J.I.M. Egger

Vincent Van Gogh Voor Geestelijke Gezondheidszorg

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W.M.A. Verhoeven

Vincent Van Gogh Voor Geestelijke Gezondheidszorg

W.M.A. Verhoeven

Erasmus University Rotterdam

Tjitske Kleefstra

Radboud University Medical Center

S. Tuinier

Vincent Van Gogh Voor Geestelijke Gezondheidszorg

Roy P. C. Kessels

Radboud University Nijmegen

Ellen Wingbermühle

Vincent Van Gogh Voor Geestelijke Gezondheidszorg

Paul T. van der Heijden

Reinier van Arkel

Nicole de Leeuw

Radboud University Medical Center

Jan Derksen

Radboud University Nijmegen

Serge J. W. Walvoort

GGZ Oost Brabant

Cooperative Institutions

Radboud University Nijmegen

191

Radboud University Medical Center

107

Vincent Van Gogh Voor Geestelijke Gezondheidszorg

University Medical Center

Istituti di Ricovero e Cura a Carattere Scientifico

Erasmus University Rotterdam

Erasmus MC

Maastricht University

University of Amsterdam

Memorial Sloan Kettering Cancer Center

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Downsyndroom: Monoaminen, aminozuren en neopterine

Tijdschrift voor psychiatrie (2007)

A.W. Coppus Durk Fekkes S. Tuinier W.M.A. Verhoeven J.I.M. Egger

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The relationship between theory of mind and relational frame theory: Convergence of perspective-taking measures.

A.L. Hendriks Yvonne Barnes‐Holmes Ciara McEnteggart H.R.A. De Mey Cilia Witteman

Objective: Perspective-taking difficulties have been demonstrated in autism and schizophrenia spectrum disorders, among other clinical presentations, and are traditionally examined from a Theory of Mind (ToM) point of view. Relational Frame Theory (RFT) offers a behavioural and contextual interpretation of perspective-taking, proposing that this ability can be studied in more detail by examining specific perspective-taking relations. To implement relational perspective-taking measures in clinical practice, it is important to gain more knowledge about how these relate to traditional measures of perspective-taking. Method: The current study is focused on the relation between the Barnes-Holmes relational perspective-taking protocol and both the Faux-pas and the Strange Stories tests, in a sample of healthy controls and individuals with an anxiety disorder or psychotic disorder. The work expands upon earlier research in this field. Results: Our results showed that, across the whole sample, the Barnes-Holmes protocol was positively correlated with both the Faux-pas and the Strange Stories tests. Furthermore, the Barnes-Holmes protocol was found to predict ToM performance. Correlations between the Strange Stories test and the Barnes-Holmes protocol were non-significant when we corrected for intelligence. Conclusions: The evidence suggests that relational perspective-taking is strongly related to ToM performances. Results are compared to other RFT studies and implications for clinical practice are discussed.

Relational frame theory

Relational theory

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The Relation between Behavioral, Emotional and Cognitive Apathy and Everyday Executive Dysfunction in Alcoholic Korsakoff’s Syndrome

DOAJ (DOAJ: Directory of Open Access Journals) (2021)

Roy P. C. Kessels Wiltine Moerman van den Brink Yvonne C. M. Rensen Loes van Aken Serge J. W. Walvoort

ABSTRACT Background: Apathy is an important neuropsychiatric symptom in alcohol-related cognitive impairment in general, and Korsakoff’s syndrome in specific. However, research in patients with Korsakoff’s syndrome on the multifaceted nature of apathy is lacking. Objectives: Aim of the current study was to examine behavioral, cognitive and emotional apathy in alcoholic Korsakoff patients, also investigating the association with overall cognitive and executive dysfunction. Methods: We studied 43 patients with Korsakoff’s syndrome (mean age 60.9, SD=6.5, range 38-70) using the Apathy Evaluation Scale - Informant Version (AES-I) and also administered the Montreal Cognitive Assessment and the Behavior Rating Inventory of Executive Function - Adult Version (BRIEF-A) as a measure of daily executive problems. Results: In our sample, 76% of the Korsakoff patients were classified as being apathetic. AES-I scores correlated with overall cognitive function and were related to observer-rated daily executive problems. Discussion: Apathy is highly prevalent in Korsakoff patients and related to overall cognitive dysfunction and everyday executive problems. Our results stress the need to further examine underlying mechanisms of apathy in Korsakoff patients and the need for interventions aimed at reducing apathy.

