A. Dubouloz

University Hospital of Geneva

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M. Rouzaud

University Hospital of Geneva

Raymond Miralbell

University Hospital of Geneva

Thomas Zilli

Institute of Oncology Research

G. Dipasquale

Ospedale Santa Maria alle Scotte

Maud Jaccard

University of Lausanne

Philippe Nouet

University Hospital of Geneva

S. Jorcano

Hospital Quirón Teknon

L. Escudé

University Hospital of Geneva

Nikolaos Koutsouvelis

University Hospital of Geneva

Juan María Pérez-Moreno

Hospital Universitario Quirónsalud Madrid

Cooperative Institutions

University Hospital of Geneva

University of Geneva

Hôpital Beau-Séjour

Geneva College

Radiation Oncology Associates

Hospital Quirón Teknon

Siemens Healthcare (United States)

Sheba Medical Center

Inserm

Amsterdam University Medical Centers

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3 Single shot stereotactic body radiotherapy for localized prostate cancer: Case report

Physica Medica (2018)

Nikolaos Koutsouvelis G. Dipasquale A. Dubouloz Maud Jaccard Raymond Miralbell

Truebeam

Cyberknife

10.1016/j.ejmp.2018.09.016

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Citations (1)

Phantom based KV-CBCT dose plan calculations for re-planning decision: Comparison with CT-based dose plans

Physica Medica (2013)

A. Dubouloz Philippe Nouet G. Dipasquale M. Rouzaud

Hounsfield scale

Cone-Beam CT

Thorax (insect anatomy)

10.1016/j.ejmp.2013.08.011

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Citations (1)

Urethra-Sparing Stereotactic Body Radiation Therapy for Prostate Cancer: Quality Assurance of a Randomized Phase 2 Trial

International Journal of Radiation Oncology*Biology*Physics (2020)

Maud Jaccard Thomas Zilli A. Dubouloz Lluís Escudé S. Jorcano

10.1016/j.ijrobp.2020.06.002

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Citations (22)

EP-1365: Dosimetric predictors for rectal toxicity with two hypofractionated schedules for prostate cancer

Radiotherapy and Oncology (2016)

Thomas Zilli Melpomeni Kountouri M. Rouzaud A. Dubouloz D. Linero

________________________________________________________________________________patient.Acute and late toxicity were analyzed, according to CTCAE toxicity scale (v.4.0). Results:The median follow-up was 14.5 months.Most of patients received 30 Gy, in 3 fractions, on alternative days: all the patients completed the prescribed SBRT treatment.Fifteen patients (71%) received androgen deprivation therapy concomitant to SBRT.SBRT was well tolerated: only 1 patient experienced G2 acute rectal toxicity but we didn't observe any severe acute or late toxicity ( ≥G3).Despite the short follow up, local control was 100%, distant control was 79% (6/21).All these recurrences were nodal and all out of SBRT field: in 2 of these 6 patients a new SBRT course was delivered (30 Gy in 3 fractions) while in the other hormonal therapy was proposed.At the moment of analysis, all patients were alive. Conclusion:Our experience shows that SBRT for isolated nodal relapse from prostate cancer is a safe treatment, offering a low toxicity profile and an excellent tumor local control.More data and a longer follow up are needed. EP-1364Role of choline PET/CT in Cyberknife treatment planning for recurrent prostate cancer following EBRT

10.1016/s0167-8140(16)32615-9

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12 Early clinical experience of lung stereotactic body radiotherapy using deep inspiration breath-hold with real-time tumour tracking

Physica Medica (2019)

A. Dubouloz Maud Jaccard Allen F. Champion Jérôme Plojoux P. Gasche

Tracking (education)

10.1016/j.ejmp.2019.09.093

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Citations (0)

EP-1531: Stereotactic radiosurgery dose quality assurance: a commercial plastic scintillation versus a diamond detector

Radiotherapy and Oncology (2014)

G. Dipasquale C. Sedmak Philippe Nouet Sam Beddar A. Dubouloz

10.1016/s0167-8140(15)31649-2

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Citations (1)

TH-D-210A-03: Thick Monolithic Pixelated Scintillator Array for Megavoltage Imaging

Medical Physics (2009)

Jonathan S. Maltz Jens Hartmann A. Dubouloz A Paidi B Gangadharan

We describe the fabrication and evaluation of a thick pixelated scintillator for megavoltage (MV) imaging composed of a ceramic containing over 99.9% gadolium oxysulfide. This sintered material offers a 59% increase in density over the Lanex Fast B (LFB) phosphor screens most commonly employed in MV imaging. The sintered pixelated array (SPA) is fabricated from a single slab of ceramic. This obviates the need to assemble over a million separate crystals in order to cover a 40.96cm × 40.96cm detector area. As a consequence, the design is amenable to fabrication using methods of mass production. Method and Materials: A 1.8mm-thick 274 × 250 pixel SPA with 0.4mm pixel pitch is attached to the light-sensitive surface of an amorphous silicon flat panel detector (Perkin Elmer XRD1640AN). Image quality is characterized using 1MU exposures of the 6MV beam of a Siemens Primus Linac. A QC-3V phantom is employed to calculate the modulation transfer function (MTF) and contrast-to-noise ratio (CNR). The detective quantum efficiency (DQE) is computed. A LFB screen is then evaluated under identical conditions for comparative purposes. Cone beam CT (CBCT) imaging is performed with four arrays tiled side-by-side on the detector surface. Results: The half-maximum value of MTF occurs at 0.32 and 0.34lp/mm for the SPA and LFB, respectively. The DQE(0.1lp/mm) of SPA is 5.8%, versus 1.0% for LFB. The SPA offers a 235% improvement in CNR over LFB. Previously undetectable low-contrast phantom inserts are clearly visible in SPA MV-CBCT images. Conclusions: The SPA appears to offer a practical and cost-effective means of attaining major improvements in MV image quality. The measured MTF and DQE values underestimate the achievable performance, since the SPA and detector photodiode arrays were imperfectly aligned during these evaluations. A DQE(0) value closer to the maximum attainable 7.8% is expected. Conflict of Interest: Sponsored by Siemens.

Detective quantum efficiency

Optical transfer function

Dot pitch

Flat panel detector

10.1118/1.3182705

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Citations (3)

Quality Assurance of Small Animal Irradiation: Validation of a 3D-Printed Phantom for “Quasi In-Vivo” Dosimetry

International Journal of Radiation Oncology*Biology*Physics (2018)

Nikolaos Koutsouvelis Benjamin B. Tournier Valentina Garibotto Maud Jaccard A. Dubouloz

Bolus (digestion)

10.1016/j.ijrobp.2018.07.1361