Maurizio Castelli

University of Aosta Valley

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Giovanna Tagliabue

Fondazione IRCCS Istituto Nazionale dei Tumori

Lorenza Boschetti

Institut des Sciences de la Terre

Paolo Contiero

Fondazione IRCCS Istituto Nazionale dei Tumori

Stefano Trione

Instituto Argentino de Investigaciones de las Zonas Aridas

Inea

Stefano Palumbo

Team (Italy)

Ilaria Borri

Giulio Barigelletti

Fondazione IRCCS Istituto Nazionale dei Tumori

Alberto Sturla

Cereal Research Centre

Claudia Cirilli

Azienda Unita' Sanitaria Locale Di Modena

Cooperative Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

Fondazione IRCCS Istituto Nazionale dei Tumori

London School of Hygiene & Tropical Medicine

University of Bologna

Azienda Sanitaria Unità Locale di Reggio Emilia

Policlinico S.Orsola-Malpighi

University of Milan

University of Udine

Istituto di Ematologia di Bologna

ASL Roma

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Indagine sull’impiego degli immigrati in agricoltura in Italia, 2010

Inea Manuela Cicerchia Ilaria Borri Stefano Trione Maurizio Castelli

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Excess risk of subsequent malignant neoplasms in adolescent and young adult cancer survivors: Results from the first Italian population‐based cohort

Cancer (2021)

Annalisa Trama Andrea Tittarelli Giulio Barigelletti Laura Botta Gemma Gatta

Background Evidence about late effects in adolescent and young adult (AYA) cancer survivors is scarce. This study assessed the risk of subsequent malignant neoplasms (SMNs) to identify the most common SMNs to be considered in follow‐up care. Methods Population‐based cancer registries retrospectively identified first primary tumors (between 1976 and 2013) and SMNs in AYAs (15‐39 years old at their cancer diagnosis). AYA cancer survivors were those alive at least 5 years after their first cancer diagnosis. The excess risk of SMNs was measured as standardized incidence ratios (SIRs) and absolute excess risk together with the cumulative incidence of SMNs. Results The cohort included 67,692 AYA cancer survivors. The excess risk of developing any SMN (SIR, 1.6; 95% confidence interval, 1.5‐1.7) was 60%. The excess risk of SMNs was significantly high for survivors of lymphomas; cancers of the breast, thyroid, female genital tract, digestive organs, gonads, and urinary tract; and melanomas. The cumulative incidence of all SMNs in AYA cancer survivors within 25 years of their first cancer diagnosis was approximately 10%. Subsequent tumors contributing to approximately 60% of all SMNs were breast cancer, colorectal cancer, corpus uteri cancer, and ovarian cancer in females and colorectal cancer, bladder cancer, prostate cancer, lung cancer, and lymphomas in males. Conclusions These results highlight the need to personalize follow‐up strategies for AYA cancer survivors.

Uterine cancer

Cumulative incidence

10.1002/cncr.33931

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Causes of death in women with breast cancer: a risks and rates study on a population-based cohort

Frontiers in Oncology (2023)

Paolo Contiero Roberto Boffi Alessandro Borgini Sabrina Fabiano Andrea Tittarelli

