Prashanth Panduranga

Royal Hospital

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Kadhim Sulaiman

Royal Hospital

Wael Almahmeed

Cleveland Clinic

Jassim Al Suwaidi

Hamad Medical Corporation

Khalid F. AlHabib

King Saud University

Ahmed Al‐Motarreb

Sana'a University

Nidal Asaad

Hamad Medical Corporation

Alawi Alsheikh‐Ali

Mohammed Bin Rashid University of Medicine and Health Sciences

Mohammed Al‐Jarallah

Al-Sabah Hospital

Ibrahim Al‐Zakwani

Sultan Qaboos University Hospital

Nooshin Bazargani

Dubai Hospital

Cooperative Institutions

Royal Hospital

113

Hamad Medical Corporation

King Saud University

Ministry of Health

King Faisal Specialist Hospital & Research Centre

Sultan Qaboos University

Weill Cornell Medical College in Qatar

Saud Al-babtain Cardiac Centre

Ministry of Agriculture and Fisheries

Sultan Qaboos University Hospital

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Development and Validation of R-hf Risk Score in Acute Heart Failure Patients in the Middle East

Oman Medical Journal (2023)

Rajesh Rajan Mohammed Al‐Jarallah Ibrahim Al‐Zakwani Raja Dashti Kadhim Sulaiman

The Rajan's heart failure (R-hf) score was proposed to aid risk stratification in heart failure patients. The aim of this study was to validate R-hf risk score in patients with acute decompensated heart failure.R-hf risk score is derived from the product estimated glomerular filtration rate (mL/min), left ventricular ejection fraction (%), and hemoglobin levels (g/dL) divided by N-terminal pro-brain natriuretic peptide (pg/mL). This was a multinational, multicenter, prospective registry of heart failure from seven countries in the Middle East. Univariable and multivariable logistic regression was applied.A total of 776 patients (mean age = 62.0±14.0 years, 62.4% males; mean left ventricular ejection fraction = 33.0±14.0%) were included. Of these, 459 (59.1%) presented with acute decompensated chronic heart failure. The R-hf risk score group (≤ 5) was marginally associated with a higher risk of all-cause cumulative mortality at three months (adjusted odds ratio (aOR) = 4.28; 95% CI: 0.90-20.30; p =0.067) and significantly at 12 months (aOR = 3.84; 95% CI: 1.23-12.00; p =0.021) when compared to those with the highest R score group (≥ 50).Lower R-hf risk scores are associated with increased risk of all-cause cumulative mortality at three and 12 months.

10.5001/omj.2023.89

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Rocking mitral annuloplasty ring : case report

Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa (2012)

Prashanth Panduranga Mohammed Mukhaini

Dehiscence of a mitral annuloplasty ring is a rare occurrence. We present a young patient with long-standing gross dehiscence of a Duran annuloplasty ring secondary to suture dehiscence, occurring three years after mitral valve surgery. It was detected by transthoracic echocardiography. This case emphasises the importance of clinical and echocardiographic follow-up examinations after mitral valve surgery to detect any unexpected complications.

Mitral valve annuloplasty

10.5830/cvja-2011-055

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PO180 Angiographic and Procedural Results of Percutaneous Coronary Intervention In Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction

Global Heart (2018)

Prashanth Panduranga Mohammad Sirajul Islam

10.1016/j.gheart.2018.09.158

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The Epidemiology of Acute Coronary Syndrome in Oman : Results from the Oman - RACE Study = وبائيات متلازمة الشريان التاجي الحادة في سلطنة عمان : نتائج دراسة عمان - ريس

Sultan Qaboos University medical journal (2013)

Jawad Al‐Lawati Kadhim Sulaiman Prashanth Panduranga

This study aimed to evaluate the epidemiology and coronary risk factors of acute coronary syndrome (ACS) in Oman.

Unstable angina

10.12816/0003194

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Citations (16)

Dynamic left ventricular outflow tract obstruction complicating aortic valve replacement: A hidden malefactor revisited

DOAJ (DOAJ: Directory of Open Access Journals) (2010)

Prashanth Panduranga Maddali Madan Mukhaini Mohammed Valliattu John

Ventricular outflow tract

Outflow

Source

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Percutaneous coronary intervention of a saphenous vein graft ostial stenosis in a patient with Bentall procedure

Journal of the Saudi Heart Association (2010)

Mohammed Mukhaini Prashanth Panduranga

Composite graft replacement of the aortic root and coronary reimplantation with or without coronary artery bypass surgery is the standard treatment for a variety of aortic root pathologies. Previously, percutaneous coronary intervention of either reimplanted coronary arteries or left/right coronary artery through cabrol graft has been described in post-Bentall patients. We describe percutaneous coronary intervention of a saphenous vein graft ostial stenosis in a patient with previous Bentall procedure and a vein graft to right coronary artery, which was complex and challenging.

