The CKD epidemic is a worldwide public health problem, associated with premature death, increased morbidity. Renal transplantation is considered to be the best renal replacement therapy option for patients with advanced chronic kidney disease .After renal transplantation there is expected improvement in mineral bone status of patients. However , hyperparathyroidism completely resolves in only 30% of recipients within the first year post transplantation. In some studies, hyperparathyroidism in the post-transplant period was associated with increased cortical and trabecular bone losses and with higher fracture risk .
This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVID-19 (NCRC).NCRC is an on-going data collection platform operational in 42 hospitals across India. Data of hospitalized COVID-19 patients enrolled in NCRC between 1st September 2020 to 26th October 2021 were examined.Analysis of 29 509 hospitalized, adult COVID-19 patients [mean (SD) age: 51.1 (16.2) year; male: 18 752 (63.6%)] showed that 15 678 (53.1%) had at least one comorbidity. Among 25 715 (87.1%) symptomatic patients, fever was the commonest symptom (72.3%) followed by shortness of breath (48.9%) and dry cough (45.5%). In-hospital mortality was 14.5% (n = 3957). Adjusted odds of dying were significantly higher in age group ≥60 years, males, with diabetes, chronic kidney diseases, chronic liver disease, malignancy and tuberculosis, presenting with dyspnoea and neurological symptoms. WHO ordinal scale 4 or above at admission carried the highest odds of dying [5.6 (95% CI: 4.6-7.0)]. Patients receiving one [OR: 0.5 (95% CI: 0.4-0.7)] or two doses of anti-SARS CoV-2 vaccine [OR: 0.4 (95% CI: 0.3-0.7)] were protected from in-hospital mortality.WHO ordinal scale at admission is the most important independent predictor for in-hospital death in COVID-19 patients. Anti-SARS-CoV2 vaccination provides significant protection against mortality.
Summary Introduction The hallmark of chronic myeloid leukemia ( CML ) is the presence of Philadelphia chromosome, its resultant fusion transcript ( BCR ‐ ABL 1 ), and fusion protein (p210). Alternate breakpoints in BCR (m‐bcr, μ‐bcr, and others) or ABL 1 result in the expression of few rare fusion transcripts (e19a2, e1a2, e13a3, e14a3) and fusion proteins (p190, p200, p225) whose exact clinical significance remains to be determined. Methods Our study was designed to determine the type and frequency of BCR ‐ ABL 1 fusion transcripts in 1260 CML patients and to analyze the prognosis and treatment response in patients harboring rare BCR ‐ ABL 1 fusion transcripts. Results The frequency of various BCR ‐ ABL 1 fusion transcripts was as follows: e14a2 (60%), e13a2 (34.3%), e1a2 (1.2%), e1a2 + e13a2 (2.0%), e1a2 + e14a2 (1.8%), e19a2 (0.3%), and e14a3 (0.3%). CML patients with e1a2 transcripts had higher rates of disease progression, resistance, or suboptimal response to imatinib and failed to achieve major molecular response. Conclusion Characterization of the specific fusion transcript in CML patients is important owing to the difference in prognosis and response to therapy in addition to the conventional need for monitoring treatment response. CML patients with e1a2 transcripts have to be closely monitored due to the high incidence of disease progression and treatment resistance/failure.
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