The increasing survival of patients with breast cancer has prompted the assessment of mortality due to all causes of death in these patients. We estimated the absolute risks of death from different causes, useful for health-care planning and clinical prediction, as well as cause-specific hazards, useful for hypothesis generation on etiology and risk factors.Using data from population-based cancer registries we performed a retrospective study on a cohort of women diagnosed with primary breast cancer. We carried out a competing-cause analysis computing cumulative incidence functions (CIFs) and cause-specific hazards (CSHs) in the whole cohort, separately by age, stage and registry area.The study cohort comprised 12,742 women followed up for six years. Breast cancer showed the highest CIF, 13.71%, and cardiovascular disease was the second leading cause of death with a CIF of 3.60%. The contribution of breast cancer deaths to the CIF for all causes varied widely by age class: 89.25% in women diagnosed at age <50 years, 72.94% in women diagnosed at age 50-69 and 48.25% in women diagnosed at age ≥70. Greater CIF variations were observed according to stage: the contribution of causes other than breast cancer to CIF for all causes was 73.4% in women with stage I disease, 42.9% in stage II-III and only 13.2% in stage IV. CSH computation revealed temporal variations: in women diagnosed at age ≥70 the CSH for breast cancer was equaled by that for cardiovascular disease and "other diseases" in the sixth year following diagnosis, and an early peak for breast cancer was identified in the first year following diagnosis. Among women aged 50-69 we identified an early peak for breast cancer followed by a further peak near the second year of follow-up. Comparison by geographic area highlighted conspicuous variations: the highest CIF for cardiovascular disease was more than 70% higher than the lowest, while for breast cancer the highest CIF doubled the lowest.The integrated interpretation of absolute risks and hazards suggests the need for multidisciplinary surveillance and prevention using community-based, holistic and well-coordinated survivorship care models.

10.3389/fonc.2023.1270877

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Epidemiology of Soft Tissue Sarcoma and Bone Sarcoma inItaly: Analysis of Data from 15 Population-Based Cancer Registries

Sarcoma (2020)

Sabrina Fabiano Paolo Contiero Giulio Barigelletti Anna D’Agostino Andrea Tittarelli

Sarcomas are a heterogeneous group of rare cancers of mesenchymal origin. In this study, we provide updated, world age-standardised incidence rate (ASR) and European age-standardised incidence rate for malignant soft tissue sarcoma (ICD-O-3 topographic code C47–C49) and bone sarcoma (C40, C41) in Italy, by area (north, centre, and south) and by cancer registry. We also assess morphology in relation to site and area and assess metastases at diagnosis. We analysed 1,112 cases, with incidence 2009–2012, provided by 15 cancer registries (CRs) affiliated to the Association of Italian Cancer Registries (AIRTUM). Overall, ASR was 1.7/100,000/year for soft tissue sarcoma and 0.7 for bone sarcoma. Central Italy had the highest (2.4) ASR and south Italy had the lowest (1.6) ASR for soft tissue sarcoma. Central Italy had the highest (1.1) ASR and north Italy had the lowest (0.7) ASR for bone sarcoma. By CR, ASRs ranged from 1.1 to 2.6 for soft tissue sarcoma and from 0 to 1.4 for bone sarcoma. The most frequent soft tissue sarcomas were sarcoma not otherwise specified (NOS) (29.4%) and liposarcoma (22.2%); the most common bone sarcoma was chondrosarcoma (37.6%). Soft tissue sarcomas occurred most frequently (35.6%) in lower limb connective tissue; bone sarcomas arose mainly (68.8%) in long bones. The frequencies of morphologies arising at different sites varied considerably by Italian area; for example, 20% of hemangiosarcomas occurred in the head and neck in south Italy with 17% at this site in the centre and 6% in the north. For soft tissue sarcoma, the highest ASRs of 2.6 and 2.4 contrast with the lowest ASRs 1.1 and 1.3, suggesting high-risk hot spots that deserve further investigation. The marked variations in morphology distribution with site and geography suggest geographic variation in risk factors that may also repay further investigation particularly since sarcoma etiology is poorly understood.

Bone Sarcoma

Bone cancer

Undifferentiated Pleomorphic Sarcoma

10.1155/2020/6142613

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Indagine sull’impiego degli immigrati in agricoltura in Italia. 2011

Inea Manuela Cicerchia Domenico Pavone Ilaria Borri Stefano Trione

Obiettivo della pubblicazione e stimare l'impiego dei lavoratori stranieri in agricoltura in tutto il territorio nazionale, tenendo conto delle diversita esistenti a carattere regionale.

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L'agricoltura lombarda conta. 2014, (5. ed.)

