Ines Vujasinović

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccr3dcl

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Trzun, Marija, Paravić Radičević, Andrea ; Frka Borić, Kosjenka ; Jelić, Dubravko ; Vujasinović, Ines ; Mesić, Milan ; Eraković Haber, Vesna ; Brajša, Karmen

Marija Trzun Kosjenka Frka Borić Dubravko Jelić Ines Vujasinović Milan Mesić

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Synthesis and biological validation of novel pyrazole derivatives with anticancer activity guided by 3D-QSAR analysis

Bioorganic & Medicinal Chemistry (2012)

Ines Vujasinović Andrea Paravić-Radičević Kata Mlinarić‐Majerski Karmen Brajša Branimir Bertoša

Pyrazole

Moiety

Linker

10.1016/j.bmc.2012.01.032

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Citations (68)

Novel desosamine-modified 14- and 15-membered macrolides without antibacterial activity

Bioorganic & Medicinal Chemistry Letters (2012)

Ivana Palej Jakopović Mirjana Bukvić Krajačić Maja Matanović Škugor Vlado Štimac Dijana Pešić

10.1016/j.bmcl.2012.03.076

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Citations (12)

CCDC 941948: Experimental Crystal Structure Determination

The Cambridge Structural Database (2014)

Ivaylo Elenkov Boška Hrvačić Stribor Marković Milan Mesić Andreja Čempuh Klonkay

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc10m5f7

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N′-Substituted-2′-O,3′-N-carbonimidoyl Bridged Macrolides: Novel Anti-inflammatory Macrolides without Antimicrobial Activity

Journal of Medicinal Chemistry (2012)

Martina Bosnar Goran Kragol Sanja Koštrun Ines Vujasinović Berislav Bošnjak

Macrolide antibiotics, like erythromycin, clarithromycin, and azithromycin, possess anti-inflammatory properties. These properties are considered fundamental to the efficacy of these three macrolides in the treatment of chronic inflammatory diseases like diffuse panbronchiolitis and cystic fibrosis. However, long-term treatment with macrolide antibiotics presents a considerable risk for promotion of bacterial resistance. We have examined antibacterial and anti-inflammatory effects of a novel macrolide class: N'-substituted 2'-O,3'-N-carbonimidoyl bridged erythromycin-derived 14- and 15-membered macrolides. A small focused library was prepared, and compounds without antimicrobial activity, which inhibited IL-6 production, were selected. Data analysis led to a statistical model that could be used for the design of novel anti-inflammatory macrolides. The most promising compound from this library retained the anti-inflammatory activity observed with azithromycin in lipopolysaccharide-induced pulmonary neutrophilia in vivo. Importantly, this study strongly suggests that antimicrobial and anti-inflammatory activities of macrolides are independent and can be separated, which raises development plausibility of novel anti-inflammatory therapeutics.

Diffuse panbronchiolitis

Macrolide Antibiotics

Anti-inflammatory

Neutrophilia

Ketolide

10.1021/jm300356u

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Citations (30)

CCDC 273407: Experimental Crystal Structure Determination

The Cambridge Structural Database (2006)

Ines Vujasinović Jelena Veljković Kata Mlinarić‐Majerski Krešimir Molčanov B. Kojić-Prodić

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc95hlj

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CCDC 695071: Experimental Crystal Structure Determination

The Cambridge Structural Database (2009)

Ines Vujasinović Jelena Veljković Krešimir Molčanov B. Kojić-Prodić Kata Mlinarić‐Majerski

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccrb8nz

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CCDC 941949: Experimental Crystal Structure Determination

The Cambridge Structural Database (2014)

Ivaylo Elenkov Boška Hrvačić Stribor Marković Milan Mesić Andreja Čempuh Klonkay

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc10m5g8

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CCDC 688458: Experimental Crystal Structure Determination

The Cambridge Structural Database (2009)

Ines Vujasinović Jelena Veljković Krešimir Molčanov B. Kojić-Prodić Kata Mlinarić‐Majerski

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccr3dbk

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Ines Vujasinović

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