Toshimitsu Niwa

Shubun University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Targeting protein-bound uremic toxins in chronic kidney disease

Expert Opinion on Therapeutic Targets (2013)

Toshimitsu Niwa

Introduction: Protein-bound uremic toxins such as indoxyl sulfate cannot be removed efficiently by hemodialysis. These protein-bound uremic toxins have emerged as important risk factors for the progression of chronic kidney disease (CKD) as well as cardiovascular disease (CVD). Areas covered: Indoxyl sulfate shows toxic effects on a variety of cells such as renal proximal tubular cells, glomerular mesangial cells, vascular smooth muscle cells, vascular endothelial cells, cardiomyocytes, cardiac fibroblasts, monocytes, osteoblasts and osteoclasts. This review overviews the cellular toxicity of indoxyl sulfate, its molecular mechanism and its role in the progression of CKD and CVD. Further, this review summarizes the clinical effects of AST-120 and the other strategies to reduce serum levels of indoxyl sulfate. Expert opinion: Protein-bound uremic toxins such as indoxyl sulfate have emerged as target molecules for therapeutic intervention of not only CKD but also CVD. An oral sorbent AST-120 reduces serum level of indoxyl sulfate by adsorbing indole in the intestine. The modulation of intestinal bacteria by prebiotics/probiotics might be effective in reducing the production of indole in the intestine followed by reduced serum levels of indoxyl sulfate. An alternative approach might be antagonist which can counteract indoxyl sulfate-induced cellular effects and signaling pathways.

Uremic Toxins

10.1517/14728222.2013.829456

Cite

Citations (33)

Chemical and Physiological Relevance of Glucose Degradation Products in Peritoneal Dialysis

Journal of Renal Nutrition (2011)

Stefan Mittelmaier Toshimitsu Niwa Monika Pischetsrieder

10.1053/j.jrn.2011.10.014

Cite

Citations (17)

Biocompatibility of hemodialysis membranes assessed on the basis of changes in gene expression and plasma interleukin-8 levels.

Nihon Toseki Igakkai Zasshi (1995)

Takashi Miyazaki Toshimitsu Niwa Motoyoshi Sato Tetsuya Tsuzuki Kanji Uema

インターロイキン8 (IL-8)は好中球, T cell, 好塩基球の遊走および刺激因子として働き, 炎症の媒体として重要な役割を果たしている. 透析中には血圧低下, 発熱, 掻痒のような無菌的な炎症性合併症の頻度が多く, その発症機序に炎症性細胞からのサイトカインの放出が関与している可能性がある. 血液透析 (HD) が血漿IL-8濃度にいかに作用するかを明らかにするため, 種々の透析膜を使用したHD前後の血漿IL-8濃度と末梢血単核球 (PBMC) におけるIL-8 mRNA発現について検討した. HD後の血漿lL-8濃度の上昇はTFα-1300 (RC), BK-1. 3P (PMMA), KF201-1200 (EVAL), Polyflux 130 (PA) において観察され, PAN-13DX (PAN), PS-1.3UW (PS), FB-130F (CTA) ではその変化は認められなかった. その際, PBMCにおけるIL-8 mRNA発現の変化は血漿濃度の変化に-致していた. また, 透析膜自身のIL-8の吸着性についても検討したところ, 吸着性を示したのはPANのみであった. 以上のことから, 透析膜の生体適合性の新しい指標としてIL-8が有用と考えられた.

Biocompatibility

10.4009/jsdt.28.59

Cite

Citations (0)

Uremia Research and Toxicity

Journal of Renal Nutrition (2015)

Shaul G. Massry Kunitoshi Iseki Toshimitsu Niwa

Uremia

10.1053/j.jrn.2014.11.003

Cite

Citations (0)

ChemInform Abstract: New Syntheses of 6‐Deoxy‐L‐gulose and 6‐Deoxy‐L‐talose.

ChemInform (1987)

Masami Mori S. TEJIMA Toshimitsu Niwa

Derivative (finance)

Catalytic hydrogenation

10.1002/chin.198716348

Cite

Citations (0)

Ischemic change of organic acids in kidney

Journal of Chromatography B Biomedical Sciences and Applications (1983)

Toshimitsu Niwa Naoya Yamamoto Hiroaki Asada Atsuko Kawanishi Masafumi Yokoyama

10.1016/s0378-4347(00)86124-1

Cite

Citations (5)

[SHORT REPORTS]Suppression of Cerebral Gene (UAB3) Expression under Uremia

Environmental medicine : annual report of the Research Institute of Environmental Medicine, Nagoya University (1994)

Takashi Miyazaki Yasuhiko Kanou Toshimitsu Niwa

Uremia

Source

Cite

Citations (0)

Indoxyl Sulfate Induces Endothelial Cell Senescence by Increasing Reactive Oxygen Species Production and p53 Activity

Journal of Renal Nutrition (2011)

Yelixiati Adelibieke Hidehisa Shimizu Gulinuer Muteliefu Dilinaer Bolati Toshimitsu Niwa

Senescence

10.1053/j.jrn.2011.10.027

Cite

Citations (69)

Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital.

Nagoya Journal of Medical Science/Nagoya journal of medical science (2004)

Kazuko Nishio Daisuke Tanaka Yoshiko Atsuta Kazuhito Yamamoto Akiko Tamakoshi

On June 9, 2003, we started free genetic tests of eight polymorphisms for health checkup examinees who attended a basic course at Nagoya University Hospital. They were informed of their genotypes within four weeks after blood donation for research purposes. The genotypes were those of alcohol dehydrogenase 2 (ADH2) Arg47His, aldehyde dehydrogenase 2 (ALDH2) Glu487Lys, NAD(P)H: quinone oxidoreductase (NQO1) C609T, glutathione S transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1), interleukin-1B (IL-1B) C-31T, and tumor necrosis factor A (TNF-A) T-1031C, angiotensin-converting enzyme (ACE) Ins/Del. In the first three months, 227 (89.4%) out of 254 examinees participated in the free tests, having been informed of the research aims, after which they consented to our use of research data. To date, there have been no complaints from the participants, indicating that the announcement of polymorphism genotypes may be accepted differently from that of hereditary disease genotypes.

ALDH2

Glutathione S-transferase

Source

Cite

Citations (4)

Reduced Circulating AGE Levels and Lower Genomic Damage in Patients Undergoing Daily versus Standard Hemodialysis

Annals of the New York Academy of Sciences (2005)

Evangelia Fragedaki Michael Nebel Nicole Schupp Katarı́na Šebeková Wolfgang Völkel

10.1196/annals.1333.139

Cite

Citations (1)