This study aimed to investigate the effects of systemic omeprazole treatment on the osseointegration of titanium implants.After surgical insertion of titanium implants into the metaphyseal part of rats' both right and left tibial bones, the animals were randomly divided into three equal groups: control (n = 8), omeprazole dosage-1 (n = 8) (OME-1), and omeprazole dosage-2 (n = 8) (OME-2) and totally 48 implants were surgically integrated. The rats in the control group received no treatment during the four-week postoperative experimental period. In the OME-1 and OME-2 groups, the rats received omeprazole in doses of 5 and 10 mg/kg, respectively, every 3 days for 4 weeks. After the experimental period, the rats were euthanized. One rat died in each group and the study was completed with seven rats in each group. Blood serum was collected for biochemical analysis, and the implants and surrounding bone tissue were used for biomechanical reverse-torque analysis. In the biomechanical analysis, implants that were not properly placed and were not osseointegrated were excluded from the evaluation.One-way analysis of variance and Tukey's honestly significant difference test and Student's t test were used for statistical analysis. The reverse-torque test (control (n = 9), OME-1 (N = 7), and OME-2 (n = 7)) analysis of biochemical parameters (alkaline phosphatase, calcium, phosphorus, aspartate aminotransferase, alanine amino transferase, urea, and creatinine) revealed no significant differences between the groups (control (n = 7), OME-1 (N = 7), and OME-2 (n = 7)) (P > 0.05).Omeprazole had no biomechanical or biochemical effects on the osseointegration process of titanium implants.
To evaluate the fracture strength of polyetheretherketone (PEEK) single crowns veneered with different materials produced by computer-aided design (CAD)-computer-aided manufacture (CAM) after aging.60 stainless-steel master dies were prepared with a 1 mm-wide deep chamfer. Sixty PEEK frameworks were produced with a CAD-CAM system for the right maxillary first molar tooth on the dies. PEEK frameworks were divided into six groups (n= 10) according to veneering materials (five CAD-CAM materials and a resin composite). Group ZR: monolithic zirconia (Upcera ST-Color); Group EC: lithium disilicate glass-ceramic (IPS e.max CAD); Group LU: resin nano-ceramic (Lava Ultimate); Group VM: feldspathic ceramic (Vitablocs Mark II); Group VS: zirconia-reinforced lithium silicate glass-ceramic (VITA Suprinity); and Group CR: indirect resin composite (Gradia). All samples were subjected to a fracture strength test in a universal test device after thermo-mechanical aging and then the results were analyzed statistically using one-way ANOVA and Tukey's post hoc test. In addition, post-fracture analyses of all samples were performed with a stereomicroscope.The differences in fracture strength values of different veneer materials in single crowns with a PEEK framework were statistically significant (P< 0.05). Fracture strength was highest in Group ZR (1665 N), followed by Groups LU (1440 N), EC (1249 N), CR (918 N), VS (754 N), and VM (655 N).PEEK frameworks may have the potential to be used with many veneer materials of different content and properties in fixed partial prostheses.
Aim:We evaluated the polymerization properties of mostly used three hard chairside reline materials and a self-cure acrylic resin.By polymerizing these materials in a device simulating an intraoral area, the setting time of polymerization, polymerization temperature and change in enthalpy were established. Material and Method:The denture-lining materials investigated were three hard chairside reline materials (Ufi Gel Hard, Elite Hard Relining, and GC Reline) and an autopolymerizing acrylic resin (SC Self-Cure Acrylic) at body temperature.The study was performed at Firat University, Faculty of Science.A sapphire differential scanning calorimetry device (Sapphire-DSC) was used to analyze the reline materials.Results: Statistically significant differences were observed among materials with respect to a change in enthalpy (p<0.001) and temperature (p<0.05) during polymerization.However, no significant difference was established for the setting time (p>0.05). Conclusion:The Elite Hard Reline material showed the best results in all categories.Our results indicated that the enthalpy and temperature changes in the GC Reline sample was extremely high compared to the other hard chairside materials and self-cure acrylic sample.
Aims and Background Capecitabine is a potent and safe agent that can be used after anthracycline and taxane treatment in patients with metastatic breast cancer (MBC). The purpose of this study was to investigate the efficacy and safety of capecitabine monotherapy as a first-line treatment in human epidermal receptor 2 (HER2)-negative patients with MBC. Methods and Study design In this single-center trial, a total of 109 HER2-negative patients with MBC who received capecitabine monotherapy as first-line treatment between 2003 and 2014 were retrospectively analyzed. Kaplan-Meier survival analysis was carried out for progression-free survival (PFS) and for overall survival (OS). Two-sided p values of <0.05 were considered statistically significant. Results Median PFS was 7.0 ± 0.67 (confidence interval (CI) 5.6-8.3) months and median OS was 30 ± 4.1 (CI 21.8-38.1) months. First-line capecitabine treatment for HER2-negative MBC was more effective in the estrogen receptor (ER)-positive patient population compared to the ER-negative group (median PFS 9 vs 4 months (p = 0.002), median OS 33 vs 21 months (p = 0.01)). Indeed, the overall response rate in the ER-negative group was 16%, while this was calculated as 38% for ER-positive cases. While most of our patient population was treated with a higher dose (1250 mg/m 2 ), the observed grade 3-4 toxicities were lower compared to some previously reported phase II and phase III capecitabine studies. Conclusions Capecitabine monotherapy is an effective and safe regimen for ER-positive, HER2-negative patients with MBC. Its low toxicity profile compared to other intravenous cytotoxic agents and the ease of its oral administration make this agent a preferable option for both physicians and patients.
