I. V. Leontyeva

Pirogov Russian National Research Medical University

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ДИ

Д. И. Садыкова

Rostov State University of Economics

ЕС

Е. С. Сластникова

Kazan State Medical University

ЛФ

Л. Ф. Галимова

Kazan State Medical University

ЛА

Л. А. Балыкова

National Research Mordovia State University

E. P. Kalachanova

Pirogov Russian National Research Medical University

ИА

И. А. Ковалев

Ministry of Health

Andrey V. Susekov

Russian Medical Academy of Continuous Professional Education

ЕА

Е. А. Николаева

Pirogov Russian National Research Medical University

АА

А А Александров

National Research Center for Preventive Medicine

ВБ

В. Б. Розанов

National Research Center for Preventive Medicine

Cooperative Institutions

Ministry of Health of the Russian Federation

Pirogov Russian National Research Medical University

Sechenov University

National Medical Research Center of Cardiology

Russian Academy of Sciences

National Research Center for Preventive Medicine

Russian Scientific Center of Surgery

Russian Medical Academy of Continuous Professional Education

Kazan State Medical University

Institute of Experimental Cardiology

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PROGNOSIS FOR HYPERTROPHIC CARDIOMYOPATHY IN CHILDREN

PEDIATRIA Journal named after G N SPERANSKY (2020)

I. V. Leontyeva И. А. Ковалев

10.24110/0031-403x-2020-99-3-235-244

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Citations (3)

Current Approaches to Arterial Hypertension Management in Children and Adolescents: Clinical Guidelines Review

Вопросы современной педиатрии (2021)

Л. А. Балыкова I. V. Leontyeva A. V. Krasnopolskaya Д. И. Садыкова Lilia S. Mashkina

The prevalence of arterial hypertension (AH) in children and adolescents is increasing, thus it is crucial and topical to make pediatricians familiar with modern approaches in drug and drug-free therapy for AH. The aim of this review was to provide the overview of international and Russian guidelines for the AH treatment. We have searched the following keywords in PubMed: guidelines, arterial hypertension treatment, guidelines of management, pediatric hypertension. Reviews, clinical guidelines, and original articles published from 2010 to 2020 were analyzed. Detailed description of AH management in children and adolescents is presented. Approaches to drug-free correction of increased blood pressure (BP) are discussed in detail, indications for antihypertensive therapy are described, characteristics of the main classes of antihypertensive drugs are given (indications, contraindications, and possible side effects). Principles of refractory AH management and antihypertensive drugs combinations are also described.

Antihypertensive drug

Refractory (planetary science)

Pharmacotherapy

10.15690/vsp.v20i4.2281

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Citations (1)

Cardiovascular system damage in the late-onset Pompe disease

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) (2023)

I. V. Leontyeva Yu. S. Isaeva И. М. Миклашевич S. A. Thermosesov

The article presents a clinical case of metabolic hypertrophic cardiomyopathy against the background of a late-onset form of Pompe disease, illustrating the difficulties of differential diagnostic search for the cause of the disease. The clinical, laboratory and genetic aspects of the diagnosis of Pompe disease are highlighted. The features of laboratory diagnostics, the difficult path to the correct diagnosis and the appointment of enzyme replacement therapy are discussed. Much attention is paid to the clinical symptoms of the disease — the most significant damage to the cardiovascular system, there is no damage to the musculoskeletal sphere. Clinical picture of late Pompe disease is presented: cardiac rhythm and conduction disorders (ventricular preexcitation syndrome — multiple additional atrioventricular fenestrations), unstable ventricular tachycardia, supraventricular tachycardia, sinus node weakness syndrome. Considered approaches to the prevention of sudden cardiac death the patient underwent surgical treatment: radiofrequency ablation, endocardial implantation of a cardioverter defibrillator. Pathogenetic therapy for Pompe disease has been started.

Supraventricular Tachycardia

Atrioventricular node

Sudden Death

10.21508/1027-4065-2023-68-3-83-91

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Eurasian clinical guidelines for the prevention of cardiovascular diseases in childhood and adolescence (2023)

Eurasian heart journal (2023)

O. A. Kislyak I. V. Leontyeva А. В. Стародубова A. A. Alersandrov М. Г. Бубнова

The EAC Guidelines represent the views of the EAC, and were produced after careful consideration of the scientific and medical knowledge, and the evidence available at the time of their publication.

Scientific evidence

10.38109/2225-1685-2023-3-6-35

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The relationship of bone mineral density with the of the intima-media thickness in premenopausal women

Osteoporosis and Bone Diseases (2021)

Е. N. Dudinskaya О. Н. Ткачева L. V. Matchekhina K. A. Eruslanova И. А. Ковалев

Background: Osteoporosis and cardiovascular disease (CVD) are among the most common causes of morbidity, disability and death worldwide. In recent years, more and more data have been accumulating on the presence of an age-independent relationship and general pathogenetic mechanisms of a decrease in bone mineral density (BMD) and the development of CVD. It has been shown that a decrease in BMD is an important independent predictor of the risk of atherosclerosis of the great arteries and is associated with increased calcification of the aorta and other vessels. The strongest relationship between these parameters was observed in the study of the female population, in connection with which we selected a group of middle-aged women for analysis. Objective: to investigate the association between bone mineral density and carotid intima-media thickness in middle-aged women. Results: 35 women were included in the study. The mean age was 44,74±4,32 years. We found the following changes in arterial wall characteristics: atherosclerosis — 21,9% women, increased carotid intima thickness — 15,7% women. Low bone mineral density for chronological age (Z-criteria -2,0 and less) was found in 7 patients at the age of 35±2,7 years. We discovered a negative correlation between the markers of subclinical atherosclerosis and bone mass: Ccarotid intimamedia thickness negatively correlated with bone mineral density in hip (p<0,05), and presence of atherosclerosis plaques was associated with lower bone mineral density in the proximal part of hip (p<0,05). Conclusion: The findings about negative association between bone mineral density of hip with preclinical markers of atherosclerosis allow us to make a conclusion about their interaction.

