Arun Arumugaperumal

Rajalakshmi Engineering College

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Sudhakar Sivasubramaniam

Manonmaniam Sundaranar University

Sayan Paul

The University of Texas Medical Branch at Galveston

Vaithilingaraja Arumugaswami

University of California, Los Angeles

Ponnuswamy Vijayaraghavan

Biotronik (India)

Samuel Gnana Prakash Vincent

Manonmaniam Sundaranar University

Subburathinam Balakrishnan

Manonmaniam Sundaranar University

Dinesh Kumar Sudalaimani

Periyar University

Mariadhas Valan Arasu

King Saud University

Naif Abdullah Al‐Dhabi

King Saud University

Sandhya Soman Syamala

Manonmaniam Sundaranar University

Cooperative Institutions

Manonmaniam Sundaranar University

St. John's National Academy of Health Sciences

Kalasalingam Academy of Research and Education

Madurai Kamaraj University

St. John's University

Bangalore University

Institute of Molecular Medicine

Center for Marine Sciences and Technology

Saveetha University

SRM Institute of Science and Technology

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Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae

Functional & Integrative Genomics (2022)

Sayan Paul Subburathinam Balakrishnan Arun Arumugaperumal Saranya Lathakumari Sandhya Soman Syamala

Oligochaeta (plant)

Blastema

10.1007/s10142-022-00849-5

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Citations (13)

Novel Sequential Screening and Enhanced Production of Fibrinolytic Enzyme byBacillussp. IND12 Using Response Surface Methodology in Solid-State Fermentation

BioMed Research International (2017)

Ponnuswamy Vijayaraghavan Priya Rajendran Samuel Gnana Prakash Vincent Arun Arumugaperumal Naif Abdullah Al‐Dhabi

Fibrinolytic enzymes have wide applications in clinical and waste treatment. Bacterial isolates were screened for fibrinolytic enzyme producing ability by skimmed milk agar plate using bromocresol green dye, fibrin plate method, zymography analysis, and goat blood clot lysis. After these sequential screenings, Bacillus sp. IND12 was selected for fibrinolytic enzyme production. Bacillus sp. IND12 effectively used cow dung for its growth and enzyme production (687 ± 6.5 U/g substrate). Further, the optimum bioprocess parameters were found out for maximum fibrinolytic enzyme production using cow dung as a low cost substrate under solid-state fermentation. Two-level full-factorial experiments revealed that moisture, pH, sucrose, peptone, and MgSO4 were the vital parameters with statistical significance (p < 0.001). Three factors (moisture, sucrose, and MgSO4) were further studied through experiments of central composite rotational design and response surface methodology. Enzyme production of optimized medium showed 4143 ± 12.31 U/g material, which was more than fourfold the initial enzyme production (978 ± 36.4 U/g). The analysis of variance showed that the developed response surface model was highly significant (p < 0.001). The fibrinolytic enzyme digested goat blood clot (100%), chicken skin (83 ± 3.6%), egg white (100%), and bovine serum albumin (29 ± 4.9%).

Solid-State Fermentation

10.1155/2017/3909657

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Citations (29)

Mitogenome of Eudrilus eugeniae

Figshare (2021)

Arun Arumugaperumal

Mitogenome sequence of the earthworm Eudrilus eugeniae

10.6084/m9.figshare.16702804

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Nutrition calculation in cattle farms

International Journal of Applied Engineering Research (2015)

V Kanchana P C Neeraj Arun Arumugaperumal

Source

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PeptCreatR: A Web App for Unique Peptides in Human

International Journal of Peptide Research and Therapeutics (2022)

Arun Arumugaperumal Deepa Velayudhan Krishna Sathyalakshmi Alaguponniah Krishnan Nallaperumal Sudhakar Sivasubramaniam

UniProt

Proteome

Identification

Human proteome project

Protein sequencing

10.1007/s10989-022-10375-4

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Citations (2)

A. Arun PhD thesis supplementary files

Figshare (2021)

Arun Arumugaperumal

A. Arun PhD thesis supplementary files

10.6084/m9.figshare.16656364

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Activation of mouse ear lobe tissue regeneration by metabolites of earthworm

JOURNAL OF EXPERIMENTAL ZOOLOGY INDIA (2022)

Vasanthakumar Ponesakki Sandhya Soman Syamala Sayan Paul Arun Arumugaperumal Padmashree Selvakumar

Oligochaeta (plant)

Lobe

Lumbricus terrestris

10.51470/jez.2023.26.1.1191

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Cow Dung Is a Novel Feedstock for Fibrinolytic Enzyme Production from Newly Isolated Bacillus sp. IND7 and Its Application in In Vitro Clot Lysis

Frontiers in Microbiology (2016)

Ponnuswamy Vijayaraghavan Arun Arumugaperumal Samuel Gnana Prakash Vincent Mariadhas Valan Arasu Naif Abdullah Al‐Dhabi

