Yu-Ming Tsao

National Chung Cheng University

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Hsiang‐Chen Wang

National Chung Cheng University

Arvind Mukundan

National Chung Cheng University

Chien‐Wei Huang

National Yang Ming Chiao Tung University

Hôǹg Thái Nguyêñ

National Chung Cheng University

Riya Karmakar

National Chung Cheng University

Kai-Yao Yang

Kaohsiung Armed Forces General Hospital

Fen-Chi Lin

Kaohsiung Armed Forces General Hospital

Song-Cun Lu

National Chung Cheng University

ВФ

В.Е. Федоров

Chelyabinsk State University

S. B. Artemkina

Nikolaev Institute of Inorganic Chemistry

Cooperative Institutions

National Chung Cheng University

National Yang Ming Chiao Tung University

Kaohsiung Armed Forces General Hospital

National Taiwan University Hospital

National Taiwan University

Innovative Research (United States)

Chia-Yi Christian Hospital

Kaohsiung Medical University

National Tsing Hua University

Changhua Christian Hospital

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Optical and Material Characteristics of MoS2/Cu2O Sensor for Detection of Lung Cancer Cell Types in Hydroplegia

International Journal of Molecular Sciences (2022)

Arvind Mukundan Shih‐Wei Feng Yu-Hsin Weng Yu-Ming Tsao S. B. Artemkina

In this study, n-type MoS2 monolayer flakes are grown through chemical vapor deposition (CVD), and a p-type Cu2O thin film is grown via electrochemical deposition. The crystal structure of the grown MoS2 flakes is analyzed through transmission electron microscopy. The monolayer structure of the MoS2 flakes is verified with Raman spectroscopy, multiphoton excitation microscopy, atomic force microscopy, and photoluminescence (PL) measurements. After the preliminary processing of the grown MoS2 flakes, the sample is then transferred onto a Cu2O thin film to complete a p-n heterogeneous structure. Data are confirmed via scanning electron microscopy, SHG, and Raman mapping measurements. The luminous energy gap between the two materials is examined through PL measurements. Results reveal that the thickness of the single-layer MoS2 film is 0.7 nm. PL mapping shows a micro signal generated at the 627 nm wavelength, which belongs to the B2 excitons of MoS2 and tends to increase gradually when it approaches 670 nm. Finally, the biosensor is used to detect lung cancer cell types in hydroplegia significantly reducing the current busy procedures and longer waiting time for detection. The results suggest that the fabricated sensor is highly sensitive to the change in the photocurrent with the number of each cell, the linear regression of the three cell types is as high as 99%. By measuring the slope of the photocurrent, we can identify the type of cells and the number of cells.

Photocurrent

10.3390/ijms23094745

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Large area MoS2 thin film growth by direct sulfurization

Research Square (Research Square) (2023)

Kai-Yao Yang Hôǹg Thái Nguyêñ Yu-Ming Tsao S. B. Artemkina В.Е. Федоров

Abstract In this study, we present the growth of monolayer MoS 2 (molybdenum disulfide) film. Mo (molybdenum) film was formed on a sapphire substrate through e-beam evaporation, and triangular MoS 2 film was grown by direct sulfurization. First, the growth of MoS 2 was observed under an optical microscope. The number of MoS 2 layers was analyzed by Raman spectrum, atomic force microscope (AFM), and photoluminescence spectroscopy (PL) measurement. Different sapphire substrate regions have different growth conditions of MoS 2 . The growth of MoS 2 is optimized by controlling the amount and location of precursors, adjusting the appropriate growing temperature and time, and establishing proper ventilation. Experimental results show the successful growth of a large-area single-layer MoS 2 on a sapphire substrate through direct sulfurization under a suitable environment. The thickness of the MoS2 film determined by AFM measurement is about 0.73 nm. The peak difference between the Raman measurement shift of 386 and 405 cm-1 is 19.1 cm-1, and the peak of PL measurement is about 677 nm, which is converted into energy of 1.83 eV, which is the size of the direct energy gap of the MoS 2 thin film. The results verify the distribution of the number of grown layers. Based on the observation of the optical microscope (OM) images, MoS 2 continuously grows from a single layer of discretely distributed triangular single-crystal grains into a single-layer large-area MoS 2 film. This work provides a reference for growing MoS2 in a large area. We expect to apply this structure to various heterojunctions, sensors, solar cells, and thin-film transistors.