Subclinical infection

Intima-media thickness

10.14341/osteo12698

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MYOCARDITIS WITH OUTCOME IN DILATED CARDIOMYOPATHY COMPLICATED BY REFRACTORY HEART FAILURE AND REQUIRING HEART TRANSPLANTATION

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) (2018)

Л. А. Балыкова I. V. Leontyeva N. N. Urzyaeva N. V. Schekina Yu. A. Petrushkina

The article describes the clinical case of subacute myocarditis in a child with an outcome in dilated cardiomyopathy, complicated with congestive heart failure. Difficulties in diagnosing the disease that manifested with cardiac arrhythmia are discussed. The main signs suggesting postmiocardic cardiomyopathy included a reduced deflection voltage and frequent ventricular extrasystoles with episodes of the ventricular tachycardia in the onset of the disease, left ventricular dilatation, a significant decrease in ejection fraction, increased activity of natriuretic peptide, findings of perfusion scintigraphy and magnetic resonance imaging. Medical therapy and implantation of a cardioverter defibrillator were ineffective. The child repeatedly suffered from syncopal conditions with circulatory arrest, which required resuscitation. Due to the ineffectiveness of drug therapy conducted in the leading federal centres, considering cardiac transplantation abroad was recommended.

Dilated Cardiomyopathy

10.21508/1027-4065-2018-63-3-105-111

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Myocarditis in children. Modern aspects of diagnostics

Russian Pediatric Journal (2024)

Е. С. Васичкина Л. А. Балыкова Е. Н. Басаргина L.V. Bregel E. A. Degtyareva

Introduction. A review of the current literature on the features of the diagnosis of myocarditis in children is presented. Myocarditis is an acute or chronic inflammatory myocardial disease characterized by a variety of clinical manifestations, nonspecific symptoms and physical data. With insufficient number of informative diagnostic tests, there is a challenge for practitioners at all stages of medical care. Aim of the review is to comprehensively present the features of the clinical diagnosis of myocarditis in children. The presence of myocarditis should be assumed in situations where children, regardless of the age, first developed symptoms of heart failure (HF), as well as in the presence of a clinic of viral infections accompanied by respiratory or abdominal symptoms, combined with the development of tachycardia, hypotension or cardiac arrhythmias, even in the absence of cardiomegaly. Myocarditis should be clinically suspected at the stage when the necessary decisions should be made about the patient’s routing, the formation of a complex of diagnostic examinations and the start of therapy. Magnetic resonance imaging (MRI) of the heart is today the non-invasive gold standard for the diagnosis of myocarditis that allows detecting myocarditis within 2–3 weeks after the first symptoms appear. Endomyocardial biopsy can be used for accurate morphological diagnosis of myocarditis in children. Molecular biological and genetic studies that determine the severity and outcome of the disease are important for the diagnosis of myocarditis in children. Conclusion. Based on the literature data and own experience in diagnosing myocarditis, the authors have developed an original diagnostic algorithm to make the right medical decision in case of suspected acute myocarditis in children.

10.46563/1560-9561-2024-27-5-385-393

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Overweight adolescents with arterial hypertension: results of a 5-year prospective follow-up

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) (2010)

И В Трушкина И. В. Плотникова В О Чурилова I. V. Leontyeva Г. П. Филиппов

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Mitochondrial cardiomyopathies

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) (2016)

I. V. Leontyeva Е. А. Николаева

The paper considers the problem of diagnosing the heterogeneous forms of mitochondrial cardiomyopathies associated with impaired oxidative phosphorylation and decreased activity of the mitochondrial electron transport system due to mutations in mitochondrial or nuclear DNA genes. It is emphasized that mitochondrial cardiomyopathies rarely present as an isolated myocardial lesion and more frequently serve as a manifestation of multisystem disease. The paper provides the characteristics of cardiomyopathies in some mitochondrial syndromes and shows the possibilities of treating this disease.

Mitochondrial disease

Human mitochondrial genetics

10.21508/1027-4065-2016-61-3-22-30

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Citations (7)

MODERN APPROACHES TO THE TREATMENT OF HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA

Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) (2017)

I. V. Leontyeva

Familial hypercholesterolemia remains a little-known disease in pediatric clinical practice, leading to late diagnosis and late initiation of therapy for this prognostically extremely unfavorable disease. The article presents modern ideas about etiology, genetic aspects. The diagnostic criteria and modern approaches to treatment are presented. The main clinical manifestations of the disease are cutaneous and tendon xanthomas, arcus lipoides of the cornea, generalized atherosclerosis of the coronary, brachiocephalic and femoral arteries. The consequence of these changes is the occurrence already in childhood of coronary heart disease and myocardial infarction. Effective lipid-lowering therapy was demonstrated in a child with homozygous hypercholesterolemia (2 mutations in the compound homozygous state in the LDLR gene). At the first stage, the child received combined therapy with statins (rosuvastatin in combination with ezetrol). The connection of the third drug, a type 9 inhibitor of proproteinconvertase, reduced the level of low-density lipoprotein cholesterol by another 15%, which was accompanied by regression of xanthomas. No adverse effects of therapy were observed.

Etiology

Xanthoma

10.21508/1027-4065-2017-62-4-71-80

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Citations (2)