G Cuny

Centre de Coopération Internationale en Recherche Agronomique pour le Développement

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Co-Authors

R Herbeuval

Centre Hospitalier Régional et Universitaire de Nancy

Philippe Solano

Université de Montpellier

Stéphane Herder

Centre de Coopération Internationale en Recherche Agronomique pour le Développement

Vincent Jamonneau

Institut de Recherche pour le Développement

Sophie Ravel

Biologie et Génétique des Interactions Plante-Parasite

Gustave Simo

Université de Dschang

Pascal Grébaut

Institut de Recherche pour le Développement

Flobert Njiokou

Université de Yaoundé I

Dominique Cuisance

Centre de Coopération Internationale en Recherche Agronomique pour le Développement

C Jeandel

Hôpital Arnaud de Villeneuve

Cooperative Institutions

Institut de Recherche pour le Développement

124

Centre National de la Recherche Scientifique

120

Université de Montpellier

Inserm

Centre de Coopération Internationale en Recherche Agronomique pour le Développement

Agropolis International

Centre Hospitalier Régional et Universitaire de Nancy

Université Paris Cité

Centre de Médecine Préventive

Institut de Recherche pour le Développement

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Research Field

[Study of the alkaloid Rauwolfia serpentina in the treatment of hypertension].

PubMed (1954)

R Herbeuval G Cuny M Manciaux R Guidat

Apocynaceae

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Citations (1)

Genetic variability within Trypanosoma brucei gambiense: evidence for the circulation of different genotypes in human African trypanosomiasis patients in Côte d'Ivoire

Transactions of the Royal Society of Tropical Medicine and Hygiene (2002)

Philippe Truc Sophie Ravel Vincent Jamonneau P. N'Guessan G Cuny

For 23 Ivoirian patients infected by Trypanosoma brucei gambiense, isolation and genetic characterization using PCR and microsatellite primers were performed (in 1996–1999) using 2 different isolates (A and B) from each patient. When using TBDAC 1/2, 7 genotypes were observed, and DNAs A and B for 2 patients were different. This might be the first evidence of the presence of 2 different genotypes of T. b. gambiense group 1 in the same patient.

Cote d ivoire

Kinetoplastida

Isolation

10.1016/s0035-9203(02)90237-3

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Citations (29)

Monitoring the developmental status of Trypanosoma brucei gambiense in the tsetse fly by means of PCR analysis of anal and saliva drops

Acta Tropica (2003)

Sophie Ravel Pascal Grébaut Dominique Cuisance G Cuny

Tsetse fly

Glossina morsitans

10.1016/s0001-706x(03)00191-8

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Citations (35)

Short Communication: Multiply SplicedenvandnefTranscripts of Simian Immunodeficiency Virus from West African Green Monkey (SIVagm-sab)

AIDS Research and Human Retroviruses (1998)

Frédéric Bibollet‐Ruche G Cuny Xavier Pourrut Cécile Brengues Anh Galat‐Luong

We have characterized the spliced transcripts of nef and envelope genes of SIVagm from African green monkey of the sabaeus subspecies. Most of the transcripts we have studied, representing the most abundant mRNA species in our assay, have undergone a specific splicing event that removes a part of the trans-activation response (TAR) element. This region is predicted to form a stable secondary structure (four stem–loop elements in SIVagm-sab) that affects the trans-activation of viral gene expression by Tat and the translation of the viral transcripts. Contrary to what is observed in other viruses, in which this R-region splicing has also been described (e.g., HIV-2), the LTR splicing in SIVagm-sab removes part of the first stem–loop and the following ones, nearly completely disrupting the TAR element secondary structure. Because LTR splicing seems to be a conserved feature among the strains we have characterized, these results suggest that this phenomenon could have important consequences for virus replication, pathogenicity, and latency.

