Elena Lobashevsky

University of Alabama

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i-10 index

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Richard A. Kaslow

Yale University

Jianming Tang

University of Alabama at Birmingham

M. Tevfik Dorak

Kingston University

Joseph Biggio

Ochsner Medical Center

Akila Subramaniam

University of Alabama at Birmingham

John Owen

European CanCer Organisation

Jeff M. Szychowski

University of Alabama at Birmingham

Wenshuo Shao

University of Alabama at Birmingham

Elliot J. Lefkowitz

University of Alabama at Birmingham

Casey D. Morrow

University of Alabama at Birmingham

Cooperative Institutions

University of Alabama at Birmingham

University of Alabama

Emory University

Johns Hopkins University

National Institutes of Health

University of California, San Francisco

University of Alabama at Birmingham Hospital

University of North Carolina at Chapel Hill

Alabama Department of Public Health

Centers for Disease Control and Prevention

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SPECIFICITY OF PREFORMED ALLOANTIBODIES CAUSING B CELL POSITIVE FLOW CROSSMATCH (FCXM) IN RENAL TRANSPLANTATION.

Transplantation (2000)

Andrew L. Lobashevsky Rhonda Senkbeil James Shoaf Cindy A. Mink Charyl Rowe

Lobashevsky, Andrew L.1; Senkbeil, Rhonda W.1; Shoaf, James l.1; Mink, Cindy A.1; Rowe, Charyl C.1; Lobashevsky, Elena S.1; Burke, Rebecca M.1; Hudson, Sharon1; Thomas, Judith M.1; Deierhoi, Mark H.1 Author Information

ROWE

10.1097/00007890-200004271-00270

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Citations (1)

408: Association of the cervicovaginal microbiome with cervical shortening in women with prior spontaneous preterm birth

American Journal of Obstetrics and Gynecology (2019)

Akila Subramaniam Boyi Guo Elena Lobashevsky William Van Der Pol Elliot J. Lefkowitz

Amplicon sequencing

Amplicon

10.1016/j.ajog.2019.11.424

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Cytokine and chemokine gene polymorphisms in North American populations either infected or at risk of infection with human immunodeficiency virus type 1 (HIV-1)

Human Immunology (2003)

Cheng-Bin Wang Wei Song Elena Lobashevsky Joannis Mytilineos Craig M. Wilson

10.1016/j.humimm.2003.08.329

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Midtrimester microbial DNA variations in maternal serum of women who experience spontaneous preterm birth

The Journal of Maternal-Fetal & Neonatal Medicine (2018)

Akila Subramaniam William J. Van Der Pol Travis Ptacek Elena Lobashevsky Cherry Neely

Objectives: To evaluate if midtrimester maternal serum contains microbial DNA and whether it differs between women with spontaneous preterm birth (SPTB) and those delivering at term.Study design: In this retrospective case–control study, we identified 20 healthy nulliparas with SPTB at 24–33 weeks of a nonanomalous singleton in 2014. Each case was matched by race/ethnicity to a control delivering at 39–40 weeks. Serum samples, collected at 15–20 weeks and stored at −80 C, were thawed and DNA extracted. PCR with primers targeting the 16S rDNA V4 region were used to prepare an amplicon library, sequenced using Illumina MiSeq, and analyzed using quantitative insight into microbial ecology (QIIME). Taxonomy was assigned using Ribosomal Database program (RDP) Classifier (threshold 0.8) against a modified Greengenes database. Differences in number of observed species, microbial alpha-diversity and beta-diversity, and taxa level analyses were undertaken.Results: All 40 samples were included. Women with SPTB had more unique observed species (p = .046) and higher mean alpha-diversity by Shannon index (but not Chao1 or Simpson) (p = .024). Microbial composition was different between groups by Bray–Curtis clustering (p = .03) but not by weighted (p = .13) or unweighted Unifrac (p = .11). Numerous taxa in the Firmicutes, Proteobacteria, and Actinobacteria phyla differed between groups (p < .05).Conclusions: SPTB is associated with distinct microbial DNA changes detected in midtrimester maternal serum.

10.1080/14767058.2018.1490721

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Specificity of preformed alloantibodies causing B cell positive flow crossmatch in renal transplantation

Clinical Transplantation (2000)

Andrew L. Lobashevsky Rhonda Senkbeil James Shoaf Cindy A. Mink Charyl Rowe

The specificity of alloantibodies (alloAb) and their clinical significance in association with T-/B+ flow cytometry crossmatch (FCXM) in kidney transplantation are not clearly defined. This study was undertaken to examine the HLA specificity and clinical relevance of Ab causing B+ FCXM in pre-transplant (final XM) recipients' serum samples. Final FCXM serum samples were analyzed from 457 renal transplant patients followed for 10 months post-transplantation. Two hundred and sixty patients had T-/B+ final FCXM. The control group included 197 recipients with T-/B- FCXM at time of transplantation. Class I/class II PRA and specificity of anti-HLA class I and class II Ab in final FCXM serum samples were analyzed by FlowPRA Class I Screening Test and FlowPRA Class II Screening Test. We found no correlation between graft outcome and pre-transplant T-/B- and T-/B+ FCXM status. Additionally, we observed no clinical relevance of B+ FCXM in retransplant patients. However, MCS > or =200 in B+ FCXM retransplant recipients was associated with anti-class II Ab to previous mismatches in regrafted patients (n = 46). This finding was confirmed by specificity analysis of anti-DR/DQ Ab in patients with high ( > or =15%) class II PRA. In 63% (12 of 19) of retransplants having T-/B+ FCXM, we defined the specificity of alloAb to first graft mismatched class II antigens. In contrast, anti-class II Ab was detected in only 5.7% (2 of 35) of single-graft recipients with different PRA values. Significantly greater MCS (240 +/- 61 vs. 163 +/- 48; p = 0.022) was observed in retransplant patients having short ( < or =5 m) previous graft survival time (PGST) than in those with long PGST ( > or =5 m). Only 2% of retransplant recipients with B + FCXM had non-HLA Ab. In contrast, the overwhelming majority of primary recipients had no detectable alloAbs. No significant difference in class I PRA was found between B- and B+ FCXM recipients. However, class II PRA was significantly higher in patients having B + FCXM (p = 0.028). Collectively, these data show that MCS intensity is not always a reliable criterion for anti-HLA Ab detection because of the presence of non-HLA Ab. These results can be explained by low titers of anti-class II Ab, at which concentration these Ab cannot produce a deleterious effect. FlowPRA and Flow screen beads appeared to be reliable and sensitive methods for detection and specificity analysis of anti-class II alloAb.