Apathy

Executive dysfunction

10.15761/0101-60830000000301

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Het psychopathieprofiel Een verfijnde kijk op psychopathie met de PCL-R en de MMPI-2

GZ - Psychologie (2010)

P. van den Bos B.A.W. Mol Youri P.M.J. Derks K. Zwijnenburg J.I.M. Egger

10.1007/s41480-010-0008-x

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The RC scales predict psychotherapy outcomes: The predictive validity of the MMPI-2's restructured clinical scales for psychotherapeutic outcomes

Personality and Mental Health (2012)

Wubbo Scholte Bea Tiemens Roel Verheul Anke M.M.A. Meerman J.I.M. Egger

ABSTRACT This study investigated the capacity of the Minnesota Multiphasic Personality Inventory's (MMPI‐2) restructured clinical (RC) scales to predict treatment outcomes of inpatient psychotherapy concerning long‐term changes in the level of psychopathology for patients with personality disorders. The predictive capacity of the RC scales is compared with that of the clinical scales. The MMPI‐2 was administered at baseline. We followed up 179 patients for 36 months. The Brief Symptom Inventory measured the symptom changes between baseline and the end of the treatment as well as between baseline and 36 months. The RC2 (Low Positive Emotions) scale and RC8 (Aberrant Experiences) scale predicted lower levels of symptomatic improvements at 36 months. These scales did not have a significantly better performance than the original clinical scales. The RC2 and the 2(Depression) scale of the clinical scales predicted less improvement at 36 months. These findings emphasize that the RC scales should not be used alone or as a replacement for the clinical scales. Copyright © 2012 John Wiley & Sons, Ltd.

Depression

10.1002/pmh.1190

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Citations (5)

Top-down or bottom-up: Contrasting perspectives on psychiatric diagnoses

Biologics (2008)

W.M.A. Verhoeven J.I.M. Egger W. Boudewijn Gunning Michael W. Bevers Boudewijn J. H. B. de Pont

Clinical psychiatry is confronted with the expanding knowledge of medical genetics. Most of the research into the genetic underpinnings of major mental disorders as described in the categorical taxonomies, however, did reveal linkage with a variety of chromosomes. This heterogeneity of results is most probably due to the assumption that the nosological categories as used in these studies are disease entities with clear boundaries. If the reverse way of looking, the so-called bottom-up approach, is applied, it becomes clear that genetic abnormalities are in most cases not associated with a single psychiatric disorder but with a certain probability to develop a variety of aspecific psychiatric symptoms. The adequacy of the categorical taxonomy, the so-called top-down approach, seems to be inversely related to the amount of empirical etiological data. This is illustrated by four rather prevalent genetic syndromes, fragile X syndrome, Prader-Willi syndrome, 22q11 deletion syndrome, and Noonan syndrome, as well as by some cases with rare chromosomal abnormalities. From these examples, it becomes clear that psychotic symptoms as well as mood, anxiety, and autistic features can be found in a great variety of different genetic syndromes. A psychiatric phenotype exists, but comprises, apart from the chance to present several psychiatric symptoms, all elements from developmental, neurocognitive, and physical characteristics.

