Deanna Horvath

La Trobe University

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Amy Larsen

University of Washington

Robyn M. Murphy

La Trobe University

Dawson J. Kidgell

Monash University

Emma Stirling

Australian Catholic University

Adrienne Forsyth

Australian Catholic University

Ashlyn K. Frazer

Monash University

Alan J. Pearce

Swinburne University of Technology

Sharon Croxford

Australian Catholic University

Phil Buultjens

La Trobe University

Melissa Buultjens

La Trobe University

Cooperative Institutions

La Trobe University

University of Melbourne

Monash University

Deakin University

Victoria University

Australian National University

Australian Institute for Musculoskeletal Science

Australian Catholic University

Institute of Zoology

Australian Regenerative Medicine Institute

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Enhancing student transition to university

Routledge eBooks (2024)

Kathy Egea Katie Padilla Jason Do Deanna Horvath Christopher Bridge

This chapter examines the design, implementation and impact of innovative pre-arrival platforms for students transitioning to university, within an Australian context. The platforms feature a collaborative university-wide programme aimed at onboarding international students; a faculty-driven students–staff co-design approach for commencing international students; and a subject level approach specifically tailored for transition success, particularly for students from equity backgrounds. These pre-arrival initiatives showcase innovative strategies to foster student identity, capacity, confidence, overall well-being and integration into the university landscape. By analysing each practice, the chapter identifies opportunities for novel and effective approaches across the academic–student support interface. To ensure more cohesive and continuous seamless student transition with pre-arrival platforms, the study emphasises the importance of sustainable partnerships and collaborations in creating a connective ecosystem within universities to drive innovative practices.

10.4324/9781003427575-17

Cite

Citations (0)

Ca²⁺‐dependent proteolysis of junctophilin‐1 and junctophilin‐2 in skeletal and cardiac muscle

The Journal of Physiology (2012)

Robyn M. Murphy T. L. Dutka Deanna Horvath James R. Bell L.M.D. Delbridge

Excessive increases in intracellular [Ca(2+)] in skeletal muscle fibres cause failure of excitation-contraction coupling by disrupting communication between the dihydropyridine receptors in the transverse tubular system and the Ca(2+) release channels (RyRs) in the sarcoplasmic reticulum (SR), but the exact mechanism is unknown. Previous work suggested a possible role of Ca(2+)-dependent proteolysis in this uncoupling process but found no proteolysis of the dihydropyridine receptors, RyRs or triadin. Junctophilin-1 (JP1; ∼90 kDa) stabilizes close apposition of the transverse tubular system and SR membranes in adult skeletal muscle; its C-terminal end is embedded in the SR and its N-terminal associates with the transverse tubular system membrane. Exposure of skeletal muscle homogenates to precisely set [Ca(2+)] revealed that JP1 undergoes Ca(2+)-dependent proteolysis over the physiological [Ca(2+)] range in tandem with autolytic activation of endogenous μ-calpain. Cleavage of JP1 occurs close to the C-terminal, yielding a ∼75 kDa diffusible fragment and a fixed ∼15 kDa fragment. Depolarization-induced force responses in rat skinned fibres were abolished following 1 min exposure to 40 μm Ca(2+), with accompanying loss of full-length JP1. Supraphysiological stimulation of rat skeletal muscle in vitro by repeated tetanic stimulation in 30 mm caffeine also produced marked proteolysis of JP1 (and not RyR1). In dystrophic mdx mice, JP1 proteolysis is seen in limb muscles at 4 and not at 10 weeks of age. Junctophilin-2 in cardiac and skeletal muscle also undergoes Ca(2+)-dependent proteolysis, and junctophilin-2 levels are reduced following cardiac ischaemia-reperfusion. Junctophilin proteolysis may contribute to skeletal muscle weakness and cardiac dysfunction in a range of circumstances.

Proteolysis

Cardiac muscle

Triad (sociology)

Sarcoplasm

10.1113/jphysiol.2012.243279

Cite

Citations (113)

Plasma testosterone fractions in women with hyperandrogenism

13th European Congress of Endocrinology (2011)

E Toldy Deanna Horvath Z Locsei Károly Rácz Györgyi Kovács

Hyperandrogenism

Source

Cite

Citations (0)

Galanin Receptor Agonists Limit Osteoclast Number in in Vitro Mouse Models

Heath McGowan Deanna Horvath Amy Larsen Aaron C. McDonald

Galanin receptor

10.2139/ssrn.5017779

Cite

Citations (0)

‘Get Ready’: Improving the Transition Experience of a Diverse First Year Cohort Through Building Student Agency

Student Success (2019)

Amy Larsen Deanna Horvath Christopher Bridge

A great deal has been achieved in recent years in understanding how universities can best support the transition to higher education of an increasingly diverse student body (Kift, 2015). Numerous studies have identified transition program elements that correlate with improved success and retention for commencing students. Lizzio’s ‘five senses’ model (2006) rationalises these diverse features into a framework consisting of five affective domains that need to be developed in students to ensure successful transition. To assess how well a program based on the Lizzio model supports transition in practice, we evaluate our Get Ready transition program, developed for a large-enrolment first year Human Physiology subject with a highly diverse student cohort. We conclude that embedding the development of Lizzio’s five senses in a performative way is the key to building students’ agency and nurturing their identity as thriving members of a new academic community.

