Kathiresan Karunakaran

University of Illinois Urbana-Champaign

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Dhevendran Maruthupandian

Madurai Medical College

Jayakumar Palanisamy

Government Mohan Kumaramangalam Medical College

Ioannis Chasiotis

University of Illinois Urbana-Champaign

Ashwin Rajendiran

Whiston Hospital

V. Arul

Madurai Medical College

Vivian Weiß

Vanderbilt University Medical Center

Mithun K. Dey

Rensselaer Polytechnic Institute

Elizabeth M. Jaffee

Sidney Kimmel Comprehensive Cancer Center

Kailey Caroland

Vanderbilt University Medical Center

Dayle K. Wang

Vanderbilt University Medical Center

Cooperative Institutions

Vanderbilt University Medical Center

Vanderbilt University

Madurai Medical College

Vanderbilt-Ingram Cancer Center

Government Rajaji Hospital

University of Illinois Urbana-Champaign

The University of Texas MD Anderson Cancer Center

Johns Hopkins University

Baylor College of Medicine

Nashville Oncology Associates

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Investigating the role of filler shape on the dynamic mechanical properties of glass‐filled epoxy composites

Polymer Composites (2022)

Kathiresan Karunakaran Sarthak S. Singh R. Kitey

Abstract The influence of filler shape and volume fraction on the dynamic mechanical characteristics of rigid glass filler epoxy composites is investigated. Two variants of glass fillers, spherical particle and slender (milled) fibers, are doped into the epoxy matrix till 10% volume fraction. The composites are room temperature cured and tested to measure their viscoelastic properties. The dynamic mechanical analyses performed in the temperature range of 20–180°C at 10 Hz suggest that the milled fiber composites display consistently higher storage and loss moduli, whereas the higher loss factor peaks were noted for the spherical particle composites. The C ‐factor, filler reinforcement efficiency of the composites and entanglement density, evaluated from the storage modulus values, indicate that the milled fibers composites are more effective in transferring the loads in both glassy and rubbery zones when compared against the spherical particle case. Also, the filler/matrix adhesion factor ( A factor) and the interphase adhesion factor, calculated from the loss factor curves reveal stronger filler/matrix interactions in the case of milled fiber epoxy composites. Interestingly, the filler geometry or volume fraction has only marginal influence on the glass transition temperature of the composites.

Volume fraction

Filler (materials)

Particle (ecology)

Loss factor

10.1002/pc.26737

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Citations (17)

Anamolous Course of Right Common Carotid Artery in a Case of Papillary Carcinoma Thyroid

Indian Journal of Surgery (2012)

Kathiresan Karunakaran D. MarudhuPandian R. Ganesan M. Gobinath

Cardiothoracic surgery

Course (navigation)

Vascular surgery

10.1007/s12262-012-0440-9

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Citations (1)

An Infection Burden on Thyroid (Tuberculosis of Thyroid): A Case Report

World Journal of Endocrine Surgery (2020)

Sankaran Muthukumar Hamid Syed Ahamed Kamil Jayakumar Palanisamy D. Asha Latha Kathiresan Karunakaran

Aim: To enlighten the treating physician about the importance of tuberculosis (TB) of thyroid.Background: Though the prevalence of TB is high in country like India, TB affecting the thyroid gland is a rare entity due to inherent antibacterial properties of the gland.A high degree of suspicion and thorough clinical knowledge is absolutely necessary for identification of this entity.Case description: A 55-year-old man presented with 8 weeks' history of swelling in midline of the neck and 2 weeks' history of pain over the swelling.Blood investigations including the thyroid profile were normal.Clinical examination was suggestive of infected thyroglossal cyst along with multinodular goiter.Ultrasound confirmed the clinical diagnosis and in addition revealed bilateral cervical lymph nodes.Ultrasound-guided fine-needle aspiration cytology (FNAC) of thyroid was inconclusive and FNAC of lymph nodes showed reactive changes.Patient underwent total thyroidectomy along with Sistrunk operation and biopsy of both right-and left-sided cervical lymph nodes.Incidentally, he was diagnosed with hypocortisolism as the patient went in for hypotension intraoperatively, which was managed appropriately.Histopathology revealed TB of the thyroid.Conclusion: Tuberculosis of thyroid, though a rare entity, should be borne in mind and included in the differential diagnosis, particularly in countries with high TB burden.Clinical significance: Identification of such conditions preoperatively can avoid unnecessary surgeries as these conditions can be managed by medical treatment.

10.5005/jp-journals-10002-1270

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Nonlinear time-dependent mechanical behavior of mammalian collagen fibrils

Acta Biomaterialia (2022)

Fan Yang Debashish Das Kathiresan Karunakaran Guy M. Genin Stavros Thomopoulos

Stress relaxation

10.1016/j.actbio.2022.03.005

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Citations (14)

Right non-recurrent laryngeal nerve associated with anomalous origin of right subclavian artery and bicarotid trunk

Sri Lanka Journal of Surgery/Sri Lanka journal of surgery (2015)

Dhevendran Maruthupandian Kathiresan Karunakaran V. Arul

The journal is the official publication of the College of Surgeons of Sri Lanka. Its mission is to reach the highest standard of scientific surgical practice by dissemination of high quality scientific information and to foster and promote the growth of scientific surgery in Sri Lanka and in the region. The Sri Lanka Journal of Surgery publishes peer-reviewed leading articles, review articles, scientific articles, perspectives and case reports in the field of surgery and broadly related surgical sciences The journal adheres to the publication ethics as portrayed by the Committee on Publication Ethics (COPE) and is a member of this organisation. It is listed as an ICMJE journal which follow its recommendations (ICMJE recommendations) on Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals.

