Gary McAuliffe

Auckland City Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

David R. Murdoch

University of Otago

Sally Roberts

Auckland City Hospital

Susan Taylor

Cornell University

Arlo Upton

Southern Community Laboratories (New Zealand)

Shivani Fox‐Lewis

Auckland City Hospital

Erasmus Smit

Auckland City Hospital

James E. Ussher

University of Otago

Susan C. Morpeth

Counties Manukau District Health Board

Juliet Elvy

Royal College of Pathologists of Australasia

David Murdoch

University of Otago

Cooperative Institutions

University of KwaZulu-Natal

128

Stellenbosch University

106

Africa Centres for Disease Control and Prevention

Kenya Medical Research Institute

Redeemer's University

University of Auckland

Institut Pasteur

University of Ghana

Inserm

University of Otago

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Faculty Opinions recommendation of Effect of household and community interventions on the burden of tuberculosis in southern Africa: the ZAMSTAR community-randomised trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)

David R. Murdoch Gary McAuliffe

10.3410/f.718059808.793482992

Cite

Citations (0)

Faculty Opinions recommendation of Integrated community case management of fever in children under five using rapid diagnostic tests and respiratory rate counting: a multi-country cluster randomized trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)

David R. Murdoch Gary McAuliffe

10.3410/f.717976239.793472116

Cite

Citations (0)

SARS-CoV-2 antibodies in the Southern Region of New Zealand, 2020

medRxiv (Cold Spring Harbor Laboratory) (2020)

Alyson Craigie Reuben McGregor Alana L. Whitcombe Lauren H. Carlton David Harte

Abstract Background During New Zealand’s first outbreak in early 2020 the Southern Region had the highest per capita SARS-CoV-2 infection rate. PCR testing was initially limited by a narrow case definition and limited laboratory capacity, so cases may have been missed. Objectives To evaluate the Abbott ® SARS-CoV-2 IgG nucleocapsid assay, alongside spike-based assays, and to determine the frequency of antibodies among PCR-confirmed and probable cases, contacts, and higher risk individuals in the Southern Region of NZ. Study design Pre-pandemic sera (n=300) were used to establish assay specificity and sera from PCR-confirmed SARS-CoV-2 patients (n=78) to establish sensitivity. For prevalence analysis, all samples (n=1214) were tested on the Abbott assay, and all PCR-confirmed cases (n=78), probable cases (n=9), and higher risk individuals with grey-zone (n=14) or positive results (n=11) were tested on four additional SARS-CoV-2 serological assays. Results The median time from infection onset to serum collection for PCR-confirmed cases was 14 weeks (range 11-17 weeks). The Abbott assay demonstrated a specificity of 99.7% (95% CI, 98.2%-99.99%) and a sensitivity of 76.9% (95% CI, 66.0%-85.7%). Spike-based assays demonstrated superior sensitivity ranging 89.7-94.9%. Nine previously undiagnosed sero-positive individuals were identified, and all had epidemiological risk factors. Conclusions Spike-based assays demonstrated higher sensitivity than the Abbott IgG assay, likely due to temporal differences in antibody persistence. No unexpected SARS-CoV-2 infections were found in the Southern region of NZ, supporting the elimination status of the country at the time this study was conducted.

Seroprevalence

10.1101/2020.10.20.20215616

Cite

Citations (3)

An understanding of discordant SARS-CoV-2 test results: an examination of the data from a central Auckland laboratory

New Zealand medical journal (2020)

Shivani Fox‐Lewis Sharmini Muttaiyah Fahimeh Rahnama Gary McAuliffe Sally Roberts