Molybdenum disulfide

10.21203/rs.3.rs-2679813/v1

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Hyperspectral Imaging Applied to Identify Early Esophageal Cancer

Yu-Ming Tsao Arvind Mukundan Riya Karmakar Song-Cun Lu Hôǹg Thái Nguyêñ

10.1109/cleo-pr60912.2024.10676726

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Assessment of Narrow Band Imaging Algorithm for Video Capsule Endoscopy Based on Decorrelated Color Space for Esophageal Cancer

Kai-Yao Yang Yu-Jen Fang Riya Karmakar Arvind Mukundan Yu-Ming Tsao

Video capsule endoscopy (VCE) is increasingly used to decrease the discomfort among patients owing to its small size. However, VCE has a major drawback of not having narrow band imaging (NBI) functionality. The current VCE has the traditional white light imaging (WLI) only, which has poor performance in the computer-aided detection (CAD) of different types of cancer compared with NBI. Specific cancers, such as esophageal cancer (EC), do not exhibit any early biomarkers, making their early detection difficult. In most cases, the symptoms are unnoticeable, and EC is diagnosed only in later stages, making its 5-year survival rate below 20% on an average. NBI filters provide particular wavelengths that increase the contrast and enhance certain features of the mucosa, thereby enabling early identification of EC. However, VCE does not have a slot for NBI functionality because its size cannot be increased. Hence, NBI image conversion from WLI can be achieved only in post-processing at present. In this study, a complete arithmetic assessment of the decorrelated color space was conducted to generate NBI images from WLI images for VCE of the esophagus. Three parameters, namely, structural similarity index metric (SSIM), entropy, and peak-signal-to-noise ratio (PSNR), were used to asses the simulated NBI images. Results show the good performance of the NBI image reproduction method, with SSIM, entropy difference, and PSNR values of 93.215%, 4.360, and 28.064 dB, respectively.

Color difference

Gray level

10.20944/preprints202308.0280.v1

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Growth Mechanism of Periodic-Structured MoS2 by Transmission Electron Microscopy

Nanomaterials (2021)

Arvind Mukundan Yu-Ming Tsao S. B. Artemkina В.Е. Федоров Hsiang‐Chen Wang

Molybdenum disulfide (MoS2) was grown on a laser-processed periodic-hole sapphire substrate through chemical vapor deposition. The main purpose was to investigate the mechanism of MoS2 growth in substrate with a periodic structure. By controlling the amount and position of the precursor, adjusting the growth temperature and time, and setting the flow rate of argon gas, MoS2 grew in the region of the periodic holes. A series of various growth layer analyses of MoS2 were then confirmed by Raman spectroscopy, photoluminescence spectroscopy, and atomic force microscopy. Finally, the growth mechanism was studied by transmission electron microscopy (TEM). The experimental results show that in the appropriate environment, MoS2 can be successfully grown on substrate with periodic holes, and the number of growth layers can be determined through measurements. By observing the growth mechanism, composition analysis, and selected area electron diffraction diagram by TEM, we comprehensively understand the growth phenomenon. The results of this research can serve as a reference for the large-scale periodic growth of MoS2. The production of periodic structures by laser drilling is advantageous, as it is relatively simpler than other methods.

Molybdenum disulfide

10.3390/nano12010135

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Detection of Air Pollution Using Hyperspectral Imaging

Riya Karmakai Arvind Mukundan Yu-Ming Tsao Song-Cun Lu Hôǹg Thái Nguyêñ

10.1109/cleo-pr60912.2024.10676637

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Development of narrow-band image imaging based on hyperspectral image conversion technology for capsule endoscopy

Yu-Ming Tsao Arvind Mukundan Songcun Lu Hsiang‐Chen Wang Yen‐Po Wang

Human upper gastrointestinal lesions include esophageal cancer, Barrett's esophagus, gastroesophageal reflux, etc. Through the diagnosis of upper gastrointestinal endoscopy, it is possible to capture images of symptoms and study relevant lesion in real time. The traditional inspection uses a tubular endoscope with a diameter of about 1 cm. It is inserted from the mouth, passes through the throat, esophagus, and finally reaches the stomach. During the inspection, the symptoms of the upper gastrointestinal are checked step by step. Due to the caliber of the pipeline equipment, it often causes discomfort at the throat. A new type of capsule endoscope with wires was born accordingly. It is mainly used to assist in the examination of symptoms in the upper gastrointestinal (esophagus, stomach, and duodenum). The patient can only swallow the capsule endoscope orally, just like swallowing capsule medicine. Follow-up doctors can control the posture of the capsule endoscope through the magnetic control handle to do examinations and obtain required images. However, compared with traditional endoscopes, capsule endoscopes cannot be equipped with additional narrow-band light sources, optical magnification and other functions on the endoscope due to the need for simplified volume, and the controllability of symptom observation is slightly insufficient. Based on this deficiency, this study deeply explores the narrow-band imaging technology that can be applied to capsule endoscopy. With the introduction of hyperspectral imaging technology, it reconstructs the capsule endoscopy image into spectral information, and combines the principle of color reproduction to optimize adjustment. Light source information, and finally reproduce the simulated narrowband image. Based on this narrow-band imaging technology, the narrow-band imaging function of the capsule endoscope can be endowed, which can help clinical examination to observe symptoms.

