Iwona Radziejewska

Medical University of Białystok

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Małgorzata Borzym‐Κluczyk

Medical University of Białystok

Katarzyna Supruniuk

Gdańsk Medical University

A Gindzieński

Medical University of Białystok

Dariusz G. Kisiel

Medical University of Białystok

Z Namiot

Akademia Łomżyńska

Katarzyna Leszczyńska

Medical University of Białystok

Anna Bielawska

Medical University of Białystok

Joanna Wosek

Medical University of Białystok

J Darewicz

Medical University of Białystok

Anna Galicka

Medical University of Białystok

Cooperative Institutions

Medical University of Białystok

University Clinical Hospital In Bialystok

Center for Rheumatology

Akademia Łomżyńska

Bial (Portugal)

Instytut Farmaceutyczny

Jagiellonian University

Abt Associates (Nepal)

Białystok Institute of Cosmetology and Healthcare

Wojewódzki Szpital Zespolony im. Jędrzeja Śniadeckiego

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Characterisation of glycoforms of ascitic fluids in benign and malignant diseases

Clinical Biochemistry (2008)

Iwona Radziejewska Małgorzata Borzym‐Κluczyk Dariusz G. Kisiel Z Namiot Joanna Wosek

Fucosylation

Malignant disease

10.1016/j.clinbiochem.2008.09.114

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Citations (3)

The Effect of Helicobacter pylori Eradication Treatment on the MUC 1 and Lewis Antigens Level in Human Gastric Juice: Preliminary Study

Digestive Diseases and Sciences (2008)

Iwona Radziejewska Małgorzata Borzym‐Κluczyk Dariusz G. Kisiel Z Namiot Joanna Wosek

Spirillaceae

10.1007/s10620-008-0224-z

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Citations (8)

Disulfide-Bound Proteolytic Fragments of Gastric Mucin Are 100- and 140-kDa Proteins

Biochemical and Biophysical Research Communications (2000)

Iwona Radziejewska A Gindzieński Krzysztof Zwierz

Molecular mass

Proteolysis

Acetamide

Proteolytic enzymes

10.1006/bbrc.2000.2497

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Citations (10)

Tumor-associated carbohydrate antigens of MUC1 – Implication in cancer development

Biomedicine & Pharmacotherapy (2024)

Iwona Radziejewska

Glycosylation of cancerous epithelial MUC1 protein is specifically altered in comparison to that which is presented by healthy cells. One of such changes is appearing tumor-associated carbohydrate antigens (TACAs) which are rare in normal tissues and are highly correlated with poor clinical outcomes and cancer progression. This review summarizes and describes the role of Tn, T antigens, their sialylated forms as well as fucosylated Lewis epitopes in different aspects of tumor development, progression, and metastasis. Finally, applications of MUC1 glycan epitopes as potential targets for therapeutic strategy of cancers are notified. One of the novelties of this review is presentation of TACAs as inherently connected with MUC1 mucin.

MUC1

Tumor progression

10.1016/j.biopha.2024.116619

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Citations (5)

Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment

Clinical and Experimental Medicine (2010)

Iwona Radziejewska Małgorzata Borzym‐Κluczyk Z Namiot Ewa Stefańska

It is suggested that gastric mucins, and in particular some specific glycan structures that can act as carbohydrate receptors, are involved in the interactions with Helicobacter pylori adhesins. The main aim of our study was to evaluate glycosylation pattern of glycoproteins of gastric juice before and at the end of eradication therapy. Gastric juices were taken from 13 clinical patients and subjected to analysis. Pooled fractions of the void volume obtained after gel filtration were subjected to ELISA tests. To assess the relative amounts of carbohydrate structures, lectins and monoclonal antibodies were used. Changes in the level of MUC 1 and MUC 5AC mucins and of carbohydrate structures, which are suggested to be receptors for Helicobacter pylori adhesins, were observed by the end of the eradication treatment. Our results support the idea about the involvement of MUC 5AC and MUC 1 with some specific sugar structures in the mechanism of Helicobacter pylori infection.

