The main drugs used for asthma include β2- adrenoceptor agonists,corticosteroids and leukotriene modifiers. Clinical and experimental studies found that there are individual differences in patient' s response to asthma drugs. The individual differences is associated with asthma- related genes,while some mutant gene loci can affect the patient's response to drug. These genes include β2- adrenergic receptor gene( ADRB2),the glucocorticoid receptor gene( NR3C1),leukotriene synthase( LTC4 S and ALOX5) genes and so on. The article will summarize asthma- related pharmacogenomics research,hoping to provide help for the future realization of personalized medicine for asthma.