Thriving

10.5204/ssj.v11i3.1144

Cite

Citations (18)

The effect of taurine on dystrophic muscle tissue function

Deanna Horvath

Duchenne muscular dystrophy (DMD) is a lethal X-linked genetic disorder which results in chronic degeneration of skeletal muscle, significantly impacting on the duration and quality of life. Despite the genetic defect and the missing protein dystrophin having been identified and characterised over 20 years ago, curative genetic therapies are still not clinically applicable, and corticosteroids, which are the only significantly beneficial treatment option currently available to DMD patients, are associated with several side-effects. Thus, there is a need for additional therapeutic interventions that can improve skeletal muscle function and delay the onset of severe pathology in dystrophy. The amino acid taurine is essential for normal skeletal muscle function, and has been shown to act on several factors thought to be key contributors to the development of skeletal muscle pathology in dystrophy. Moreover, as dystrophic skeletal muscle demonstrates a significant decrease in taurine content, it is possible that raising intramuscular taurine stores may preserve muscle function in dystrophy, and thus have potential therapeutic applications. Despite this, only two studies have ever examined the effect of taurine supplementation on dystrophic muscle function. The purpose of this thesis was to examine the effect of taurine on dystrophic skeletal muscle function, which was performed in three studies using the dystrophic mdx mouse as a model for DMD.

mdx mouse

Muscle disorder

Dystrophy

ITGA7

Source

Cite

Citations (2)

Effect of Six Weeks of Dura Disc and Mini-Trampoline Balance Training on Postural Sway in Athletes With Functional Ankle Instability

The Journal of Strength and Conditioning Research (2007)

Dawson J. Kidgell Deanna Horvath Brendan Mark. Jackson Philip J. Seymour

Lateral ankle sprain (LAS) is one of the most common injuries incurred during sporting activities, and effective rehabilitation programs for this condition are challenging to develop. The purpose of this research was to compare the effect of 6 weeks of balance training on either a mini-trampoline or a dura disc on postural sway and to determine if the mini-trampoline or the dura disc is more effective in improving postural sway. Twenty subjects (11 men, 9 women) with a mean age of 25.4 +/- 4.2 years were randomly allocated into a control group, a dura disc training (DT) group, or a mini-trampoline (MT) group. Subjects completed 6 weeks of balance training. Postural sway was measured by subjects performing a single limb stance on a force plate. The disbursement of the center of pressure was obtained from the force plate in the medial-lateral and the anterior-posterior sway path and was subsequently used for pretest and posttest analysis. After the 6-week training intervention, there was a significant (p < 0.05) difference in postural sway between pre- and posttesting for both the MT (pretest = 56.8 +/- 20.5 mm, posttest = 33.3 +/- 8.5 mm) and DT (pretest = 41.3 +/- 2.6 mm, posttest = 27.2 +/- 4.8 mm) groups. There was no significant (p > 0.05) difference detected for improvements between the MT and DT groups. These results indicate that not only is the mini-trampoline an effective tool for improving balance after LAS, but it is equally as effective as the dura disc.

Trampoline

Force platform

Balance training

10.1519/r-18945.1

Cite

Citations (95)

Plan, prepare and connect: How investing in understanding and tracking the evolving needs of online students informs the development of targeted programs for transition and success

Journal of University Teaching and Learning Practice (2019)

Deanna Horvath Emma Stirling John Bevacqua Mikael Coldrey Phil Buultjens

Growth in online higher education offerings has been significant in recent years, with many Australian Universities launching programs to extend into new markets and meet the student demand for greater flexibility in delivery modes. Further, it is well understood that good support is an essential component to student success, satisfaction and retention. Despite this, orientation, including non-academic support, is often overlooked in online education systems. Therefore, the current study aimed to develop an orientation program to increase student preparedness and facilitate ongoing support, in addition to developing evidence-based best-practice strategies to support academic’s when developing new online courses.

Preparedness

Tracking (education)

Best practice

10.53761/1.16.1.4

Cite

Citations (13)

Successful team-based development of an online course with an external partner: An analysis of the perspectives of academics

Sharon Croxford Colleen J. Thomas Deanna Horvath Melissa Buultjens Emma Stirling

Course and subject development teams are increasingly seen in the tertiary online teaching environment and they face a unique set of challenges. The purpose of this study was to synthesise and share learnings of 12 academics involved in the development of subjects with an external partner for a new multidisciplinary online health science course at an Australian university, in order to improve ongoing development within the course and inform new course development. In this case study, thematic analysis of focus group discussions and qualitative survey data identified five key themes related to the development process: time management, setting expectations, communication, the development team, and ownership. Barriers to productive subject development included unrealistic timelines, unclear lines of communication, unmet or unrealistic expectations and lack of recognition of team members’ expertise, and lack of support for genuine collaboration. Team-based development of an online course has the potential to be a rewarding experience for academics. In order for the benefits to be realised, approaches to development underpinned by a community-centred framework, observing core values such as collaboration, shared sense of purpose and expectations, would address a number of the issues identified in this study.

Thematic Analysis

Time line

Leadership Development

Online discussion

10.14453/jutlp.v16i1.5

Cite

Citations (1)

Adaptations in corticospinal excitability and inhibition are not spatially confined to the agonist muscle following strength training

European Journal of Applied Physiology (2017)

Joel Mason Ashlyn K. Frazer Deanna Horvath Alan J. Pearce Janne Avela

Strength Training

Corticospinal tract

Biceps brachii muscle

10.1007/s00421-017-3624-y

Cite

Citations (29)