Endoscope

10.1117/12.2688844

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A 1~50mA 20ns Settling Time Low Dropout Regulator

2021 28th IEEE International Conference on Electronics, Circuits, and Systems (ICECS) (2023)

Hong‐Yi Huang Yu-Ming Tsao Angelo Nico M. Daroy Kuo-Hsing Cheng

As technology progresses, semiconductor devices become smaller while operating frequencies become faster. This work presents a fast-switching low dropout regulator (LDO). Previous studies on LDO aimed to improve the power supply rejection performance at high frequencies by connecting a large capacitor off-chip at the output. More recent studies implemented on-chip capacitors; however, this still occupies a large chip area. In this work, chip area is reduced by using NMOSCAP instead of MIM capacitors. The chip is implemented using the a $0.18 \mu \mathrm{m}$ process. The core area is $215 \mu \mathrm{m} \times 165 \mu \mathrm{m}$. The input voltage is 2V and the output voltage is 1.8V. The settling time is less than 20ns when the load current switches between 1mA and 50mA.

Low-dropout regulator

Settling time

Dropout (neural networks)

10.1109/icecs58634.2023.10382892

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Fabrication of MoS₂ nanoparticle dispersions using ultrasonic methods: synthesis techniques and optical characterization

Optical Materials Express (2024)

Chun-Liang Lai Riya Karmakar Yu-Ming Tsao Song-Cun Lu Arvind Mukundan

This study outlines the process of preparing a dispersion of MoS 2 nanoparticle from micron sized MoS 2 powder using ultrasonic methods. The optical characteristics of this dispersion were investigated using optical measurement techniques. N-methyl-2-pyrrolidone is chosen as the dispersion solvent due to its surface energy closely matching that of MoS 2 . Consequently, the dispersion that ensued exhibits commendable stability. The MoS 2 dispersion underwent analysis through EDX, scanning electron microscopy, and transmission electron microscopy techniques to examine the correlation between the size of the MoS 2 nanoparticles and the morphology of the dispersion. The dispersion color intensifies with the increase in the wavelength. A He-Cd laser with a wavelength of 325 nm was used to stimulate and generate the matching light source for the generated samples to leverage the photoluminescent attribute of MoS 2 nanoparticles within the range of less than 100 nm. In the Raman measurement graph, distinct peaks can be observed in the generated nanoparticles, providing evidence of their material qualities. The surface morphology of the optical microscopic image was assessed using ultra-spectral imaging technology, allowing for the measurement and acquisition of the associated wavelength spectrum. The particle size in the dispersion was measured using the dynamic light scattering technique. These tests demonstrate that the process can be fine-tuned by adjusting parameters, such as ultrasonic oscillation time and centrifugal time. This process can also yield MoS 2 nanoparticle dispersions in various sizes, each exhibiting distinct photoluminescence characteristics corresponding to the excited light wavelength.

10.1364/ome.528709

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Citations (1)

Genetic copy number variants in myocardial infarction patients with hyperlipidemia

BMC Genomics (2011)

Wei-Chung Shia Tien-Hsiung Ku Yu-Ming Tsao Chien‐Hsun Hsia Yung‐Ming Chang

Abstract Background Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it causes atherosclerosis directly. In recent years, copy number variation (CNV) has been analyzed in genomewide association studies of complex diseases. In this study, CNV was analyzed in blood samples and SNP arrays from 31 myocardial infarction patients with hyperlipidemia. Results We identified seven CNV regions that were associated significantly with hyperlipidemia and myocardial infarction in our patients through multistage analysis (P<0.001), at 1p21.3, 1q31.2 ( CDC73 ), 1q42.2 ( DISC1 ), 3p21.31 ( CDCP1 ), 10q11.21 ( RET ) 12p12.3 ( PIK3C2G ) and 16q23.3 ( CDH13 ), respectively. In particular, the CNV region at 10q11.21 was examined by quantitative real-time PCR, the results of which were consistent with microarray findings. Conclusions Our preliminary results constitute an alternative method of evaluating the relationship between CNV regions and cardiovascular disease. These susceptibility CNV regions may be used as biomarkers for early-stage diagnosis of hyperlipidemia and myocardial infarction, rendering them valuable for further research and discussion.

Hyperlipidemia

SNP

10.1186/1471-2164-12-s3-s23

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Citations (40)