Wataru Yano

National Defense Medical College

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Enforced expression of human ANGPTL2 impaired glucose and insulin tolerance in mice.

Yusuke Sasaki Ohta Masayuki Desai Dhruv Figueiredo Jose-Luiz C. Whelan Mary

Glucose tolerance test

10.1371/journal.pone.0131176.g001

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Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways

Journal of Biological Chemistry (2006)

Naoto Kubota Yasuo Terauchi Tetsuya Kubota Hiroki Kumagai Shinsuke Itoh

Thiazolidinediones have been shown to up-regulate adiponectin expression in white adipose tissue and plasma adiponectin levels, and these up-regulations have been proposed to be a major mechanism of the thiazolidinedione-induced amelioration of insulin resistance linked to obesity. To test this hypothesis, we generated adiponectin knock-out (adipo-/-) ob/ob mice with a C57B/6 background. After 14 days of 10 mg/kg pioglitazone, the insulin resistance and diabetes of ob/ob mice were significantly improved in association with significant up-regulation of serum adiponectin levels. Amelioration of insulin resistance in ob/ob mice was attributed to decreased glucose production and increased AMP-activated protein kinase in the liver but not to increased glucose uptake in skeletal muscle. In contrast, insulin resistance and diabetes were not improved in adipo-/-ob/ob mice. After 14 days of 30 mg/kg pioglitazone, insulin resistance and diabetes of ob/ob mice were again significantly ameliorated, which was attributed not only to decreased glucose production in the liver but also to increased glucose uptake in skeletal muscle. Interestingly, adipo-/-ob/ob mice also displayed significant amelioration of insulin resistance and diabetes, which was attributed to increased glucose uptake in skeletal muscle but not to decreased glucose production in the liver. The serum-free fatty acid and triglyceride levels as well as adipocyte sizes in ob/ob and adipo-/-ob/ob mice were unchanged after 10 mg/kg pioglitazone but were significantly reduced to a similar degree after 30 mg/kg pioglitazone. Moreover, the expressions of TNFalpha and resistin in adipose tissues of ob/ob and adipo-/-ob/ob mice were unchanged after 10 mg/kg pioglitazone but were decreased after 30 mg/kg pioglitazone. Thus, pioglitazone-induced amelioration of insulin resistance and diabetes may occur adiponectin dependently in the liver and adiponectin independently in skeletal muscle.

Pioglitazone

Thiazolidinedione

Glucose clamp technique

10.1074/jbc.m505649200

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Citations (318)

Studies on the Synthesis and the Applications of Polyalkylene Glycol Derivatives. II

Yukagaku (1969)

Masanori Matsuda Noriyuki Kawamura Wataru Yano Wasaburo KIMURA

A series of sodium polyoxypropylated lauryl sulfates (PPLS, adducts of 1, 3, 5, 10, 15 and 20 mol of propylene oxide) was synthesized and the change in their surface activities such as surface tension, foaming properties, wetting power, dispersing power and emulsifying power, by the difference in the number of moles of propylene oxide added, was discussed in comparison with sodium lauryl sulfate (SLS).The surface tension and the cmc values of PPLS are lower than those of SLS. The foaming power and the foam stability of PPLS, excluding the case of 1 mol adduct, are inferior to those of SLS. The wetting, dispersing and emulsifying powers of PPLS having more than 3 mol of propylene oxide are superior to those of SLS.PPLS are generally excellent surfactants.

Propylene oxide

Polyvinyl Alcohol

Sodium sulfate

10.5650/jos1956.18.132

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Citations (1)

Smaller posterior semicircular canals are associated with leaping in Colobus

The 84th Annual Meeting of the American Association of Physical Anthropologists, St. Louis, MO (2015)

Todd C. Rae Paul M. Johnson Wataru Yano Eishi Hirasaki

Source

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Development of indentation tester designed for characterizing soft biological tissues

The Proceedings of Conference of Chugoku-Shikoku Branch (2020)

Wataru Yano Atsutaka TAMURA

Indentation

10.1299/jsmecs.2020.58.01b4

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Studies on the Analysis of Surface Active Agents. XXXI.

Yukagaku (1974)

Yukio KASAI Wataru Yano Wasaburo KIMURA

A rapid method for the determination of ethylene oxide contents in POE type nonionic surfactants by near-infrared (NIR) spectroscopy was established.POE type nonionic surfactants have strong absorption at 1.42μ and 1.74μ in near-infrared region. The band at 1.42μ is the O-H stretching vibration, and the band at 1.74μ is the first overtone of the C-H stretching vibration. The linear relationship is obtained between the absorbance ratio a1.74/a1.42 and EO contents of POE type nonionics. The absorbance ratio is not affected by concentration (0.21.2g/50ml) and by temperature (8°38°C) of the sample solution.Based on these facts, in this method, a 0.7 to 1.0g of nonionics sample was dissolved into 50ml of carbon tetrachloride solution. The solution was mesured by NIR from 1.2 to 2.0μ in 10cm silica cell. The absorbances were obtained from peak-height of the band at 1.42 and 1.74μ. The EO contents was calculated from the absorbance ratio and the calibration curve.This method allows determination of the EO contents in POE type nonionics within relative accuracy of 3.5% until about 30 moles.

Absorbance

10.5650/jos1956.23.37

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Development of Cranial Morphology in Two Subspecies of Japanese Macaque (Macaca fuscata)

Wataru Yano

Subspecies

Morphology

Source

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Dental metric variability associated with human migration from skeletal remains of two Jomon sites (Yoshigo and Inariyama) in the Atsumi Peninsula area

Anthropological Science (2012)

Wataru Morita Sōichirō Kusaka Wataru Yano Masato Nakatsukasa

This study investigated interpopulation genetic relationships in the Jomon Atsumi Peninsula area, comparing the pattern of human migration revealed by strontium isotope ratio with dental metric variation of Yoshigo and Inariyama skeletal remains. Morphological differences were evaluated between the local and immigrant groups to determine whether or not local populations had become completely homogenized by human migration. We have constructed 4 × 4 contingency tables consisting of four clusters derived from K-means clustering of dental measurements and four groups (immigrants and locals of the two sites), and evaluated their correlations by Fisher’s exact test. The results revealed that human migration pattern was significantly correlated with dental metric variation, suggesting that there was regional heterogeneity among Jomon populations in the Atsumi Peninsula area. Although the distinction between immigrants and locals of Yoshigo and Inariyama populations based on strontium isotope analysis was not completely in accord with dental metric variability, most of the identified immigrants exhibited dental profiles that were beyond each local profile as determined using principal component analysis. Furthermore, the dental metric variances of the immigrants were significantly larger than those of the locals, suggesting multiple origins. The microdifferentiation among populations in the Atsumi Peninsula area may suggest nonrandom kin-structured migration and/or population aggregation from surrounding areas.

Peninsula

Geographical distance

10.1537/ase.110428

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Citations (4)

Supplementary Table 4 from Cranial shape evolution in adaptive radiations of birds: comparative morphometrics of Darwin's finches and Hawaiian honeycreepers

Figshare (2016)

Masayoshi Tokita Wataru Yano Helen F. James Arhat Abzhanov

A list of skeletal specimens analyzed in this study, along with information about catalogue number and sex (male or female).

Morphometrics

Table (database)

10.6084/m9.figshare.4220181