Medical journal

Sri lanka

10.4038/sljs.v33i3.8183

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A rare case of intra-oral lipoma in a malignant disguise

Sri Lanka Journal of Surgery/Sri Lanka journal of surgery (2016)

Dhevendran Maruthupandian Kathiresan Karunakaran T. Rajkiran

10.4038/sljs.v33i4.8203

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A double-blind study of oral salbutamol supplement andRepeat sputum smear microscopy in enhancing diagnosis ofSmear-negative pulmonary tuberculosis in South India

R. Balasubramanian R. Rajeswari Ashish Naik M Duraipandian Kathiresan Karunakaran

Background: As routine culture facilities are not available in TB control programme in low income countries like India, there is an urgent need to improve the sensitivity of sputum microscopy, especially in diagnosis of smear negative pulmonary TB. Methodology: In a double blind placebo controlled study, the role of repeat sputum microscopy after antibiotics and oral salbutamol supplement in improving the diagnosis of smear negative TB suspects was investigated in an urban TB clinic. We undertook culture examinations for all study patients to find out proportions of TB cases in this series. Results: Of 206 enrolled, (101 salbutamol (S), 105 placebo (P) groups) 26 were positive by repeat sputum smear examination; similar in two groups (S 16, P 10, p = 0.25). In all, 40 (S 23, P 17) including 26 smear- positives, were culture -positive for M. tuberculosis. Conclusions: Two thirds of initially smear negative but culture positive TB patients were smear positive on repeat sputum examination. Thus, repeat sputum smear microscopy for TB suspects improved the diagnosis, nevertheless oral salbutamol therapy was not beneficial. In resource poor settings, repeat sputum smear microscopy after a trial of antibiotics, could significantly improve the diagnosis of smear-negative PTB patients.

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An integrated single-cell and spatial transcriptomic atlas of thyroid cancer progression identifies prognostic fibroblast subpopulations

bioRxiv (Cold Spring Harbor Laboratory) (2025)

Matthew A. Loberg George Xu Sheau‐Chiann Chen Hua‐Chang Chen Claudia C. Wahoski

Thyroid cancer progression from curable well-differentiated thyroid carcinoma to highly lethal anaplastic thyroid carcinoma is distinguished by tumor cell de-differentiation and recruitment of a robust stromal infiltrate. Combining an integrated thyroid cancer single-cell sequencing atlas with spatial transcriptomics and bulk RNA-sequencing, we define stromal cell subpopulations and tumor-stromal cross-talk occurring across the histologic and mutational spectrum of thyroid cancer. We identify distinct inflammatory and myofibroblastic cancer-associated fibroblast (iCAF and myCAF) populations and perivascular-like populations. The myCAF population is only found in malignant samples and is associated with tumor cell invasion, BRAF V600E mutation, lymph node metastasis, and disease progression. Tumor-adjacent myCAFs abut invasive tumor cells with a partial epithelial-to-mesenchymal phenotype. Tumor-distant iCAFs infiltrate inflammatory autoimmune thyroid lesions and anaplastic tumors. In summary, our study provides an integrated atlas of thyroid cancer fibroblast subtypes and spatial characterization at sites of tumor invasion and de-differentiation, defining the stromal reorganization central to disease progression.

10.1101/2025.01.08.631962

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Covering Ileal Loop without Ostomy: A New Approach to Bring Down the Enterostomy-Related Morbidity

International Journal of Recent Surgical and Medical Sciences (2021)

Kathiresan Karunakaran Jayakumar Palanisamy Dheivendiran Maruthupandian

Abstract Ileostomy is a commonly performed procedure for colon surgeries and the following emergency small or large bowel resection and anastomosis. We proposed a successful new technique of covering ileal loop without opening it, to decrease the stoma and reversal-related complications.

Enterostomy

Stoma (medicine)

Ileostomy

10.1055/s-0041-1731129

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Right non recurrent laryngeal nerve associated with anomalous origin of right subclavian artery and a bicarotid trunk

Bangladesh Journal of Medical Science (2016)

Dhevendran Maruthupandian Kathiresan Karunakaran V. Arul

Non recurrent laryngeal nerve is a rare anatomical variation with an incidence in literature of 0.3 % to 1.6 % on the right side. This variation places the nerve at risk of inadvertent injury during head and neck surgeries. Awareness about this abnormality and meticulous dissection of the nerve in every case is the only way to stay safeguarded. Here we present a case of right non recurrent laryngeal nerve in a 32 years old female patient who underwent near total thyroidectomy for nontoxic multi nodular goitre. During surgery, the right recurrent laryngeal nerve could not be identified in its normal location. Further dissection revealed a non recurrent laryngeal nerve arising from the vagal trunk. A CT angiogram was done post operatively and showed an anomalous origin of the right subclavian artery as the last branch of the aortic arch and a bi-carotid trunk. Every surgeon operating on the neck should be aware of and anticipate this variation of the recurrent laryngeal nerve especially when the nerve cannot be identified in the normal location.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.485-487

Superior laryngeal nerve

Abnormality

10.3329/bjms.v15i3.22989

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Citations (2)