Noorul Balqis Che Ibrahim

Hospital Universiti Sains Malaysia

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Maya Mazuwın Yahya

Universiti Sains Malaysia

Mohd Fazrin Mohd Rohani

Hospital Kuala Lumpur

Faezahtul Arbaeyah Hussain

Hospital Universiti Sains Malaysia

Wan Faiziah Wan Abdul Rahman

Universiti Sains Malaysia

Azzahra Azhar

Hospital Universiti Sains Malaysia

Chee Lee Wee

Universiti Sains Malaysia

Nik Soriani Yaacob

Universiti Sains Malaysia

Seng Kong Tham

Izyan Rifhana Muhamad

Universiti Sains Malaysia

Wan Mohd Nazlee Wan Zainon

Hospital Universiti Sains Malaysia

Cooperative Institutions

Universiti Sains Malaysia

Hospital Universiti Sains Malaysia

Universiti Malaysia Kelantan

Hospital Kuala Lumpur

Ministry of Health

Sarawak General Hospital

Hospital Raja Perempuan Zainab II

Klinik und Poliklinik für Nuklearmedizin

Essen University Hospital

University of Mississippi Medical Center

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Synchronous Breast and Cervical Carcinoma: A Genetic Point of View

Biomedicines (2023)

Maya Mazuwın Yahya Mohd Pazudin Ismail Shogeta Ramanathan Muhammad Nashriq Kadir Azzahra Azhar

Breast carcinoma is the most common cancer of women in Malaysia. The most common sites of metastasis are the lung, liver, bone and brain. A 45-year-old lady was diagnosed with left invasive breast carcinoma stage IV (T4cN1M1) with axillary lymph nodes and lung metastasis. She was noted to have a cervical mass through imaging, and biopsy showed CIN III. Post chemotherapy, the patient underwent left simple mastectomy with examination under anaesthesia of the cervix, cystoscopy and staging. The cervical histopathological examination (HPE) showed squamous cell carcinoma, and clinical staging was 2A. The breast tissue HPE showed invasive carcinoma with triple receptors positivity. The patient was given tamoxifen and put on concurrent chemoradiotherapy (CCRT) for the cervical cancer. The management of each pathology of this patient involved a multi-disciplinary team that included surgeons, oncologists, gynaecologists, pathologists and radiologists. Due to the complexity of the case with two concurrent cancers, the gene expression profiles may help predict the patient's clinical outcome.

10.3390/biomedicines11020525

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Evaluation of Signal Transducer and Activator of Transcription 3 (STAT-3) Protein Expression in Non-Hodgkin Lymphoma Cases in Hospital USM

Diagnostics (2023)

Izyan Rifhana Muhamad Noorul Balqis Che Ibrahim Faezahtul Arbaeyah Hussain

Evolving targeted therapy on Janus Associated Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signaling pathway, especially pertaining to STAT-3 protein in non-Hodgkin lymphoma (NHL), provides new treatment strategies. STAT-3 protein also relates to the prognostication of NHL. Hence, we aimed to evaluate the expression of STAT-3 protein in NHL cases diagnosed in Hospital Universiti Sains Malaysia (USM).A retrospective cross sectional study using formalin fixed paraffin embedded (FFPE) tissue blocks of 95 NHL cases were obtained. STAT-3 immunostaining was performed and evaluated. The proportion and association between the expression of STAT-3 protein with subtypes of NHL were statistically analyzed.The majority of the cases (78.9%) had positive STAT-3 protein expression. 64.2% were among aggressive B cell NHL, whilst 20.0% of them were diffuse large B cell lymphoma, a non-germinal center B subtype (DLBCL-NGCB). There is also an association between STAT-3 protein expression with DLBCL subtypes (p = 0.046).Our study demonstrated a remarkable expression of STAT-3 protein in NHL, in which DLBCL subtypes had significant association. A larger scale study with a combination of JAK protein evaluation should be undertaken in the future.

STAT4

STAT6

Immunostaining

10.3390/diagnostics13091649

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Camouflaged Asymptomatic Mediastinal Thyroid Ectopia in a Patient with Toxic Goiter: A Case Report

World Journal of Endocrine Surgery (2023)

Mohd Fazrin Mohd Rohani İrfan Mohamad Wan Mohd Nazlee Wan Zainon Wan Faiziah Wan Abdul Rahman Ahmad Ali

CASE REPORTwithin measuring approximately 5.3 × 3.6 × 5.1 cm (AP × W × CC), which appears to be clearly separated from the thyroid gland IntroductIon4][5][6] We present a case of mediastinal ectopic thyroid, which was incidentally detected on imaging during preoperative workup for total thyroidectomy and was later characterized by thyroid scintigraphy prior to surgical removal.

10.5005/jp-journals-10002-1444

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Uterine Epithelioid Leiomyosarcoma Arising Within Leiomyoma in A Postmenopausal Woman: A Case Report

Malaysian Journal of Medicine and Health Sciences (2023)

Engku Husna Engku Ismail Noorul Balqis Che Ibrahim Mohd Hafizuddin Husin Sharifah Emilia Tuan Sharif

Uterine leiomyosarcoma is a malignant smooth muscle tumour of the uterus. It is rare and accounting for less than 2% of cases in malignant gynaepathology. To date, only a few reported cases of leiomyosarcoma arising from leiomyoma documented in the literature. We shared an uncommon occurrence of leiomyosarcoma arising from leiomyoma. Presented herein is a case of a ‘rare epithelioid subtype’ of leiomyosarcoma arising from a leiomyoma in a postmenopausal woman. We highlighted the importance of recognizing the possibilities of this event to allow for a timely diagnosis of leiomyosarcoma and to provide insights on management of patients presented with clinically presumed fibroid.

Smooth Muscle Tumor

Uterine Leiomyoma

Uterine Fibroids

10.47836/mjmhs.19.6.51

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