Smita S. Patel

Rutgers, The State University of New Jersey

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Manjula Pandey

Rutgers, The State University of New Jersey

Stanley B. Prusiner

University of California, San Francisco

Jiayu Shen

Johnson University

Stephen B. Freedman

Alberta Children's Hospital

Kerry L. Chapman

Sheffield Teaching Hospitals NHS Foundation Trust

Taekjip Ha

Howard Hughes Medical Institute

Brian S. Meldrum

King's College London

Urmimala Basu

Rutgers, The State University of New Jersey

Michelle D. Wang

Cornell University

Mikhail K. Levin

Bank of America

Cooperative Institutions

Merck & Co., Inc., Rahway, NJ, USA (United States)

109

Rutgers, The State University of New Jersey

103

MSD (UK) Limited (United Kingdom)

University of California, San Francisco

Johnson University

United States Military Academy

Harvard University

Institute for Neurodegenerative Disorders

Howard Hughes Medical Institute

Cornell University

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Branch migration enzyme as a Brownian ratchet

The EMBO Journal (2008)

Ivan Rasnik Yong-Joo Jeong Sean McKinney Vaishnavi Rajagopal Smita S. Patel

Atlanta

10.1038/emboj.2008.106

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Citations (30)

Red cell phenotyping using hexadimethrine bromide (Polybrene) in a microplate system

Transfusion (1984)

HJ Anderson Smita S. Patel

To provide rapidly phenotyped units of blood, we adapted the hexadimethrine bromide (Polybrene) technique to microplate technology. Pilot samples from 282 donor units were phenotyped for antigens in the Rh, Kidd, Kell, Duffy, and Ss systems with a standard tube‐testing method and a Polybrene‐microplate (P‐MP) technique. Diluted antisera and a 1 percent red cell suspension were used to give P‐MP reactions that were accurate and easy to interpret. One microplate, containing 96 tests, was prepared and read within 15 minutes for P‐MP tests yielding direct agglutination (Rh, Jkb, Fya, Fyb), or within 19 minutes for P‐MP tests requiring an antiglobulin phase (Jka, K, S, s). No false‐positive results were found. No false‐negative reactions were found in typing for Rh, K, S, s, or Jka antigens. Phenotyping for Jkb and Duffy antigens gave a false‐negative rate of less than 0.015. Considerable savings in reagents were obtained through microplate miniaturization and through the enhancement of apparent antibody avidity in the Polybrene/low ionic medium which permitted dilution of reagent antisera. The P‐MP technique affords a rapid, accurate, simple, and inexpensive means of phenotyping large numbers of donor units.

10.1046/j.1537-2995.1984.24484275581.x

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Citations (9)

Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

Proceedings of the National Academy of Sciences (2016)

Swapnil C. Devarkar Chen Wang Matthew T. Miller Anand Ramanathan Fuguo Jiang

Significance The cytosolic innate immune receptor Retinoic Acid Inducible Gene-I (RIG-I) is the principal detector of pathogenic RNAs carrying a 5′-triphosphate (5′ppp). Self RNAs like mRNAs evade recognition by RIG-I due to posttranscriptional modifications like 5′-end capping with 7-methyl guanosine (m7G) and 2′-O-methylation of 5′-end nucleotides. Viruses have also evolved mechanisms to mimic these modifications, which in part is believed to aid in immune evasion. Currently, it is unclear how these modifications modulate RIG-I recognition. This paper provides structural and mechanistic insights into the roles of the m7G cap and 2′-O-methylation in RIG-I evasion. We show that RIG-I accommodates the m7G base while maintaining the 5′ppp contacts and can recognize Cap-0 RNAs but not Cap-1.

RIG-I

RNA Helicase A

10.1073/pnas.1515152113

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Citations (308)

ChemInform Abstract: 2‐Aryltryptamines: Selective High‐Affinity Antagonists for the h5‐HT_2A Receptor.