Helicobacter

10.1007/s10238-010-0113-6

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Citations (12)

Anti-Cancer Potential of Afzelin towards AGS Gastric Cancer Cells

Pharmaceuticals (2021)

Iwona Radziejewska Katarzyna Supruniuk Robert Czarnomysy Kamila Buzun Anna Bielawska

Afzelin demonstrates anti-inflammatory and anti-cancer properties. Our purpose was to assess its influence on apoptosis, Bax, caspases, MUC1, cancer-related carbohydrate antigens, enzymes participating in their formation, and galectin-3 in AGS gastric cancer cells. A total of 60 and 120 μM afzelin was used in all experiments. Flow cytometry was applied to determine apoptotic response. Western blotting and RT PCR were used to detect the expression of mentioned factors. Flavonoid at higher concentration revealed slight apoptotic respond. Bax, caspase-3, -8, -9 increased upon afzelin action. Stimulatory effect of the flavonoid on MUC1 cytoplasmic tail and extracellular domain in cell lysates and on MUC1 gene was revealed. MUC1 release into the culture medium was inhibited by the flavonoid. The 60 μM afzelin dose stimulated GalNAcTL5 protein expression and inhibited C1GalT1. ST6GalNAcT mRNA was inhibited by both flavonoid doses. ST3GalT was inhibited by 120 μM afzelin on protein and mRNA level. Lewisa/b protein was reduced by both afzelin concentrations. FUT3 and FUT4 mRNA was inhibited by 120 μM dose of afzelin. Galectin-3 protein increased in cell lysates and decreased in culture supernatant by 60 and 120 μM flavonoid. Galectin-3 gene expression was stimulated by two used concentrations of afzelin in comparison to control. We conclude that afzelin can be considered as the potential anti-cancer agent, supporting conventional cancer treatment.

10.3390/ph14100973

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Citations (13)

MUC 1 mucin content in gastric juice of duodenal ulcer patients: effect of Helicobacter pylori eradication therapy

Clinical and Experimental Medicine (2007)

Iwona Radziejewska Dariusz G. Kisiel Małgorzata Borzym‐Κluczyk A. Kluz Z Namiot

Hematology

Spirillaceae

10.1007/s10238-007-0128-9

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Citations (3)

[The role of gastric mucins in interactions with Helicobacter pylori].

PubMed (2012)

Iwona Radziejewska

Helicobacter pylori is a Gram-negative bacterium which colonizes the stomach of over 50% of the world's population. The pathogen is responsible for many diseases including gastritis, ulcers and also gastric cancers. It is said that adherence of bacteria to epithelial cells plays a key role in infection development. Two gastric mucins, components of mucus, are assumed to have an important role in protection against adhesion and in this way in progression of infection. These are a secretory MUC5AC mucin, produced by mucous epithelial cells, and a membrane-bound MUC1 mucin, expressed by epical surfaces of epithelial cells. Interactions with bacteria occur between carbohydrate antigens of mucins and specific adhesins of the Helicobacter pylori surface. In this paper we present the latest knowledge about these intriguing interactions of both mucins and their interplay with the pathogen providing protection against infection.

Lactoferrin

MUC1

Source

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Citations (2)

Rosmarinic acid influences collagen, MMPs, TIMPs, glycosylation and MUC1 in CRL-1739 gastric cancer cell line

Biomedicine & Pharmacotherapy (2018)

Iwona Radziejewska Katarzyna Supruniuk Jolanta Nazaruk Ewa Karna Bożena Popławska

MUC1

10.1016/j.biopha.2018.07.123

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Citations (32)

Rosmarinic Acid: A Potential Therapeutic Agent in Gastrointestinal Cancers Management—A Review

Karolina Czerwińska Iwona Radziejewska

Gastrointestinal cancers are still the leading cause of death worldwide. This is related, among other things, to non-specific symptoms, especially in the initial stages, and also to limited possibilities of treatment. Therefore, research is still being conducted to improve the detection of this type of cancer and increase the effectiveness of therapy. The potential application of natural compounds in cancer management deserves special attention. In the group of such products there are polyphenolic compounds which reveal e.g. anti-oxidative, anti-carcinogenic, anti-inflammatory, anti-diabetic and neuroprotective properties. One of such polyphenols is rosmarinic acid, commonly found in plants such as Boraginaceae and Nepetoideae subfamilies of the Lamiaceae (mint) family, including Origanum vulgare, Rosmarinus officinalis Thymus masticmasti chinaythia koreana, Ocimum sanctum, and Hyptis pectinate. A number of studies considers the positive effects of rosmarinic acid in the treatment of many cancers, including gastrointestinal ones such as oral, stomach, pancreas, colon, and liver. The main aim of this paper was to focus on the summarized mechanisms of the action of rosmarinic acid in gastrointestinal cancers.

Rosmarinic acid

10.20944/preprints202409.2302.v1

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Citations (1)