Virginia J. Neelon

University of North Carolina at Chapel Hill

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Barbara W. Carlson

University of Oklahoma Health Sciences Center

Marilyn Hartman

University of North Carolina at Chapel Hill

John R. Carlson

University of Oklahoma Health Sciences Center

Jo Ann Dalton

University of Liverpool

John S. Carlson

Michigan State University

Kathy R. Alden

University of North Carolina at Chapel Hill

Dennis J. Cheek

Texas Christian University

Sunil Dogra

Post Graduate Institute of Medical Education and Research

John S. Preisser

University of North Carolina at Chapel Hill

Debra J. Barksdale

University of North Carolina at Greensboro

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University of North Carolina at Chapel Hill

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University of Massachusetts Dartmouth

The University of Texas MD Anderson Cancer Center

Duke University

University of California, San Francisco

Duke Medical Center

The University of Texas Health Science Center at Houston

Amsterdam University Medical Centers

Amsterdam UMC Location VUmc

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The assessment of acute confusion as part of nursing care

Applied Nursing Research (1997)

Judith Miller Virginia J. Neelon Mary T. Champagne Donald E. Bailey Nicholas Ngʼandu

Confusion

Acute care

Nursing assessment

Nursing staff

10.1016/s0897-1897(97)80237-6

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Citations (21)

Cerebrovascular Disease and Patterns of Cerebral Oxygenation During Sleep in Elders

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2009)

Barbara W. Carlson Virginia J. Neelon John R. Carlson Marilyn Hartman S. Dogra

Sleep

10.17615/41yq-wp94

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Citations (0)

Exploratory Analysis of Cerebral Oxygen Reserves During Sleep Onset in Older and Younger Adults

Journal of the American Geriatrics Society (2008)

Barbara W. Carlson Virginia J. Neelon John R. Carlson Marilyn Hartman Sunil Dogra

OBJECTIVES: To explore differences in cerebral oxygen reserves during sleep in old and young adults. DESIGN: Descriptive cross‐sectional study. SETTING: General clinical research center. PARTICIPANTS: Nine old (aged 65–84) and 10 young (aged 21–39) adults. MEASUREMENTS: Subjects were monitored during the first nightly sleep cycle using standard polysomnography, including measures of arterial oxyhemoglobin saturation (SaO 2 ). Changes in regional cerebral oxyhemoglobin saturation (rcSO 2 ) were used to estimate cerebral oxygen reserves. General linear models were used to test group differences in the change in SaO 2 and rcSO 2 during sleep. RESULTS: Older subjects had lower SaO 2 than young subjects before sleep (baseline) ( F (1,18) =5.1, P =.04) and during sleep ( F (1,18) =10.7, P =.01). During sleep, half of the older subjects and none of the younger ones had SaO 2 values below 95%. In addition, the older subjects had more periods of oxygen desaturation (drops in SaO 2 ≥4%) (chi‐square=24.3, P =.01) and lower SaO 2 levels during desaturation ( F (1,18) =11.1, P <.01). Although baseline values were similar, rcSO 2 decreased during sleep 2.1% in older subjects ( F (1,8) =3.8, P =.05) but increased 2.1% during sleep in younger subjects ( F (1,9) =4.6, P =.04). When the older subjects awakened from sleep, rcSO 2 , but not SaO 2 , returned to baseline; both returned to baseline in younger subjects. CONCLUSION: This exploratory analysis generated the hypothesis that lower SaO 2 , combined with declines in regional blood flow, contributes to decline in cerebral oxygen reserves during sleep in older subjects. Further study will assess the effects of factors (e.g., medical conditions, subclinical disorders, and sleep architecture) that might account for these differences.

Sleep

Exploratory analysis

10.1111/j.1532-5415.2008.01672.x

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Citations (5)

Table of contents

Heart & Lung (2004)

Patti Staples Wendy Earle Rebecca Gary Carla A. Sueta Molly C. Dougherty

Table (database)

10.1016/s0147-9563(04)00113-x

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Cerebral Oxygenation in Wake and During Sleep and Its Relationship to Cognitive Function in Community-Dwelling Older Adults Without Sleep Disordered Breathing

Carolina Digital Repository (University of North Carolina at Chapel Hill) (2011)

Barbara W. Carlson Virginia J. Neelon John R. Carlson Marilyn Hartman Donald L. Bliwise

Sleep

Sleep-Disordered Breathing

Sleep and breathing

10.17615/xc6p-fy39

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Evaluation of Variables to Characterize Respiratory Periodicity during Sleep in Older Adults

Biological Research For Nursing (2002)

Barbara W. Carlson Virginia J. Neelon

Reliable markers of early neurological decline might guide interventions to prevent or reverse cognitive decline in older adults. Because cognitive decline is associated with hypoxemia during sleep, the authors examined 3 respiratory periodicity variables in 5 older adults. Subjects were monitored overnight using standard polysomnography. From the inductance band signal, the authors calculated the variability in duration of breathing cycles measured by standard deviation of interbreath intervals (sdIBI), frequency of breathing cycles measured by standard deviation of interbreath frequencies (sdIBF), and amplitude of breathing cycles measured by standard deviation of breathing cycle amplitudes (sdAMP). Logistic regression analysis and kappa coefficients identified variables that reliably detected 5-minute segments having central or obstructive apneas or body movements. An sdIBF 4.5 cpm identified body movements (sensitivity= 0.96, specificity = 0.96, kappa = 0.90). An sdIBI > 1.2 seconds identified central apneas (sensitivity = 0.86, specificity = 0.99, kappa= 0.86), and an sdIBI 1.68 seconds identified segments with 3 central apneas (sensitivity = 0.90, specificity = 0.89, kappa = 0.89). An sdAMP 0.1 V and an sdIBF 1.5 cpm identified obstructive apneas (kappa = 0.91). Data support the potential of these variables to identify central and obstructive apneas and to classify individuals according to different patterns of respiratory periodicity.

Kappa

10.1177/10900402003004003

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Citations (4)

Measures of Ventricular-Arterial Coupling and Incident Heart Failure With Preserved Ejection Fraction: A Matched Case-Control Analysis

Journal of Cardiac Failure (2017)

Carolyn L. Lekavich Debra J. Barksdale Jia-Rong Wu Virginia J. Neelon Jamie Crandell

10.1016/j.cardfail.2017.07.395

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Citations (4)

Approaches to Pain in Infants and Children: A Discussion

Margaret Shandor Miles Virginia J. Neelon