Inea Regione Lombardia. Dipartimento Agricoltura Sabrina Giuca Maria Silvia Giannini Alessandro Nebuloni

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Cancer registries and data protection in the age of health digital interoperability in Europe: The perspective of the Italian Network of Cancer Registries (AIRTUM)

Frontiers in Oncology (2022)

Walter Mazzucco Fabrizio Stracci Gemma Gatta Angelo D’Argenzio Ettore Bidoli

OPINION article Front. Oncol., 06 December 2022Sec. Cancer Epidemiology and Prevention Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.1052057

Health data

10.3389/fonc.2022.1052057

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Influence of Sex and Age on Site of Onset, Morphology, and Site of Metastasis in Colorectal Cancer: A Population-Based Study on Data from Four Italian Cancer Registries

Cancers (2023)

Viviana Perotti Sabrina Fabiano Paolo Contiero Maria Michiara Antonino Musolino

The prognosis of colorectal cancer is affected by factors such as site of origin, tumor morphology, and metastasis at diagnosis, but also age and sex seem to play a role. This study aimed to investigate within the Italian population how sex and age interact in influencing certain aspects of the disease and how they affect patient survival, particularly in the metastatic cohort. Data from four cancer registries were collected, and patients were classified by sex and age (<50, 50-69, and >69 years). Two separate analyses were conducted: one for patients having right or left colon cancer with adenocarcinoma or mucinous morphology, and one for patients having metastases at diagnosis. Women showed significant differences in right colon cases from the youngest to oldest age group (36% vs. 45% vs. 60%). Men <50 years had a significantly higher mucinous carcinoma percentage than their female counterparts (22% vs. 11%), while in the oldest age group women had the highest percentage (15% vs. 11%). The metastatic pattern differed between men and women and by age. The three-year relative survival in the <50 age group was better for women than men, but this survival advantage was reversed in the oldest group. In conclusion, sex and age are factors that influence the biological and clinical characteristics of colorectal cancer, affecting the metastatic pattern as well as patient survival.

Relative survival

10.3390/cancers15030803

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Molecular Subtypes, Metastatic Pattern and Patient Age in Breast Cancer: An Analysis of Italian Network of Cancer Registries (AIRTUM) Data

Journal of Clinical Medicine (2021)

Giovanna Tagliabue Sabrina Fabiano Paolo Contiero Giulio Barigelletti Maurizio Castelli

Breast cancer stage at diagnosis, patient age and molecular tumor subtype influence disease progression. The aim of this study was to analyze the relationships between these factors and survival in breast cancer patients among the Italian population using data from the AIRTUM national database. We enrolled women with primary breast cancer from 17 population-based cancer registries. Patients were subdivided into older (>69 years), middle (50-69 years) and younger age groups (<50 years) and their primary tumors categorized into four molecular subtypes based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status. There were 8831 patients diagnosed between 2010 and 2012 included. The most represented age group was 50-69 years (41.7%). In 5735 cases the molecular subtype was identified: HER2-/HR+ was the most frequent (66.2%) and HER2+/HR- the least (6.2%). Of the 390 women with metastases at diagnosis, 38% had simultaneous involvement of multiple sites, independent of age and molecular profile. In women with a single metastatic site, bone (20% of cases), liver (11%), lung (7%) and brain (3%) were the most frequent. In the studied age groups with different receptor expression profiles, the tumor metastasized to target organs with differing frequencies, affecting survival. Five-year survival was lowest in women with triple-negative (HER2-/HR-) tumors and women with brain metastases at diagnosis.

Primary tumor

10.3390/jcm10245873

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Fludarabine Based Regimen (FLAI) Is an Effective Treatment for Induction of Multidrug Resistant Pgp-Positive Acute Myeloid Leukemia Patients.

Blood (2005)

Domenico Russo Daniela Damiani Michele Malagola Antonio De Vivo M Fiacchini

Regimen

Daunorubicin

10.1182/blood.v106.11.1857.1857

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Citations (2)