AIM: The diagnostic sensitivity of the SARS-CoV-2 real time reverse transcription polymerase chain reaction (RT-PCR) test has not been determined This has led to a degree of uncertainty in the interpretation of results, particularly in patients tested repeatedly The aim of this study was to explore the characteristics of patients who initially tested negative, and subsequently tested positive for SARS-CoV-2 METHODS: This retrospective observational study utilised data from the LabPlus Virology laboratory, Auckland City Hospital, to identify cases (hospital and community) with initial negative and subsequent positive SARS-CoV-2 RT-PCR results Their clinical and laboratory characteristics were summarised RESULTS: From 1 February to 13 April a total of 20,089 samples were received for SARS-CoV-2 testing Of 2,011 samples from patients with multiple tests, 25 samples were positive Nine samples were from patients who initially tested negative then tested positive Reasons for the initial negative test results, which were all from upper respiratory tract samples, included pre-symptomatic presentation or late presentation All patients had significant risk factors and ongoing or evolving symptoms, which warranted repeat testing CONCLUSION: Few patients had discordant test results for SARS-CoV-2 RT-PCR For patients who have a significant risk factor and a negative test result, repeat testing should be performed

Pcr test

False Negative Reactions

Source

Cite

Citations (7)

The association between antimicrobial resistance mutations and treatment outcomes for Mycoplasma genitalium infections from 2018 to 2022: a cross-sectional study from Auckland, New Zealand

Sexual Health (2024)

Shivani Fox‐Lewis Rose Forster Indira Basu Matthew Blakiston Gary McAuliffe

Background New Zealand has among the highest rates of antimicrobial resistance in Mycoplasma genitalium in the world. The aim of this study was to correlate treatment outcomes with 23S rRNA and parC mutations associated with macrolide and fluroquinolone resistance, respectively, in a cohort of sexual health clinic patients. Methods Laboratory and clinical data were collected for patients with M. genitalium infections attending Auckland Sexual Health Service between 1 January 2018 and 31 December 2022, who had a test-of-cure performed within 21–90 days of a treatment episode. Treatment outcomes were correlated with the presence or absence of resistance mutations and treatment regimen utilised. Results A total of 95 infections from 93 patients met the study inclusion criteria. Eighty of 93 (86%) infections with available data were macrolide resistant, with 20 of 74 (27%) having both macrolide resistance and parC mutations. Sixteen of 20 (80%) of parC mutations were G248T (S83I), three of 20 (15%) G259T (D87Y) and one of 20 (5%) A247C (S83R). All macrolide-susceptible infections treated with doxycycline and azithromycin were cured (12/12), as were all macrolide-resistant infections without parC mutations treated with doxycycline and moxifloxacin (37/37). Cure rates for macrolide-resistant infections with parC mutations were lower, with variable and often multiple treatment courses; eight of 16 (50%) were cured using one course of sequential doxycycline and moxifloxacin, seven of nine (78%) with one course of minocycline, zero of two (0%) with pristinamycin and one of one (100%) with doxycycline and sitafloxacin. Conclusions Our findings highlight the differing treatment outcomes for infections with and without parC mutations, offering opportunities to refine management of M. genitalium infections.

Mycoplasma genitalium

10.1071/sh24166

Cite

Citations (0)

Politicians: please work together to minimise the spread of COVID-19

New Zealand medical journal (2020)

David R. Murdoch Michael Addidle Hanna Sofia Andersson Brendan Arnold Michelle Balm

2019-20 coronavirus outbreak

Betacoronavirus

Coronavirus Infections

Pandemic

Source

Cite

Citations (10)

Faculty of 1000 evaluation for Increased use of community medicine distributors and rational use of drugs in children less than five years of age in Uganda caused by integrated community case management of fever.

F1000 - Post-publication peer review of the biomedical literature (2013)

David R. Murdoch Gary McAuliffe

Read the full review for this Faculty Opinions recommended article: Increased use of community medicine distributors and rational use of drugs in children less than five years of age in Uganda caused by integrated community case management of fever.

Community Management

10.3410/f.717976238.793472115

Cite

Citations (0)

Faculty Opinions recommendation of Randomized controlled trial to reduce bacterial colonization of surgical drains after breast and axillary operations.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2013)

David R. Murdoch Gary McAuliffe

Surgical procedures

10.3410/f.717995467.793475238

Cite

Citations (0)

Faculty Opinions recommendation of Performance of the GeneXpert CT/NG assay compared to that of the Aptima AC2 assay for detection of rectal Chlamydia trachomatis and Neisseria gonorrhoeae by use of residual Aptima Samples.