Bentall procedure

Saphenous vein graft

Coronary arteries

10.1016/j.jsha.2010.06.001

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Impact of Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptors Blockers on Mortality in Acute Heart Failure Patients with Left Ventricular Systolic Dysfunction in the Middle East: Observations from the Gulf Acute Heart Failure Registry (Gulf CARE)

Current Vascular Pharmacology (2017)

Ibrahim Al‐Zakwani Kadhim Sulaiman Jawad Al‐Lawati Alawi Alsheikh‐Ali Prashanth Panduranga

To evaluate the impact of Angiotensin-Converting Enzyme Inhibitors (ACEIs)/ Angiotensin Receptors Blockers (ARBs) on in-hospital, 3- and 12-month all-cause mortality in Acute Heart Failure (AHF) patients with left ventricular systolic dysfunction in 7 countries of the Middle East.Data was analysed from 2,683 consecutive patients admitted with AHF and Left Ventricular Ejection Fraction (LVEF) (<40%) from 47 hospitals from February to November 2012. Analyses were evaluated using univariate and multivariate statistics. The overall mean age of the cohort was 58±15, 72% (n=1,937) were males, 62% (n=1,651) had coronary artery disease, 57% (n=1,539) were hypertensives and 47% (n=1,268) had diabetes. Overall cumulative mortality at inhospital, 3- and 12-month follow-up was 5.8% (n=155), 12.6% (n=338) and 20.4% (n=548), respectively. Adjusting for demographic and clinical characteristics as well as medication in a multivariate logistic regression model, ACEIs were associated with lower risk of in-hospital mortality (adjusted odds ratio (aOR), 0.48; 95% Confidence Interval (CI): 0.25 to 0.94; p=0.031). At 3-month follow-up, both ACEIs (aOR, 0.64; 95% CI: 0.43 to 0.95; p=0.025) and ARBs (aOR, 0.34; 95% CI: 0.18 to 0.62; p<0.001) were associated with lower risk of mortality. Additionally, at 12-month follow-up, those prescribed ACEIs (aOR, 0.71; 95% CI: 0.53 to 0.96; p=0.027) and ARBs (aOR, 0.47; 95% CI: 0.31 to 0.71; p<0.001) were still associated with lower risk of mortality.ACEIs and ARBs treatments were associated with lower mortality risk during admission and up to 12-month of follow-up in Middle East AHF patients with left ventricular systolic dysfunction.

10.2174/1570161115666170817164420

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Large aortic root pseudoaneurysm occurring late after aortic root repair and valve replacement for endocarditis

Heart India (2013)

Prashanth Panduranga

A 68-year-old male presented with Group B Streptococcus aortic valve (AV) endocarditis with aortic root abscess and refractory sepsis. An emergency cardiac surgery was performed with root abscess drainage, excision and debridement of necrotic tissue, reconstruction of annulus, and AV replacement. Fifteen months later he presented with a huge aortic root pseudoaneurysm (PA). This case illustrates late occurrence of aortic root PA following AV surgery for endocarditis.

Pseudoaneurysm

Cardiac skeleton

Debridement (dental)

Refractory (planetary science)

10.4103/2321-449x.122782

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Assessment of Right Ventricular Diastolic Function by Tissue Doppler Imaging in Patients with Acute Right Ventricular Myocardial Infarction

Echocardiography (2010)

