Maryam Yadegari

Shiraz University of Medical Sciences

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Morteza Anvari

Shahid Sadoughi University of Medical Sciences and Health Services

Abbas Shahedi

Shiraz University of Medical Sciences

Hengameh Dortaj

Mashhad University of Medical Sciences

M Hosseini Sharifabad

Shahid Sadoughi University of Medical Sciences and Health Services

Mohammad Ebrahim Rezvani

Shahid Sadoughi University of Medical Sciences and Health Services

Majid Pourentezari

Shahid Sadoughi University of Medical Sciences and Health Services

Seyyed Majid Bagheri

Shahid Sadoughi University of Medical Sciences and Health Services

Fatemeh Zare Mehrjerdi

Shahid Sadoughi University of Medical Sciences and Health Services

Mozafar Khazaei

Kermanshah University of Medical Sciences

Mahmoud Orazizadeh

Ahvaz Jundishapur University of Medical Sciences

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Shahid Sadoughi University of Medical Sciences and Health Services

Hy-Line (United States)

RELX Group (Netherlands)

Tehran University of Medical Sciences

The University of Tokyo

Harvard University

Kermanshah University of Medical Sciences

Yazd University

Mashhad University of Medical Sciences

Shahid Beheshti University of Medical Sciences

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WOUND HEALING EFFECT OF FALCARIA VULGARIS' LEAVES ON ASPIRIN INDUCED GASTRIC ULCER IN RATS

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Kirmānshāh (2006)

Maryam Yadegari Mozafar Khazaei Roatam Ghorbani Mansour Rezae Babak Izadi

Introduction: According to the traditional use of falcaria vulgaris for gastric ulcer in the northwest of Iran, our pervious work showed protective effect of this vegetable on ethanol-induced gastric lesion. This study was designed to find out wound healing effect of hydroalcolic extract from falcaria vulgaris leaves on aspirin induced gastric ulcer in rats. Materials & Methods: 21 young male rats (NMRI strain), 190– 230g weight randomly divided into 3 groups; experimental, control positive and control negative (7 rats in each group). All animals had been exposed to starvation for 48 hours and then received oral ASA (200 mg/kg/day) in1ml carboxymethyl cellulose 1% solvent for 3 days. The experimental group, received 150mg/kg/day hydroalcoholic extract of falcaria vulgaris leaves (peculation methods), the control positive group received 200 mg/kg/day omeprazole and the control negative group received 1ml/kg/day distilled water for two weeks by gavages. Three hour after last treatment all animals were killed and stomachs were dissected. Number and length of ulcers determined using stereomicroscope and graticule and the ulcer index and curative ratio were calculated. Data were analysed using one-way ANOVA and Post-Hoc Tukey test. Results: Falcaria vulgaris extract (150mg/kg/day) significantly decreased gastric ulcer index compared to control positive and control negative groups (P<0.01). Curative ratio in experimental group was significantly higher than the control negative 89.26%, and control positive 87.79% groups . Conclusion: Hydroalcoholic extract of falcaria vulgaris showed significant effective wound healing in aspirin induced gastric ulcer in rats. Further studies in this field including human clinical trials are highly recommended.

Ulcer index

Negative control

10.22110/jkums.v10i3.524

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Gastrointestinal Endoscopy (2010)

Joel H. Rubenstein Nora Mattek Glenn M. Eisen Catherine F. Poh Anita Gąsiorowska

10.1016/s0016-5107(09)02772-2

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Comparison of the Success Rate of Trabeculectomy with OculusGen versus Trabeculectomy with Mitomycin C

Iranian Journal of Ophthalmology (2011)