Aim: In this in vitro study, the effect of two adhesive systems applied to surfaces of different polyether-ether-ketone (PEEK) composites on the shear bond strength (SBS) of a composite resin was compared.
Methodology: Eighty PEEK specimens were divided into four groups (n=20): Unfilled PEEK (UF), carbon-fiber-reinforced PEEK (CFR), glass-fiber-reinforced PEEK (GFR), and ceramic-reinforced PEEK (CR). Each group was further divided into two subgroups (n=10): Visio.link (VL) and Single Bond Universal (SB). The specimens with 8-mm diameter and 5-mm thickness were prepared. SBS was examined using a universal testing machine. Results were statistically analyzed by multivariate analysis of variance and Tukey’s post-hoc test. Failure modes were analyzed using a stereomicroscope at 20× magnification. Surface properties were examined by scanning electron microscopy. The surface properties of the specimens were examined by scanning electron microscopy (SEM).
Results: Effect of different PEEK and adhesive systems on SBS was found to be statistically significant (p<0.05). SBS values for CFR-VL and UF-VL groups were statistically more significant than those for CFR-SB and UF-SB groups (p=0.001). SBS values for the GFR-VL group were statistically more significant than that for the UF-VL group (p=0.001). SBS values for the CF-SB group were statistically more significant than those for CFR-SB and CFR-SB groups (p=0.001). Failure modes were examined using a stereomicroscope at 20× magnification, and adhesive and mixed failure modes were observed.
Conclusion: PEEK composites with different contents and properties can be used in fixed prosthetic restorations. However, additional experimental and clinical studies are required to investigate different PEEK frameworks and composite veneers.
How to cite this article: Demirci F, Tekin S. Comparison of two adhesive systems of various polyetheretherketone (PEEK) composites on the shear bond strength. Int Dent Res 2021;11(2):54-61. https://doi.org/10.5577/intdentres.2021.vol11.no2.1
Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.
ÖZGiriş ve Amaç: Bu çalışmasının amacı, maksillaya uygulanan implant destekli zirkonya-seramik kuronlarda implantların yerleştirme açısının stres dağılımları üzerindeki etkilerinin karşılaştırılmasıdır
Purpose:The synthesis of ten new naphthyridine-hydrazone derivatives and subsequent evaluation of their antimicrobial activities were aimed in this present work.Material and Methods: The structure of the compounds was elucidated by 1H-NMR and MS spectral data.Additionally the compounds were evaluated for their antimicrobial activity against a panel of pathogenic bacteria and fungus strains.The panel of microorganisms Escherichia coli, Salmonella typhimurium, Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Listeria monocytogenes and Candida albicans were tested in vitro using a microdilution method.Results: All compounds showed significant antimicrobial activity against S. typhimurium and C. albicans when compared with reference agents.Conclusion: All synthesized compounds had significant antifungal activity when compared with ketoconazole.
The aim of this study was to compare the wear and fracture resistance of single crowns produced from newly developed 3D printer resins used to produce permanent crowns and currently used composite CAD/CAM discs, after being thermomechanically aged in a chewing simulator. A total of 112 stainless steel die models simulating mandibular left first molars were produced, 8 for each group. Single crowns were produced from 3 different discs (Grandio Voco [GR], breCAM HIPC [HC], and Shofu HC [SF]) by CAD/CAM milling method and manufactured from from 4 different permanent composite resins (Nexdent C&B MFH [ND], Permanent Bridge Saremco [PB], VarseoSmile Crownplus [VSC], and Şenertek P-Crown [PC]) using the 3D printing method. Stereomicroscopy, scanning electron microscope (SEM) and Finite Element Method (FEM) analysis was performed. Data were analyzed using ANOVA, paired-t tests and Tukey's HSD test (alpha = 0.05). As a result of thermomechanical aging, significant difference was found between the groups in wear and fracture resistance (P < .05). The highest wear resistance was found in the VSC group, and the lowest wear resistance in the PC group. As a result of the compression test, the highest fracture resistance was noted in the GR group and the lowest in the PC group. FEM analysis performed to validate fracture experiments showed an 87% similarity to the in-vitro data. The crowns in all groups produced by CAD/CAM milling and 3D printing provided acceptable in vitro wear and fracture resistance for clinical application. The wear and fracture resistance of resin-based materials should be supported by clinical studies.
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