Clinical Significance

Isoantibodies

Histocompatibility Testing

Histocompatibility

10.1034/j.1399-0012.2000.140604.x

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Citations (47)

Host genetic profiles predict virological and immunological control of HIV-1 infection in adolescents

AIDS (2002)

Jianming Tang Craig M. Wilson Shreelatha Meleth Angela D. Myracle Elena Lobashevsky

Objective: To evaluate the correlation between host genetic profiles and virological and immunological outcomes among HIV-1-seropositive participants from the Reaching for Excellence in Adolescent Care and Health (REACH) cohort. Methods: HLA class I and chemokine coreceptor (CCR) alleles and haplotypes were resolved in 227 HIV-1-seropositive adolescents (ages 13–18 years; 75% females; 71% African-Americans) and 183 HIV-seronegative individuals, with quarterly follow-up visits between 1996 and 2000. Each HLA and CCR variant with consistent risk and protective effect on HIV-1 pathogenesis was assigned a score of −1 and +1, respectively. All individual markers and genetic scores were analyzed in relation to plasma viral load (VL) and CD4 T lymphocytes during a 6–12-month interval when no antiretroviral therapy was taken. Results: HLA-B*57 alone was a strong predictor of VL (P < 0.0001), but composite genetic profiles found in over 50% of patients consistently outperformed the individual component markers in multivariable analyses with or without adjustment for gender, race, age, and membership of clinical patient groups. Adolescents (n = 37) with a favorable combination of VL (< 1000 copies/ml) and CD4 T cell counts (> 450 × 106 cells/l) consistently had more positive (+1 to +2) than negative (−1 to −4) HLA and CCR scores compared with those (n = 56) with an unfavorable combination (VL > 16 000 copies/ml and CD4 cells < 450 × 106 cells/l) or the remainder (n = 134) of the cohort (overall P < 0.0001). Conclusion: A generalizable genetic scoring algorithm based on seven HLA class I and CCR markers is highly predictive of viremia and immunodeficiency in HIV-1-infected adolescents.

10.1097/00002030-200211220-00007

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Citations (63)

Linkage disequilibria between fully resolved MICA alleles and HLA variants in European Americans

Human Immunology (2004)

Elena Lobashevsky Wenshuo Shao Jianming Tang M. Tevfik Dorak Aleksandr Lazaryan

Linkage (software)

10.1016/j.humimm.2004.07.196

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The C282Y mutation of HFE is a risk factor for HIV-related Kaposi’s sarcoma

Human Immunology (2003)

M. Tevfik Dorak Wenshuo Shao Elena Lobashevsky Jianming Tang Richard A. Kaslow

10.1016/j.humimm.2003.08.273

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Citations (5)

Molecular characterization of the mongolian ancestral haplotype 58.1 (B∗5801-DRB1∗0301) and comparison with Caucasian and African DRB1∗0301 haplotypes

Human Immunology (2003)

Helmut K.G. Machulla Wenshuo Shao Elena Lobashevsky Dugernjam Batnasan M. Tevfik Dorak

Characterization

10.1016/j.humimm.2003.08.313

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Cytokine and Chemokine Gene Polymorphisms Among Ethnically Diverse North Americans With HIV-1 Infection

JAIDS Journal of Acquired Immune Deficiency Syndromes (2004)

Chengbin Wang Wei Song Elena Lobashevsky Craig M. Wilson Steven D. Douglas

Twenty-four common single nucleotide polymorphisms (SNPs) in 10 cytokine and chemokine genes were defined in 579 North Americans at high risk of HIV-1 infection due to sexual behavior and injection drug use. Among the 3 major ethnic (African-American, Hispanic/Latino, and other) groups involved, HIV-1–seropositive individuals differed significantly from ethnically matched HIV-1–seronegative individuals (odds ratios = 2.13–4.82; P = 0.003–0.05) for several SNPs and haplotypes defined at the IL4, IL4R, IL6, IL10, CCL5 (RANTES), and CXCL12 (SDF1) loci. In addition, the homozygous IL4–590T/T genotype was associated with higher (+87−131 cells/μL) CD4+ T-cell counts in HIV-1–infected and AIDS-free adolescents not receiving antiretroviral therapy (adjusted P = 0.004). No SNPs at IFNG, IL2, IL12B, TNF, or CCL2 (MCP1) showed any association with HIV-related outcomes. Additional typing for IL1A, IL1B, IL1R1, IL1RN, and TGFB1 SNPs also failed to demonstrate any influence on HIV-1 infection or virologic/immunologic control in more selected patient groups. Coupled with previous findings, our data suggest that heritable IL4 and IL10 variations may contribute to the acquisition or progression of HIV infection and that the effects of other targeted loci in the cytokine and chemokine system cannot be established unequivocally in the study populations.

CXCL9

CCL5

10.1097/00126334-200404150-00002

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Citations (42)