Naveed Nilforushan Maryam Yadegari Parsa Hodjat

Purpose: To compare the effectiveness and safety of trabeculectomy with mitomycin C (MMC) versus trabeculectomy with OculusGen Methods: In this prospective study 14 eyes of 7 patients with a diagnosis of primary open angle glaucoma (POAG) that required trabeculectomy for both eyes were enrolled. For each patient we randomly performed trabeculectomy with MMC for one eye and trabeculectomy with subconjunctival OculusGen for fellow eye. Main outcome measures were: intraocular pressure (IOP), number of IOP reducing medications and surgical complications. Data analysis was performed using SPSS software version 15. Results: Mean age of the patients was 59±12.6 years. Mean duration of follow-up was 13±3.7 months for OculusGen group and 14.42±6.6 months for MMC group. Mean preoperative IOP was 19.14±3.8 mmHg with 3.14±0.37 number of medication and at last visit was 14.43±3.3 mmHg with 0.86±1.21 number of medication for OculusGen group. Mean preoperative IOP was 21.71±4.1 mmHg with 2.86±0.89 number of medication and at last visit was 12.29±3.5 mmHg with no medication for MMC group. The cumulative success at last visit was 100% in MMC group and 71.5% in OculusGen group (P=0.008%). No systemic or ocular complications related to MMC or OculusGen were seen.

Mitomycin C

Glaucoma medication

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Citations (8)

Antifertility effects of Falcaria vulgaris in female rat

Maryam Yadegari Mozafar Khazaei Yazdan Hamzavi A. Toloei

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Citations (4)

Effect of Berberine on the Status of Antioxidants in the Heart of Lead-Exposed Rats

Pharmaceutical Chemistry Journal (2023)

Marzieh Pourebrahimian Maryam Yadegari Azadeh Shahrokhi Raeini Mansour Esmaili Dehaj Fatemeh Zare Mehrjerdi

Malondialdehyde

10.1007/s11094-023-02837-w

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Altered expression patterns of complement factor H and miR‐146a genes in acute‐chronic phases in experimental autoimmune encephalomyelitis mouse

Journal of Cellular Physiology (2019)

Saba Gharibi Bahram Moghimi Dariush Haghmorad Mohammad Bagher Mahmoudi Ensieh Shahvazian

Abstract Considerable advances have been made in identification of the involvement of immune modulators in diseases. There is growing evidence on the role of complement pathway in pathogenesis and course of multiple sclerosis (MS). Moreover, it has been recognized that microRNAs (miRNAs) play an essential role in modulation and development of immune response in the central nervous system. We aimed to investigate the expression profile of complement factor H (CFH) and miR‐146a genes in experimental autoimmune encephalomyelitis (EAE) mouse model of MS to detect the possible roles of CFH and miR‐146a as biomarkers of MS disease stats. Expression of CFH and miR‐146a genes in liver and brain tissues of EAE mice was measured in acute and chronic phases of disease compared to matched controls using real‐time polymerase chain reaction. In the liver, increased expression of CFH gene was observed in the chronic phase compared to the acute phase. However, no significant difference was observed between acute and chronic phase mice with normal mice, while miR‐146a expression was significantly decreased in livers of EAE mice in chronic group compared to acute and control groups. The expression of CFH gene in brain had a significant decrease in acute and chronic phases compared to healthy mice. Taken together, these observations indicate probable implication of complement system and miR‐146a in course of immune‐related diseases and reveal more facts about the pathogenesis of MS. However, further work is needed to determine protein levels of CFH and other possible targets of miR‐146a in serum and cerebrospinal fluid of MS patients.

Pathogenesis

Complement factor B

Encephalomyelitis

10.1002/jcp.28583

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Combination effects of prednisolone and interleukin-4 protect bovine nasal cartilage explants from interleukin-1α induced degradation.

