Sadaaki Komura

Institute of Applied Biochemistry

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Effects of interferon-beta in combination with 5-fluorouracil on the growth of esophageal cancer cells in vitro.

PubMed (2002)

H Tsunoo Sadaaki Komura Nobuko Ohishi S Akiyama Yuichi Kasai

The possible antiproliferative potency of human recombinant interferon-beta (hIFN-beta) towards ten human esophageal cancer cell lines was examined in comparison with the activity of the factor towards human malignant melanoma cell lines. The cell growth of esophageal cancer cell lines was inhibited by hIFN-beta in a dose- and time- dependent manner. The 50% inhibitory concentrations (IC50) of hIFN-beta on nine cell lines out of ten ranged between 23 to 332 IU/ml of culture medium. The remaining cell line, T.Tn, was less sensitive to the interferon (IC50, 611 IU/ml). Under the same culture conditions, the melanoma cell lines tested differed markedly in their sensitivity to hIFN-beta. When the esophageal cancer cells were treated with 5-fluorouracil (5-FU) in the presence of a low concentration of hIFN-beta, the effectiveness of 5-FU was markedly enhanced. In particular, the rate of growth inhibition of T.Tn cells was more than the added potencies of 5-FU and hIFN-beta indicating that the interferon is an effective biomodulator of 5-FU. All these data suggest that combination therapy with hIFN-beta and the anticancer drug 5-FU would be beneficial for the treatment of carcinoma of the esophagus.

Growth inhibition

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Citations (3)

Protective Effect of Catecholestrogen on Injury Caused by 60Co-Irradiation in Mice.

Journal of Clinical Biochemistry and Nutrition (1995)

Akira Tomatsu Masami Nakanishi Masahiro Sakanaka Sadaaki Komura Nobuko Ohishi

When 10-week-old male BALB/c mice received whole-body irradiation with a sublethal 4-Gy single dose of 60Co γ-ray, the occurrence of leucopenia caused by the irradiation was lessened to some extent by subcutaneous injection of 2-hydroxyestradiol (2-OHE2), one of catecholestrogens, given 3h before and 3h after the irradiation. Upon irradiation, the weight of the thymus was reduced, but the recovery of organ weight was markedly accelerated by subcutaneous injection of 2-OHE2. Light microscopic observation revealed that 2-OHE2 prevents the reduction by γ-ray irradiation of cortical and medullary volumes of the thymus. These results indicate that 2-OHE2 is a potent radioprotector.

Subcutaneous injection

Whole body irradiation

Radiobiology

10.3164/jcbn.18.49

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Citations (3)

523 Effect of catecholestrogens on survival rate, lipid peroxide levels, and hematopoietic function of mice after ^ Co γ-irradiation.

日本産科婦人科學會雜誌 (1990)

Akira Tomatsu Yosuke Nakagawa Moyuru Suzuki M. Noguchi Miki Nakanishi

Peroxide

Lipid peroxide

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Citations (0)

Partial Purification and Properties of L-2, 4-Diaminobutyric Acid Activating Enzyme from a Polymyxin E Producing Organism1

The Journal of Biochemistry (1979)

Sadaaki Komura Kiyoshi Kurahashi

Journal Article Partial Purification and Properties of L-2, 4-Diaminobutyric Acid Activating Enzyme from a Polymyxin E Producing Organism Get access Sadaaki KOMURA, Sadaaki KOMURA Institute for Protein Research, Osaka University, Yamada-kamiSuita, Osaka 565 Search for other works by this author on: Oxford Academic PubMed Google Scholar Kiyoshi KURAHASHI Kiyoshi KURAHASHI Institute for Protein Research, Osaka University, Yamada-kamiSuita, Osaka 565 Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Biochemistry, Volume 86, Issue 4, October 1979, Pages 1013–1021, https://doi.org/10.1093/oxfordjournals.jbchem.a132594 Published: 01 October 1979 Article history Received: 06 April 1979 Published: 01 October 1979

10.1093/oxfordjournals.jbchem.a132594

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Citations (26)

ChemInform Abstract: Isolation of Antioxidative Compounds from Brazilian Propolis: 3,4‐Dihydroxy‐5‐prenylcinnamic Acid, a Novel Potent Antioxidant.

ChemInform (2000)

Katsuhiro Hayashi Sadaaki Komura Noriko Isaji Nobuko Ohishi Kunio Yagi

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Propolis

Isolation

10.1002/chin.200016247

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Citations (0)

Induction of lipid peroxidation in rat liver microsomes by catecholamine-iron complex.

Journal of Clinical Biochemistry and Nutrition (1990)

Kunio Yagi Naoko Ishida Sadaaki Komura Nobuko Ohishi

Epinephrine and norepinephrine, when either formed a complex with iron, were able to induce lipid peroxidation in rat liver microsomes. The microsomal lipid peroxidation induced by them was NADPH-dependent. Adrenochrome, an oxidation product of epinephrine, was also able to induce microsomal lipid peroxidation in the presence of iron, but in this case it was mainly NADPH-independent. Catecholamines can be deleterious to biological systems, if they form complexes with iron and thus induce lipid peroxidation to some extent.

Adrenochrome

Microsoma

10.3164/jcbn.9.179

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Citations (8)

Remarkable decrease in d-amino acid oxidase activity in the kidney of both prone and resistant strains of senescence-accelerated mouse

Journal of Molecular Catalysis B Enzymatic (2001)

Shin-ichiro Yokoyama Nobuko Ohishi Miyuki Nagai Sadaaki Komura Masanori Hosokawa

Senescence

D-amino acid oxidase

Southern blot

10.1016/s1381-1177(00)00211-3

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Citations (0)

Serum lipid peroxide levels in rats with inherited cataracts.

PubMed (1985)

Keiko Yagi Sadaaki Komura Nobuo Ihara Abe H Hiroyoshi Konishi

In a new strain of rat with inherited cataracts, a postnatal increase in serum lipid peroxide level was observed. It reached the maximum on the 13th day after birth. This seems to be a reflection of the increased lipid peroxides in the liver. In accordance with the increase in serum lipid peroxide level, the occurrence of vacuoles in the subcapsular fibers of the posterior region of the lens was observed by electron microscopy, suggesting a relationship between the increase in serum lipid peroxides and the provocation of cataract formation.

Lipid peroxide

Peroxide

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Citations (35)

Biosynthesis of Antibiotic Peptides Polymyxin E and Gramicidin A

De Gruyter eBooks (1982)

Kiyoshi Kurahashi Sadaaki Komura Katsuhiko Akashi Chika Nishio

Polymyxin

Gramicidin S

Polymyxin B

10.1515/9783110837834-026