Neurocognitive

Etiology

Categorical variable

10.2147/btt.s3053

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Citations (11)

Neuropsychological and Behavioral Aspects of Noonan Syndrome

Hormone Research in Paediatrics (2009)

E. Wingbermuehle J.I.M. Egger Ineke van der Burgt W.M.A. Verhoeven

The current paper introduces concise neuropsychological assessment as an essential tool for studying the contribution of cognition and behavior in the expression of genetic syndromes, like Noonan syndrome (NS). Cognitive and behavioral findings in NS show intelligence scores across a wide range, with a mildly lowered average level. Language and motor development are often delayed, but no longer dysfunctional in adulthood. Continuing mild problems in selective and sustained attention are noted, as well as suboptimal organization skills and compromised abilities to structure complex information. These problems seem to culminate in learning difficulties, requiring attention for special needs in education. It seems that a complex of psychosocial immaturity, alexithymia and amenable traits is typical of NS patients. Consequently, psychopathology or psychological problems in leading a self-serving life may often remain underreported. This is why the authors advocate the integration of the domain of social cognition and personality in NS assessment.

Noonan Syndrome

Dysfunctional family

10.1159/000243774

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Citations (35)

Alexithymia, emotion perception, and social assertiveness in adult women with Noonan and Turner syndromes

American Journal of Medical Genetics Part A (2015)

Renée L. Roelofs Ellen Wingbermühle Kim Freriks C.M. Verhaak Roy P. C. Kessels

Noonan syndrome (NS) and Turner syndrome (TS) are associated with cognitive problems and difficulties in affective information processing. While both phenotypes include short stature, facial dysmorphisms, and a webbed neck, genetic etiology and neuropsychological phenotype differ significantly. The present study examines putative differences in affective information processing and social assertiveness between adult women with NS and TS. Twenty‐six women with NS, 40 women with TS, and 40 female controls were matched on age and intelligence, and subsequently compared on (1) alexithymia, measured by the Bermond‐Vorst Alexithymia Questionnaire, (2) emotion perception, evaluated by the Emotion Recognition Task, and (3) social assertiveness and social discomfort, assessed by the Scale for Interpersonal Behavior. Women with TS showed higher levels of alexithymia than women with NS and controls ( P ‐values < 0.001), whereas women with NS had more trouble recognizing angry facial expressions in comparison with controls ( P = 0.01). No significant group differences were found for the frequency of social assertiveness and the level of social discomfort. Women with NS and TS demonstrated different patterns of impairment in affective information processing, in terms of alexithymia and emotion perception. The present findings suggest neuropsychological phenotyping to be helpful for the diagnosis of specific cognitive‐affective deficits in genetic syndromes, for the enhancement of genetic counseling, and for the development of personalized treatment plans. © 2015 Wiley Periodicals, Inc.

Noonan Syndrome

Assertiveness

Emotion Perception

Social information processing

10.1002/ajmg.a.37006

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Citations (13)

Assessing Psychological Inflexibility Pertaining to Self in Patients With Posttraumatic Stress Disorder Using an Indirect Measure of (Nonassociative) Propositions

Behavior Therapy (2022)

Petrus G.J. Janssen Ciara McEnteggart Dermot Barnes‐Holmes Elisa van Ee J.I.M. Egger

Relational frame theory (RFT) is a modern behavioral account of human language and cognition, which focuses on relations or propositions, rather than associations, as core explanatory constructs. In an attempt to measure such propositions, RFT researchers have developed the implicit relational assessment procedure (IRAP). It has been argued that the size of an IRAP effect may provide a metric for psychological inflexibility. The current study aimed to determine whether psychological inflexibility, as measured by the self-focused Natural Language-IRAP (NL-IRAP), would be higher in a clinical sample of individuals with a diagnosis of PTSD (N = 29) when compared to a nonclinical sample. Subsequently, the study investigated whether the self-focused NL-IRAP could be used to predict the presence of a clinical diagnosis, using a ROC analysis. As predicted, higher levels of psychological inflexibility were observed for the clinical group. The self-focused NL-IRAP also correctly classified the presence of PTSD (AUC = 76%) with a sensitivity level of 79.3% and a specificity level of 59.2%. Overall, the use of the IRAP as a nonassociative clinical measure appears promising.

Relational frame theory

10.1016/j.beth.2022.05.002

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Citations (2)

Anxiety Change Expectancy Scale--Dutch Language Version

PsycTESTS Dataset (2017)

Wendy J. C. van der Sterren-Kusters Paul T. van der Heijden J.I.M. Egger

10.1037/t66474-000

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Citations (1)