Amir Shahram Yousefi Kashi

Shahid Beheshti University of Medical Sciences

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Afshin Rakhsha

Shahid Beheshti University of Medical Sciences

Farzad Taghizadeh‐Hesary

Iran University of Medical Sciences

Bahram Mofid

Shahid Beheshti University of Medical Sciences

Mohammad Houshyari

Shahid Beheshti University of Medical Sciences

Ahmad Ameri

Shahid Beheshti University of Medical Sciences

Abolfazl Razzaghdoust

Shahid Beheshti University of Medical Sciences

Hossein Rezaeizadeh

Tehran University of Medical Sciences

Samira Azghandi

Shahid Beheshti University of Medical Sciences

Rama Bozorgmehr

Shahid Beheshti University of Medical Sciences

Farshid Farhan

Tehran University of Medical Sciences

Cooperative Institutions

Shahid Beheshti University of Medical Sciences

Shahid Beheshti University

Tehran University of Medical Sciences

Imam Hossein Hospital

Iran University of Medical Sciences

University of Tehran

Shiraz University of Medical Sciences

Roozbeh Hospital

HCA Healthcare

University of Houston

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Radiation-induced Stromal Sarcoma of Breast: A Case Report and Literature Review

International Journal of Cancer Management (2021)

Amir Shahram Yousefi Kashi Farzad Taghizadeh‐Hesary

Introduction: Post-irradiation mammary stromal sarcoma (MSS) is a rare condition, and it is worth learning new knowledge from each case. Case Presentation: We present the case report of a 59-year-old female with a medical history of breast cancer, who presented with an axillary mass on the same side. The patient was further evaluated and finally diagnosed with MSS with chondroid differentiation. Thereafter, she underwent neoadjuvant chemotherapy to facilitate the surgical resection of the tumor. However, she experienced local progression and lung metastasis during chemotherapy. Conclusions: MSS with chondroid differentiation was resistant to the standard chemotherapy regimens of sarcoma. Radiotherapy is a potential choice in the case of chemoresistant MSS. Further trials may reveal this notion.

Presentation (obstetrics)

Case presentation

Undifferentiated Pleomorphic Sarcoma

Stromal tumor

10.5812/ijcm.107295

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Citations (2)

Low-Dose Whole-Lung Irradiation for COVID-19 Pneumonia: Short Course Results

International Journal of Radiation Oncology*Biology*Physics (2020)

Ahmad Ameri Nazanin Rahnama Rama Bozorgmehr Majid Mokhtari Mohammad Farahbakhsh

Pneumonitis

10.1016/j.ijrobp.2020.07.026

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Citations (69)

Clinical effectiveness of combined whole body hyperthermia and external beam radiation therapy (EBRT) versus EBRT alone in patients with painful bony metastases: A phase III clinical trial study

Journal of Thermal Biology (2024)

Fahimeh Faghihi Moghaddam Mohsen Bakhshandeh Bahram Mofid Hüseyin Sahinbas Fariborz Faeghi

External beam radiation

External beam radiotherapy

10.1016/j.jtherbio.2024.103804

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Citations (1)

51: Preventive Effect of Malva on Urinary Toxicity after Radiation Therapy in Prostate Cancer Patients: A Multicentric, Double-Blind, Randomized Clinical Trial

Radiotherapy and Oncology (2016)

Amir Shahram Yousefi Kashi Bahram Mofid Hossein Rezaeizadeh Amir Mohammad Jaladat Fatemeh Atarzadeh

