal tubular dysfunction (RTD) characterized by low serum phosphate (< or = 3 mg/dl) or bicarbonate (< 20 or = mEq/L) levels, five had decreased glomerular function (DGF), and four had both RTD and DGF. When nine or more courses of ifosfamide (> 72 g/m2) were given, children < 3 years of age had a higher incidence of RTD than did children > or = 3 years of age (34% versus 6%; p < 0.001). A similar age difference was observed even when eight or fewer courses (< or = 72 g/m2) were given (p = 0.03). A matched case-control comparison showed that renal abnormalities at diagnosis, chiefly hydronephrosis, also increased the risk of renal tubular injury by ifosfamide by a factor of 13 (p < 0.001). Patients with DGF tended to be older than those with RTD, and all but one received > 72 g/m2 of ifosfamide.Patients who are < 3 years of age who receive more than eight courses (> 72 g/m2) of ifosfamide and who have a preexisting renal abnormality have an increased risk of RTD and DGF. The renal function of patients being considered for ifosfamide treatment must be carefully monitored. Ifosfamide should be avoided in patients with renal abnormalities at diagnosis unless the potential benefit clearly exceeds the risk of further renal impairment.

Nephrotoxicity

Mesna

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A Late Diagnosis of Transthyretin Amyloidosis

Cureus (2022)

Kristopher S. Pfirman William A. Newton Collins Garst Sharvil Patel Jacqueline Dawson Dowe

Cardiac amyloidosis is a rare disease caused by the accumulation of protein-based fibrils that deposit into the myocardium, causing disease. The accumulation of amyloid in the heart tissue causes the heart to become increasingly stiff, reducing compliance, with the eventual decline of the heart's systolic function over time as the disease progresses. The restrictive physiology of the disease usually prompts investigation; however, if allowed to progress, the systolic function becomes affected in the later stages of the disease. We present a case of late-stage transthyretin-related amyloidosis (ATTR).

Cardiac Amyloidosis

Amyloid (mycology)

10.7759/cureus.21481

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Undifferentiated sarcomas of children: Pathology and clinical behavior—an Intergroup Rhabdomyosarcoma Study

Medical and Pediatric Oncology (1997)

Bruce Pawel Ala B. Hamoudi Lina Asmar William A. Newton Frederick B. Ruymann

Undifferentiated soft tissue sarcoma (UND-STS) is the most poorly defined tumor eligible for Intergroup Rhabdomyosarcoma Studies (IRS). Recent IRS UND-STS experience was reviewed to assess the histologic characteristics and clinical behavior of undifferentiated sarcomas. Of the 1,527 patients entered on IRS-III and IRS pilot-IV, 96 had tumors classified by the IRS Pathology Committee as UND-STS. Of these, 52 had adequate histologic material for this study. After application of immunohistochemistry, 18 tumors were reclassified, mostly as embryonal rhabdomyosarcomas (RMS), primitive neuroectodermal tumors, and intra-abdominal desmoplastic small round cell tumors. The remaining 34 UND-STS had a diffuse hypercellular histologic pattern made up of sheets of medium-sized cells. The tumor cells had a minimal to moderate amount of cytoplasm and a variable nuclear morphology, predominately vesicular with finely granular chromatin. Except for reactivity with antibodies against vimentin, most tumors had a negative immunohistochemical profile. The 5 year Kaplan-Meier survival estimate for patients with non-metastatic disease was 72%, a significant improvement when contrasted with patients diagnosed to have UND-STS in IRS-I and IRS-II. Med. Pediatr. Oncol. 29:170–180, 1997. © 1997 Wiley-Liss, Inc.