PubMed (2011)

Maryam Yadegari Mahmoud Orazizadeh Mahmoud Hashemitabar Ali Khodadadi

Current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. This study was undertaken to investigate the combination effects of IL-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(MMP-1) in IL-lα-treated bovine nasal cartilage (BNC) explants.BNC explants were cultured in DMEM with IL-lα (10 ng/ml), IL-4 (50 ng/ml) and prednisolone (1 or 1,000 nM) at the same time for 28 days. At days 3, 7, 14, 21 and 28, the media were collected and replaced with fresh media, and the removed media were stored at -20°C. The alterations of tissue characteristics were assessed by using histology techniques. Western-blot method was used to determine the effects of IL-4 and prednisolone combination on MMP-1 production. The cell viability was evaluated by using lactate dehydrogenase assay test.In the presence of IL-lα alone, most chondrocytes were transformed into fibroblast-like morphology with pyknotic nuclei at day 28. In addition, a clear band of MMP-1 and extracellular matrix (ECM) degradation were observed. In combination of IL-4 and prednisolone, chondrocytes preserved their ordinary normal features. MMP-1 band formation was completely inhibited and ECM absolutely showed normal characteristics. IL-4 and prednisolone did not show cytotoxicity effects on BNC explant culture.This combination can strongly preserve cartilage from degradation features and the data possibly suggest that the combination of IL-4 and prednisolone could be a candidate for alternative therapy in joint diseases.

Prednisolone

Viability assay

10.6091/ibj.1009.2012

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Evaluating effect of acrylamide and ascorbic acid on oxidative stress and apoptosis in ovarian tissue of wistar rat

Toxicology Reports (2022)

Amir Masoud Firouzabadi Maryam Imani Fatemeh Zakizadeh Nadia Ghaderi Fateme Zare

Acrylamide is one of the undesirable compounds created in food, which leads to oxidative stress. Under normal conditions of the body, there is a balance between the production and elimination of free radicals. Imbalance in this process causes oxidative stress. Ascorbic acid has antioxidant properties and can be used to prevent oxidative stress damage. In this study, we considered the effect of acrylamide as a substance that causes oxidative stress and ascorbic acid as an antioxidant. In this experiment, 28 rats were separated into 4 groups (n = 7). Mice were fed orally with acrylamide (10 mg/kg), ascorbic acid (200 mg/kg), both acrylamide and ascorbic acid, and water as AR, AA, AR&AA, and control groups, respectively. Blood and ovarian tissue samples were collected after the final feeding and anesthesia for hematological tests. Blood cells, anti-oxidation status and relative expression of BAX (Bcl-2 Associated X-protein), BCL-2 (B-cell lymphoma-2), Folliculogenesis Specific BHLH Transcription Factor (FIGLA), Follicle Stimulating Hormone Receptor (FSHR), and Klotho (KL) genes were assessed and compared between the study groups. Despite no change in the levels of other factors, white blood cells were significantly different between all groups. The total oxidant and antioxidant index had significant changes in the AR group compared to controls. Glutathione Peroxidase showed the least concentration in the AR group than others although this change was not significant. Gene expression of BAX, BCL-2, FIGLA, FSHR, and KL genes was not significant between the study groups (P > 0.05). The most ratio of BAX to BCL-2 belonged to the AR group compared to other groups. In conclusion, AR probably induces ovarian dysfunction by increasing the proportions of apoptosis-related genes, and the usage of antioxidants like AA can minimize its hazardous effects. However, more research is needed to uncover effective ways to limit AR exposure.

10.1016/j.toxrep.2022.07.015

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Citations (13)

Stereological Study on the Effects of Maternal Caffeine Consumption on Histomorphometric Changes of Testis and Prostate in Rat Offspring

Modern Medical Laboratory Journal (2020)

Mahboubeh Belali Kharaji Maryam Yadegari M Hosseini Sharifabad Morteza Anvari Abolghasem Abbasi Sarcheshmeh

Stereological Study on the Effects of Maternal Caffeine Consumption on Histomorphometric Changes of Testis and Prostate in Rat Offspring

Stereology

10.30699/mmlj17.3.1.46

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Citations (3)

SURVEY OF PROTECTIVE EFFECT OF HYDRO ALCOHOLIC EXTRACT OF FALCARIA VULGARIS ON ASPIRIN -INDUCED GASTRIC ULCER IN RAT