The Cancer of the Prostate Risk Assessment Postsurgical Score (CAPRA-S) can predict for recurrence and mortality post radical prostatectomy (RP) with a c-index > 0.70.We evaluated its predictive value for patients treated with RP followed by subsequent external beam radiotherapy (EBRT).Methods and Materials: A total of 373 patients were identified in the institutional database who were treated with EBRT between January 2000 and June 2015.Follow up and complete CAPRA-S score were available for 334 (89.5%) patients.CAPRA-S scores were sorted into previously defined categories of low-(score 0-2), intermediate-(3-5), and high-risk (6-12).Time to biochemical recurrence (BCR) was defined as PSA > 0.20 ng/mL after EBRT.Survival analyses were performed using the Kaplan-Meier method and comparisons were made using the log-rank test.Results: Median age at time of EBRT was 64 years (IQR: 59-68).Median time from RP to EBRT was 18 months (IQR: 8-36).Median dose was 66 Gy (range 64-70 Gy) and median follow up following EBRT was 48 months (IQR: 28-78).In 65%, the PSA before EBRT was ≤ 0.5 ng/mL.Twenty-two (6.6%) patients died during follow up, nine from metastatic prostate cancer.84.3% of patients were classified as intermediate-or high-risk in the CAPRA-S grouping system.Concomitant androgen deprivation therapy (ADT) was administered in 36% for a median of nine months.CAPRA-S as a categorical variable (low-, intermediate-, high-risk group) was predictive of time to BCR (p < 0.001) and time to palliative ADT (p = 0.017) and borderline significant (p = 0.058) of overall survival.On multivariate analysis, the CAPRA-S was predictive of time to BCR only (low-risk versus intermediate-risk; HR 0.14, 95% CI0.043-0.48,p = 0.001).When looking only at the CAPRA-S highrisk group, overall survival at five and 10 years were 90% and 83%, respectively.After five years, 62% had not received ADT for recurrence and at 10 years, 47%.The last PSA value before EBRT as a continuous and grouped variable proved highly significant in predicting all outcomes tested, including OS (p ≤ 0.002). Conclusions:We present the first Canadian data on postoperative EBRT.Together with the PSA before EBRT, CAPRA-S is a useful tool to predict time to palliative ADT, and was borderline significant for OS.Our results emphasize the importance of a low PSA before EBRT and the fact that EBRT is effective in avoiding ADT even in patients with several high-risk features.

10.1016/s0167-8140(16)33450-8

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Citations (0)

Overall survival and related prognostic factors for familial breast cancer patients: A single institution study in Iran

The Breast Journal (2020)

Amir Shahram Yousefi Kashi

Shahid

Research center

10.1111/tbj.13942

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Citations (1)

Intracyctic Papillary Carcinoma of the Breast: Report of a Rare Case and Literature Review

International Journal of Cancer Management (2017)

Nafiseh Mortazavi Kambiz Novin Farahnaz Bidari Zerehpoosh Amir Shahram Yousefi Kashi Managol Sadatsafavi

Introduction: We present a rare case of breast papillary carcinoma associated with intracystic component in a woman with a long history of autoimmune hypothyroidism and multiple sclerosis. Case Presentation: The patient was a 59-year-old woman presented with complaints of pain and swelling in her right breast. She was a known case of autoimmune hypothyroidism since 20 years and secondary progressive multiple sclerosis since 13 years ago. She had received frequent interferon, corticosteroid and cytotoxic therapy for her multiple sclerosis. On imaging studies, there were multiple large cystic-solid lesions in the right breast and with presumptive diagnosis of infectious collection or phyllodes tumor, she finally underwent simple mastectomy. On gross pathological evaluation, a large multi-loculated cyst filled with blood clots and necrotic debris was identified. In serial sections, a 7 cm solid tumoral mass with papillary projections protruding into the cyst cavity was seen. Although the gross appearance of the lesion resembled an angiosarcoma accompanied by cystic hemorrhagic necrosis, after the microscopic evaluation of the specimen, papillary breast carcinoma associated with intracyctic component was finally diagnosed. Conclusions: The aim of this study was to describe a rare variant of invasive breast cancer presenting with a large solid-cyctic mass in a woman with long standing autoimmune disorders.

Gross examination

10.5812/ijcm.7259

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Citations (2)

Clinical Outcome and Prognostic Factors in Iranian Breast Cancer Patients After Neoadjuvant Chemotherapy: A Comparative Matched Study

International Journal of Cancer Management (2018)

Amir Shahram Yousefi Kashi Rezvan Montazeri Afshin Rakhsha

Background: Breast cancer is the most frequent diagnosed solid cancer with the incidence rate of 32 patients in 100,000 among Iranian women. Neo-adjuvant chemotherapy (NAC) is the standard treatment for patients with locally advanced breast cancer, which was recently introduced for early stage disease to achieve breast preservation. Objectives: The aim of this study was to evaluate the rate of local recurrence, distant recurrence, breast cancer mortality, five years disease free survival (DFS) and five years overall survival (OS) in patients with breast cancer after NAC and to compare these factors with patients, who received adjuvant chemotherapy. Methods: In this cross sectional study, 188 patients with stage I to III breast cancer, who received NAC (group A), and 376 patients with breast cancer, who received adjuvant chemotherapy (group B), were selected and matched based on a time- stratified 2:1 approach between October 2002 and December 2014. Their clinical-pathological profile and survival study were compared. Results: The mean age of patients was 48.23 years in group A and 48.76 years in group B. The median follow-up time was 52 months. In group A and group B, 13.1% and 7.7% of the patients had local recurrence during the five years of follow up, respectively (P < 0.001). In group A and group B, five years PFS rate and five years OS rate was 66% and 70%, and 81.8% and 82.6%, respectively. According to log-rank test analysis, there was no significant difference between two groups as five years DFS and five years OS (P = 0.058 and P = 0.98, respectively). Conclusions: This study showed that higher frequency of local recurrence in NAC group than adjuvant chemotherapy group was not associated with any significant increase in distant recurrence or breast cancer mortality. Longer follow-up time of the patients to compare survival between two groups is recommended.