Simian immunodeficiency virus

African Green Monkey

Simian

10.1089/aid.1998.14.515

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Citations (1)

Improvement of blood and fly gut processing for PCR diagnosis of trypanosomosis

Parasite (1996)

Laurent Penchenier Valérie Dumas Pascal Grébaut Jean Marc Reifenberg G Cuny

We have adapted a simple and efficient technique to detect trypanosomes in human blood, without DNA purification, and increased the sensitivity threshold to 1 parasite in 1 ml. We have then applied it for detection of parasites in midguts of tsetse flies, negative by microscopy. This technique has been developed for field conditions and could greatly facilitate epidemiological studies.

Tsetse fly

10.1051/parasite/1996034387

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Citations (47)

[Study of the passage of hematopoietic cells in the circulating blood in cancer. Importance of megakaryocytemia].

PubMed (1962)

H Herbeuval R Herbeuval G Cuny J Duheille O Guerci

Blood cancer

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Citations (1)

The Trypanosoma brucei gambiense Secretome Impairs Lipopolysaccharide-Induced Maturation, Cytokine Production, and Allostimulatory Capacity of Dendritic Cells

Infection and Immunity (2013)

Edwin Garzón Philippe Holzmüller Rachel Bras‐Gonçalves Philippe Vincendeau G Cuny

Trypanosoma brucei gambiense, a parasitic protozoan belonging to kinetoplastids, is the main etiological agent of human African trypanosomiasis (HAT), or sleeping sickness. One major characteristic of this disease is the dysregulation of the host immune system. The present study demonstrates that the secretome (excreted-secreted proteins) of T. b. gambiense impairs the lipopolysaccharide (LPS)-induced maturation of murine dendritic cells (DCs). The upregulation of major histocompatibility complex class II, CD40, CD80, and CD86 molecules, as well as the secretion of cytokines such as tumor necrosis factor alpha, interleukin-10 (IL-10), and IL-6, which are normally released at high levels by LPS-stimulated DCs, is significantly reduced when these cells are cultured in the presence of the T. b. gambiense secretome. Moreover, the inhibition of DC maturation results in the loss of their allostimulatory capacity, leading to a dramatic decrease in Th1/Th2 cytokine production by cocultured lymphocytes. These results provide new insights into a novel efficient immunosuppressive mechanism directly involving the alteration of DC function which might be used by T. b. gambiense to interfere with the host immune responses in HAT and promote the infectious process.

CD86

CD80

10.1128/iai.00125-13

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Citations (16)

Characterization of Sleeping Sickness Transmission Sites in Rural and Periurban Areas of Kinshasa (République Démocratique du Congo)

Vector-Borne and Zoonotic Diseases (2009)

Pascal Grébaut Jean-Marie Bena Emile Z. Manzambi Philémon Mansinsa Victor Khande

To characterize the potential transmission sites of sleeping sickness in Kinshasa, two entomologic surveys were carried out during the dry and the rainy seasons in rural and periurban areas of Kinshasa in 2005. About 610 pyramidal traps were set up, and 897 Glossina fuscipes quanzensis were captured. Environmental and biologic factors were reported, and relationships between these factors were evaluated using logistic regression and multiple correspondence analysis. The biologic factors (the presence of tsetse flies, human blood meals, and teneral flies) were progressively accumulated at each capture site to permit the characterization of the sleeping sickness transmission risk. The dry season was found to be a more favorable period for the disease transmission than the rainy season. Moreover, the landscapes characterized by the presence of argillaceous soils, raised ground cover with forest residues and rivers, were identified as types of environments with greater risk of sleeping sickness transmission. Pig breeding appeared as an important factor increasing the disease transmission. If vector control is continuously performed along rivers segments at high risk, the transmission of sleeping sickness in rural and periurban areas of Kinshasa will considerably decrease.

Dry season

Wet season

Disease Transmission

10.1089/vbz.2008.0118

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Citations (14)

Microsatellite genotyping reveals diversity within populations of Sodalis glossinidius, the secondary symbiont of tsetse flies

Veterinary Microbiology (2011)

Oumarou Farikou Flobert Njiokou G Cuny Anne Geiger

Tsetse fly

Population Genetics

10.1016/j.vetmic.2011.01.021