Mohammed Mukhaini Prashanth Panduranga Said Abdulrehman Majid Zadjali

It is known that right ventricular systolic parameters as assessed by color tissue Doppler imaging (TDI) are abnormal in patients with inferior wall ST elevation myocardial infarction (IWMI) with right ventricular myocardial infarction (RVMI). This study was undertaken to determine right ventricular diastolic function as assessed by TDI in patients with acute RVMI.Thirty-five patients with first IWMI were studied and compared with 20 age-matched healthy controls, and categorized into those with (14 patients) and without (21 patients) RVMI based on standard ECG criteria. Peak systolic, peak early and late diastolic velocities (Sm, Em, and Am), Em/Am ratio along with time to Sm (ECG Q-Sm) and time to Em (ECG Q-Em) were acquired from the apical 4-chamber view at the lateral side of tricuspid annulus using TDI.Sm, Em, and Em/Am ratio was reduced significantly in patients with RVMI as compared with those without RVMI and healthy individuals (Sm [11.1 + or - 2.9] vs. [14 + or - 1.9] and [14.5 + or - 2.1] cm/sec, P < 0.01; Em [9.2 + or - 3.5] vs. [12.9 + or - 3] and [14.0 + or - 2.0] cm/sec, P < 0.01; Em/Am ratio 0.53 + or - 0.2 vs. 0.78 + or - 0.19 and 0.8 + or - 0.3 [P < 0.0001]). Among the intervals, there was significant prolongation of Q-Em (558 + or - 14.8 vs. 507 + or - 16.2 and 480 + or - 20 ms [P < 0.0001]) but Q-Sm and Am were not statistically different between the groups.Right ventricular TDI diastolic parameters are abnormal in patients with RVMI. The method of recording the velocities and time intervals are simple and can be used to assess right ventricular diastolic function in patients with RVMI. (Echocardiography 2010;27:539-543).

Doppler imaging

10.1111/j.1540-8175.2009.01084.x

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Incidence and impact of cardiorenal anaemia syndrome on all‐cause mortality in acute heart failure patients stratified by left ventricular ejection fraction in the Middle East

ESC Heart Failure (2018)

Mohammed Al‐Jarallah Rajesh Rajan Ibrahim Al‐Zakwani Raja Dashti Bassam Bulbanat

Abstract Aims This study aims to evaluate the incidence and impact of cardiorenal anaemia syndrome (CRAS) on all‐cause mortality in acute heart failure (AHF) patients stratified by left ventricular ejection fraction (LVEF) status in the Middle East. Methods and results Data were analysed from 4934 consecutive patients admitted to 47 hospitals in seven Middle Eastern countries (Saudi Arabia, Oman, Yemen, Kuwait, United Arab Emirates, Qatar, and Bahrain) with AHF from February to November 2012. CRAS was defined as AHF with estimated glomerular filtration rate of <60 mL/min and low haemoglobin (<13 g/dL for men or <12 g/dL for women). Analyses were performed using univariate and multivariate statistical techniques. The overall mean age of the cohort was 59 ± 15 years, 62% ( n = 3081) were men, and 27% ( n = 1319) had CRAS. Co‐morbid conditions were common including hypertension ( n = 3014; 61%), coronary artery disease ( n = 2971; 60%), and diabetes mellitus ( n = 2449; 50%). A total of 79% ( n = 3576) of the patients had AHF with reduced ejection fraction (HF r EF) (LVEF < 50%). CRAS patients were associated with major bleeding (1.29% vs. 0.6%; P = 0.017), blood transfusion (10.1% vs. 3.0%; P < 0.001), higher re‐admission rate for AHF at 3 months' follow‐up (27.6% vs. 18.8%; P < 0.001) and at 12 months' follow‐up (34.3% vs. 26.2%; P < 0.001). Multivariate logistic regression demonstrated that patients with CRAS were associated with higher odds of all‐cause mortality during hospital admission [adjusted odds ratio (aOR), 2.10; 95% confidence interval (CI): 1.34–3.31; P = 0.001], at 3 months' follow‐up (aOR, 1.48; 95% CI: 1.07–2.06; P = 0.018), and at 12 months' follow‐up (aOR, 1.45; 95% CI: 1.12–1.87; P = 0.004). Stratified analyses showed that CRAS patients with HF r EF were associated with higher odds of all‐cause mortality during hospital admission (aOR, 2.03; 95% CI: 1.20–3.45; P = 0.009) and at 12 months' follow‐up (aOR, 1.42; 95% CI: 1.06–1.89; P = 0.019) but not at 3 months' follow‐up (aOR, 1.43; 95% CI: 0.98–2.09; P = 0.063). However, in AHF patients with preserved ejection fraction (LVEF ≥ 50%), CRAS was not associated with higher odds of all‐cause mortality not only during hospital admission (aOR, 2.15; 95% CI: 0.84–5.55; P = 0.113) but also at 3 months' follow‐up (aOR, 1.87; 95% CI: 0.93–3.76; P = 0.078) and at 12 months' follow‐up (aOR, 1.59; 95% CI: 0.91–2.76; P = 0.101). Conclusions The incidence of CRAS was 27%. CRAS was associated with higher odds of all‐cause mortality in AHF patients in the Middle East, especially in those with HF r EF.

Univariate analysis

10.1002/ehf2.12351

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Citations (31)