Group B

10.5812/ijcm.67739

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Citations (7)

Clinical Outcome and Prognostic Factors for Nasopharyngeal Carcinoma: A Single Institution Study in Iran

International Journal of Cancer Management (2017)

Ahmad Ameri Nafiseh Mortazavi Amir Shahram Yousefi Kashi Kambiz Novin

Background: Evidence about survival of the patients with nasopharyngeal cancer is scant in our region and the aim of the current study was to determine clinico-pathological factors influencing outcome of these patients. Methods: We reviewed all patients with a new diagnosis of nasopharyngeal carcinoma admitted between 2008 and 2014 to Jorjani cancer center, Tehran, Iran. Overall survival (OS) of the patients and their relation with demographic and clinico-pathological factors were analyzed. Results: Of 88 included patients, 56 were male and 32 were female with mean age of 46 years. With a median follow-up period of 31 months (range: 3 to 86 months), the overall survival of the whole patients and those without distant metastasis were 64% and 67% respectively. Tumor stage and presence or absence of distant metastasis at presentation were the only parameters that significantly influenced the patientsâ OS. Conclusions: Our study provides some evidence on the outcome of Iranian patients with nasopharyngeal cancer and factors influencing it.

Distant metastasis

10.5812/ijcm.5846

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A Comparative Matched Study of Breast-Conserving Therapy and Modified Radical Mastectomy in Iranian Women

International Journal of Cancer Management (2019)

Mohammad Houshyari Afshin Rakhsha Mohammadreza Khademi Amir Shahram Yousefi Kashi

Background: Breast cancer is the most frequent diagnosed visceral cancer with 13400 new cases annually among Iranian women. Modified radical mastectomy (MRM) was the old standard surgical treatment in patients with breast cancer from 70 years ago and breast-conserving surgery (BCS) with adjuvant radiotherapy was the standard treatment from 30 years ago. Objectives: In this matched historical cohort study, we compared two types of therapy for breast carcinoma: breast-conserving therapy (BCT), and MRM. Methods: Medical records of 6000 patients with breast cancer from the database of Cancer Research Center of Shahid Beheshti University of Medical Sciences were reviewed and 1310 patients who had been treated by BCT (group A) or MRM (group B) were selected based on a time- stratified 1:1 between September 2002 and December 2014 as 10 baseline variables. By log-rank test analysis, their local recurrence (LR), disease free survival (DFS) and overall survival (OS) were evaluated and compared. Results: In groups A and B, the median age at the diagnosis time was 48.11 and 48.64 years old, respectively. Median follow-up time was 71 months since April 2015. 1.68% of patients in group A and 1.07% of patients in group B had local recurrence during the five years of follow up, (P = 0.173). In the group A and B, five years DFS were 87.94% and 80.46%, (P < 0.001) and five years OS were 89.31% and 83.02%, respectively (P = 0.041). Conclusions: The findings of this study showed that 5-year DFS and 5-year OS in BCT group were better than in the MRM group. Longer follow-up time of the patients to compare 10-year DFS and 10-year OS or even 20-year OS between two groups is recommended.

Modified Radical Mastectomy

Breast-conserving surgery

Adjuvant Therapy

Shahid

Radical mastectomy

10.5812/ijcm.92798

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Citations (1)

Preventive effect of Malva on urinary toxicity after radiation therapy in prostate cancer patients: A multi-centric, double-blind, randomized clinical trial.

PubMed (2015)

Bahram Mofid Hossein Rezaeizadeh Amir Mohammad Jaladat Fatemeh Atarzadeh Reihaneh Moeini

For patients receiving external beam radiation therapy (EBRT) after radical prostatectomy as adjuvant treatment or patients receiving EBRT as definitive treatment, partial irradiation of the urinary bladder is common. Many of such patients experience some degree of radiation-induced cystitis during or after EBRT. There is currently no efficient treatment for preventing radiation cystitis.

Dysuria

Urination

10.14661/1220

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Citations (5)