10.1002/(sici)1096-911x(199709)29:3<170::aid-mpo3>3.3.co;2-5

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Citations (2)

Persistent jaundice in infancy

The Journal of Pediatrics (1962)

Robert L. Brent James B. Arey William A. Blanc John M. Craig Sydney S. Gellis

10.1016/s0022-3476(62)80238-8

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Citations (71)

Anti-M Antibody as a Cause of Intrauterine Death. Report of Two Stillbirths Resulting from Anti-M Antibody

American Journal of Clinical Pathology (1961)

Colin R. Macpherson Mara J. Christiansen William A. Newton Edwin R. Zartman

Journal Article Anti-M Antibody as a Cause of Intrauterine Death. Report of Two Stillbirths Resulting from Anti-M Antibody. Get access C.R. Macpherson, M.D., C.R. Macpherson, M.D. Departments of Pathology, Pediatrics, and Obstetrics, Ohio State University, College of Medicine, Columbus, Ohio Search for other works by this author on: Oxford Academic Google Scholar Mara J. Christiansen, M.T. (ASCP), Mara J. Christiansen, M.T. (ASCP) Departments of Pathology, Pediatrics, and Obstetrics, Ohio State University, College of Medicine, Columbus, Ohio Search for other works by this author on: Oxford Academic Google Scholar William A. Newton, Jr, M.D., William A. Newton, Jr, M.D. Departments of Pathology, Pediatrics, and Obstetrics, Ohio State University, College of Medicine, Columbus, Ohio Search for other works by this author on: Oxford Academic Google Scholar Edwin R. Zartman, M.D. Edwin R. Zartman, M.D. Departments of Pathology, Pediatrics, and Obstetrics, Ohio State University, College of Medicine, Columbus, Ohio Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 35, Issue 1, 1 January 1961, Pages 31–35, https://doi.org/10.1093/ajcp/35.1.31 Published: 01 January 1961 Article history Received: 01 April 1960 Revision received: 28 July 1960 Accepted: 01 September 1960 Published: 01 January 1961

10.1093/ajcp/35.1.31

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Citations (11)

Prenatal Chlordane Exposure and Neuroblastoma

New England Journal of Medicine (1975)

Peter F. Infante William A. Newton

Chlordane

10.1056/nejm197508072930625

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Citations (15)

Suppressor-cell dysfunction in children with histiocytosis-X

Journal of Clinical Immunology (1986)

Barry T. Shannon William A. Newton

10.1007/bf00915257

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Citations (23)

Orthostatic Hypotension

New England Journal of Medicine (1977)

Inta J. Ertel E. Thomas Boles William A. Newton

10.1056/nejm197705192962020

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Citations (26)

Orbital rhabdomyosarcomas and related tumors in childhood: Relationship of morphology to prognosis—an intergroup rhabdomyosarcoma study

Medical and Pediatric Oncology (1997)

Roman Kodet William A. Newton Ala B. Hamoudi Lina Asmar Moody D. Wharam

Children and adolescents who develop rhabdomyosarcoma (RMS) and related sarcomas in the orbit and treated on Intergroup Rhabdomyosarcoma protocols have had an extremely high cure rate. This study evaluates the possible relationship between their tumor morphologic subtypes and this high cure rate. The histology of tumors was re-reviewed from 229 of the 264 patients with tumors of the orbit, conjunctiva, and eyelids treated on Intergroup Rhabdomyosarcoma Studies (IRS) I, II, III, and IV pilot protocols, and followed through July, 1992. Immunohistochemistry was applied in selected cases. Clinical correlations were done on all 264 cases including both the re-reviewed cases and those reviewed only by the IRS Pathology committee. The 5-year survival rate of 24 children with alveolar RMS was 74% (p < .001). All five infants diagnosed to have an alveolar RMS died before the age of one. Two hundred and twenty-one patients (84%) had embryonal RMS. About three-fourths of the re-reviewed embryonal RMS tumors showed only minimal rhabdomyoblastic differentiation. Thirty-one had a spindle cell RMS, two were anaplastic variants. The 5-year survival rate for patients with embryonal RMS subtypes combined was 94%, and 97% for the 144 patients with poorly differentiated embryonal RMS. In contrast, 190 of 432 IRS II patients treated for poorly differentiated embryonal RMS located in extraocular sites had a 66% survival estimate. Med. Pediatr. Oncol. 29:51–60, 1997. © 1997 Wiley-Liss, Inc.

Embryonal rhabdomyosarcoma

Histology

Alveolar rhabdomyosarcoma

10.1002/(sici)1096-911x(199707)29:1<51::aid-mpo10>3.0.co;2-7

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Citations (84)