Seoho Lee

University of Chicago

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Why are fewer women selecting a career in radiology

Rebecca Zener Kari L. Visscher Seoho Lee Maya Ricketts S. T. Speer

Poster: ECR 2013 / C-1127 / Why are fewer women selecting a career in radiology? by: R. Zener , K. L. Visscher, S. Y. Lee, M. Ricketts, S. Speer, J. Williams, D. Wiseman; London, ON/CA

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Photo-double-ionization of ethylene and acetylene near threshold

Physical Review A (2014)

B. Gaire Seoho Lee Daniel J. Haxton Philipp Pelz I. Bocharova

We present kinematically complete measurements of the photo-double-ionization of ethylene (double CC bond) and acetylene (triple CC bond) hydrocarbons just above the double-ionization threshold. We discuss the results in terms of the coincident kinetic energy of the photoelectrons and the nuclear kinetic-energy release of the recoiling ions. We have incorporated quantum chemistry calculations to interpret which of the electronic states of the dication have been populated and trace the various subsequent fragmentation channels. We suggest pathways that involve the electronic ground and excited states of the precursor ethylene dication and explore the strong influence of the conical intersections between the different electronic states. The nondissociative ionization yield is small in ethylene and high in acetylene when compared with the dissociative ionization channels. The reason for such a striking difference is explained in part on the basis of a propensity rule that influences the population of states in the photo-double-ionization of a centrosymmetric closed-shell molecule by favoring singlet ungerade and triplet gerade final states. This propensity rule and the calculated potential-energy surfaces clarify a picture of the dynamics leading to the observed dication dissociation products.

Dication

Double ionization

Fragmentation

Acetylene

10.1103/physreva.89.013403

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Citations (45)

Novel surgical video-based education resource for surgical case preparation among medical students: results from a randomized controlled trial

Global Surgical Education - Journal of the Association for Surgical Education (2024)

Matthew Zeller Emma K. Sterling Manuj M. Shah Seoho Lee Christopher R. D’Adamo

10.1007/s44186-024-00297-8

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PKCδ germline variants and genetic deletion in mice augment antitumor immunity through regulation of myeloid cells

Cancer Immunology Research (2025)

Kyle R. Cron Ayelet Sivan Keston Aquino-Michaels Andrea Ziblat Emily F. Higgs

Based on the notion that hypomorphic germline genetic variants are linked to autoimmune diseases, we reasoned that novel targets for cancer immunotherapy might be identified through germline variants associated with greater T-cell infiltration into tumors. Here, we report that while investigating germline polymorphisms associated with a tumor immune gene signature, we identified PKCδ as a candidate. Genetic deletion of PKCδ in mice resulted in improved endogenous antitumor immunity and increased efficacy of anti-PD-L1. Single-cell RNA sequencing revealed myeloid cell expression of Prkcd, and PKCδ deletion caused a shift in macrophage gene expression from an M2-like to an M1-like phenotype. Conditional deletion of PKCδ in myeloid cells recapitulated improved tumor control that was augmented further with anti-PD-L1. Analysis of clinical samples confirmed an association between PRKCD variants and M1/M2 phenotype, as well as between a PKCδ KO-like gene signature and clinical benefit from anti-PD-1. Our results identify PKCδ as a candidate therapeutic target that modulates myeloid cell states.

Augment

10.1158/2326-6066.cir-23-0999

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