No AccessJournal of UrologyClinical Urology: Original Articles1 Apr 1999THE RELATIVE AMOUNT OF EPITHELIUM, MUSCLE, CONNECTIVE TISSUE AND LUMEN IN PROSTATIC HYPERPLASIA AS A FUNCTION OF THE MASS OF TISSUE RESECTED GEORGE A. SCHUSTER and TIMOTHY G. SCHUSTER GEORGE A. SCHUSTERGEORGE A. SCHUSTER More articles by this author and TIMOTHY G. SCHUSTERTIMOTHY G. SCHUSTER More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)61620-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The relative amounts of epithelium, connective tissue, muscle and gland lumen in benign prostatic hyperplasia have been reported but they have not been correlated with prostate size. We determine if the relative amount of prostatic tissue varies with prostate size. Materials and Methods: Paraffin blocks of transurethrally resected prostate tissue were randomly chosen from the archives of 58 patients with benign prostatic hyperplasia. Two new slides per patient were made and stained with prostate specific antigen or Masson trichrome, respectively. A total of 20 images from each slide were captured using a high resolution camera, digitized and analyzed with computer software for the relative percentage of the various tissue components. Results: As the amount of prostate tissue resected increased from less than 10 to greater than 70 gm. the epithelium had a 4-fold increase from 5.37 to 21.92%, the muscle component had a 42% decrease from 28.46 to 16.62%, the lumen doubled from 7.05 to 14.01% and the connective tissue remained relatively unchanged from 35.58 to 31.53%. There was a statistically significant difference in all components of prostatic tissue except for connective tissue when comparing prostates less than 30 versus greater than 30 gm., including epithelium 6.52 versus 16.10% (p <0.01), muscle 28.45 versus 20.78% (p <0.01), lumen 7.42 versus 14.58% (p <0.01) and connective tissue 35.74 versus 32.45% (p <0.06). The stroma-to-epithelium and muscle-to-epithelium ratios each had a 9-fold decline (p = 0.01). Conclusions: As the prostate increases in size, there is statistically significant more epithelium and lumen, and less muscle tissue. References 1 : Benign nodular hyperplasia of the prostate: a review. Ann. Roy. Coll. Engl.1954; 14: 92. Google Scholar 2 : Evolving patterns of tissue composition in benign prostatic hyperplasia as a function of specimen size. Hum. Path.1990; 21: 578. Google Scholar 3 : Origin and evolution of benign prostatic enlargement. Invest. Urol.1978; 15: 340. Google Scholar 4 : The molecular biology, endocrinology, and physiology of the prostate and seminal vesicles. In: . Philadelphia: W. B. Saunders, Co.1992: 221. chapt. 6. Google Scholar 5 : Benign prostatic hyperplasia. In: . Philadelphia: W. B. Saunders, Co.1992: 1007. chapt. 25. Google Scholar 6 : The relative proportion of stromal and epithelial hyperplasia is related to the development of symptomatic benign prostate hyperplasia. J. Urol.1992; 147: 1293. Link, Google Scholar 7 : Purification of human prostate specific antigen. Invest. Urol.1979; 17: 159. Google Scholar 8 : A rapid one-step trichrome stain. Amer. J. Clin. Path.1950; 20: 661. Google Scholar 9 : Weight loss of prostatic tissue during electroresection. Scand. J. Urol. Nephrol.1975; 9: 214. Google Scholar 10 : The effects of epidural anesthesia on the urethral closure pressure profile in patients with prostatic enlargement. J. Urol.1980; 124: 410. Link, Google Scholar 11 : Light microscopic stereological analysis of the normal human prostate and of benign prostatic hyperplasia. J. Urol.1979; 122: 487. Link, Google Scholar 12 : Quantifying the smooth muscle content of the prostate using double-immunoenzymatic staining and color assisted image analysis. J. Urol.1992; 147: 1167. Link, Google Scholar 13 : Morphometry of the prostate: I. Distribution of tissue components in hyperplastic glands. Urology1994; 44: 486. Google Scholar From the St. Joseph Medical Center, Joliet and Loyola University, Chicago Stritch School of Medicine, Maywood, IllinoisSupported by grants from Merck & Co., Inc., West Point, Pennsylvania, and Provena-St. Joseph Medical Center Foundation, Joliet, Illinois.(Schuster) Financial interest and/or other relationship with Merck, Abbott and Pfizer.© 1999 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 161Issue 4April 1999Page: 1168-1173 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.MetricsAuthor Information GEORGE A. SCHUSTER More articles by this author TIMOTHY G. SCHUSTER More articles by this author Expand All Advertisement PDF downloadLoading ...