Bacterial fibrinolytic enzymes find great applications to treat and prevent cardiovascular diseases. The novel fibrinolytic enzymes from food grade organisms are useful for thrombolytic therapy. This study reports fibrinolytic enzyme production by Bacillus sp. IND7 in solid-state fermentation (SSF). In this study, cow dung was used as the cheap substrate for the production of fibrinolytic enzyme. Enzyme production was primarily improved by optimizing the nutrient and physical factors by one-variable-at-a-time approach. A statistical method (two-level full factorial design) was applied to investigate the significant variables. Of the different variables, pH, starch, and beef extract significantly influenced on the production of fibrinolytic enzyme (p < 0.05). The optimum levels of these significant factors were further investigated using response surface methodology. The optimum conditions for enhanced fibrinolytic enzyme production were 1.23% (w/w) starch and 0.3 % (w/w) beef extract with initial medium pH 9.0. Under the optimized conditions, cow dung substrate yielded 8,345 U/g substrate, and an overall 2.5-fold improvement in fibrinolytic enzyme production was achieved due to its optimization. This is the first report of fibrinolytic enzyme production using cow dung substrate from Bacillus sp. in SSF. The crude enzyme displayed potent activity on zymography and digested goat blood clot completely in in vitro condition.

Cow dung

Solid-State Fermentation

10.3389/fmicb.2016.00361

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Citations (39)

The draft genome of a new Verminephrobacter eiseniae strain: a nephridial symbiont of earthworms

Annals of Microbiology (2020)

Arun Arumugaperumal Sayan Paul Saranya Lathakumari Balasubramani Ravindran Sudhakar Sivasubramaniam

Abstract Purpose Verminephrobacter is a genus of symbiotic bacteria that live in the nephridia of earthworms. The bacteria are recruited during the embryonic stage of the worm and transferred from generation to generation in the same manner. The worm provides shelter and food for the bacteria. The bacteria deliver micronutrients to the worm. The present study reports the genome sequence assembly and annotation of a new strain of Verminephrobacter called Verminephrobacter eiseniae msu. Methods We separated the sequences of a new Verminephrobacter strain from the whole genome of Eisenia fetida using the sequence of V. eiseniae EF01-2, and the bacterial genome was assembled using the CLC Workbench. The de novo-assembled genome was annotated and analyzed for the protein domains, functions, and metabolic pathways. Besides, the multigenome comparison was performed to interpret the phylogenomic relationship of the strain with other proteobacteria. Result The FastqSifter sifted a total of 593,130 Verminephrobacter genomic reads. The de novo assembly of the reads generated 1832 contigs with a total genome size of 4.4 Mb. The Average Nucleotide Identity denoted the bacterium belongs to the species V. eiseniae , and the 16S rRNA analysis confirmed it as a new strain of V. eiseniae . The AUGUSTUS genome annotation predicted a total of 3809 protein-coding genes; of them, 3805 genes were identified from the homology search. Conclusion The bioinformatics analysis confirmed the bacterium is an isolate of V. eiseniae , and it was named Verminephrobacter eiseniae msu. The whole genome of the bacteria can be utilized as a useful resource to explore the area of symbiosis further.

Genome size

Sequence assembly

Homology

Comparative Genomics

10.1186/s13213-020-01549-w

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Citations (5)

Data on genome sequencing, analysis and annotation of a pathogenic Bacillus cereus 062011msu

Data in Brief (2018)

Rashmi Rathy Sayan Paul Vasanthakumar Ponesakki Kanniah Paulkumar Suriya Prabha Muthu

Bacillus species 062011 msu is a harmful pathogenic strain responsible for causing abscessation in sheep and goat population studied by Mariappan et al. (2012) [1]. The organism specifically targets the female sheep and goat population and results in the reduction of milk and meat production. In the present study, we have performed the whole genome sequencing of the pathogenic isolate using the Ion Torrent sequencing platform and generated 458,944 raw reads with an average length of 198.2 bp. The genome sequence was assembled, annotated and analysed for the genetic islands, metabolic pathways, orthologous groups, virulence factors and antibiotic resistance genes associated with the pathogen. Simultaneously the 16S rRNA sequencing study and genome sequence comparison data confirmed that the strain belongs to the species Bacillus cereus and exhibits 99% sequence homo;logy with the genomes of B. cereus ATCC 10987 and B. cereus FRI-35. Hence, we have renamed the organism as Bacillus cereus 062011msu. The Whole Genome Shotgun (WGS) project has been deposited at DDBJ/ENA/GenBank under the accession NTMF00000000 (https://www.ncbi.nlm.nih.gov/bioproject/PRJNA404036(SAMN07629099)).

Cereus

10.1016/j.dib.2017.12.054

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Citations (8)