ChemInform (2001)

Graeme I. Stevenson Adrian L. Smith Stephen J. Lewis Stephen G. Michie Joseph G. Neduvelil

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.200111111

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Fluorescence mapping of the open complex of yeast mitochondrial RNA polymerase.

Journal of Biological Chemistry (2009)

Guo-Qing Tang Swaroopa Paratkar Smita S. Patel

VOLUME 284 (2009) PAGES 5514–5522 On page 5517, the 2AP fluorescence value for the −3NT single-stranded DNA was not correct in Fig. 3B. The corrected Fig. 3B is shown below.

10.1074/jbc.a807880200

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ChemInform Abstract: 3-(4-Piperidinyl)- and 3-(8-Aza-bicyclo[3.2.1]oct-3-yl)-2-phenyl-1H-indoles as Bioavailable h5-HT2A Antagonists.

ChemInform (2001)

James Crawforth Simon Goodacre Robert Maxey Sylvie Bourrain Smita S. Patel

10.1002/chin.200111112

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The Protease Domain Increases the Translocation Stepping Efficiency of the Hepatitis C Virus NS3-4A Helicase

Journal of Biological Chemistry (2010)

Vaishnavi Rajagopal Madhura M. Gurjar Mikhail K. Levin Smita S. Patel

NS3

RNA Helicase A

Processivity

10.1074/jbc.m110.114785

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Citations (40)

Cryo-EM structure of yeast mitochondrial RNA polymerase partially-melted transcription initiation complex (PmIC)

Kalyan Kumar Das Smita S. Patel

Transcription

RNA polymerase II

10.2210/pdb6ymv/pdb

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2-Amino-7-phosphonoheptanoic acid (2-APH) infusion into entopeduncular nucleus protects against limbic seizures in rats

Neuroscience Letters (1986)

Smita S. Patel M.H. Millan Luiz E. Mello B.S. Meldrum

Muscimol

Pilocarpine

10.1016/0304-3940(86)90105-9

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Citations (62)

Lipid trajectories improve risk models for Alzheimer's disease and mild cognitive impairment

medRxiv (Cold Spring Harbor Laboratory) (2024)

Bruce A. Chase Roberta Frigerio Chad J. Yucus Smita S. Patel Demetrius M. Maraganore

Abstract To assess the relationship between lipids and cognitive dysfunction, we retrospectively analyzed blood-lipid levels in clinically well-characterized individuals with stable mild cognitive impairment (MCI) or Alzheimer’s disease (AD) over the decade prior to first cognitive symptoms. In this case/control cohort study, AD and MCI cases were diagnosed using DSM-IV criteria; MCI cases had not progressed to dementia for ≥5 years; and controls were propensity matched to cases at age of symptom onset (MCI: 116 cases, 435 controls; AD: 215 cases, 483 controls). Participants were grouped based on longitudinal trajectories and quintile of variability independent of the mean (VIM) for total cholesterol, HDL-C, LDL-C, non-HDL-C and ln(triglycerides). Models for the risk of cognitive dysfunction evaluated trajectory and VIM groups, APOE genotype, polygenic risk scores (PRS) for AD and lipid levels, age, comorbidities, and longitudinal correlates of blood-lipid concentrations. Lower HDL-C trajectories (OR = 3.8, 95% CI = 1.3–11.3) and the lowest VIM quintile of non-HDL-C (OR = 2.2, 95% CI = 1.3–3.0) were associated with higher MCI risk. Lower HDL-C trajectories (OR = 3.0, 95% CI = 1.6–5.7) and the lowest VIM quintile of total cholesterol (OR = 2.4, 95% CI = 1.5–3.9) were associated with higher AD risk. The inclusion of lipid-trajectory and VIM groups improved risk-model predictive performance independent of APOE genotype or PRS for AD and lipid levels. These results provide an important real-world perspective on the influence of lipid metabolism and blood-lipid levels on the development of stable MCI and AD.

10.1101/2024.09.27.24314494

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