Mariia Solomatina

Federal Research Center of Fundamental and Translational Medicine

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Kirill Sharshov

Federal Research Center of Fundamental and Translational Medicine

АМ

А. М. Шестопалов

Federal Research Center of Fundamental and Translational Medicine

Ivan Sobolev

Federal Research Center of Fundamental and Translational Medicine

Elena A. Prokopyeva

Federal Research Center of Fundamental and Translational Medicine

Anastasia Suvorova

Federal Research Center of Fundamental and Translational Medicine

Tatyana Murashkina

Federal Research Center of Fundamental and Translational Medicine

Daria Danilenko

Research Institute of Influenza

АY

А. Yu. Alekseev

Dagestan State University

Olga Kurskaya

Federal Research Center of Fundamental and Translational Medicine

Artem Fadeev

MIREA - Russian Technological University

Cooperative Institutions

Federal Research Center of Fundamental and Translational Medicine

Research Institute of Influenza

Siberian Branch of the Russian Academy of Sciences

All-Russian Research Institute for Animal Health

Russian Academy of Sciences

Dagestan State University

Siberian Research Institute of Agriculture and Peat

Ministry of Health of the Russian Federation

Astrakhan Biosphere Nature Reserve

Institute of Virology of the Slovak Academy of Sciences

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Experimental Infection of Adapted Influenza B Virus in Mice Model

Elena A. Prokopyeva Olga Kurskaya Ivan Sobolev Mariia Solomatina Tatyana Murashkina

Over the years influenza B virus (IBV) contribute annual disease and can lead to serious respiratory disease among humans. More attention should be paid to the mammalian adaptive processes of B viruses and development of vaccines against current influenza. Because of preclinical trials of anti-influenza drugs are conducted mainly on mice, we developed adequate animal model using antigenically-relevant IBV strain for testing anti-influenza drugs and protective efficacy of flu vaccines. We serially passaged Victoria lineage (clade 1A) IBV 17 times in BALB/c mice. The adaptive amino acid substitutions were found in HA (T214I) and NA (D432N). By the electron microscopic examination, we showed spherical and elliptical shapes of IBV. Light microscopy showed that mouse-adapted B virus caused influenza pneumonia on day 6 post inoculation. We evaluated the illness pathogenicity, viral load and histopathological features of mouse-adapted IBV and estimated anti-influenza drugs and vaccine efficiency in vitro and in vivo. Assessment of investigational anti-influenza drug oseltamivir ethoxisuccinate and flu vaccine Ultrix® revealed effectivity against our mouse-adapted influenza B virus.

Oseltamivir

Strain (injury)

10.20944/preprints202002.0022.v1

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Age management - Bydlení seniorů

Adéla Hýlová Mariia Solomatina Dominika Vlčková Nela Faltusová Anna Václavová

Jedna se o výstup projektu OP VK s nazvem: Partnerstvi subjektů meziuniverzitni studentske sitě: CZ.1.07/2.4.00/31.0157. Hlavnim cilem projektu je navrhnout konkretni opatřeni ci kroky, ktere by zlepsily kvalitu života starsich obyvatel města. Prace ma klast důraz zejmena na rozsiřeni vhodne nabidky bydleni pro různe skupiny osob seniorskeho věku, avsak je možne rozsah prace rozsiřit i na dalsi aspekty života ve městě, ktere se s danou cilovou skupinou poji. Prace se opira o Narodni akcni plan, podporujici pozitivni starnuti pro obdobi let 2013 až 2017, je zaměřena zejmena na seniory, kteři jsou ekonomicky ci socialně znevýhodněni, žiji v pronajmu, ale zajimaji se o hledani alternativnich možnosti bydleni, neboť se citi ohroženi možným zvýsenim najemneho nebo samotou. Zakladni myslenkou cele prace je nevycleňovat seniory ze spolecnosti, ale naopak je do ni v ramci možnosti integrovat. Proto je prace zaměřena na model sdileneho bydleni, cili cohousing, v uvahu jsou vzaty take socio - demograficke analýzy a prognozy pro město Brno.

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Je ruská společnost anomická

Mariia Solomatina

Tato bakalařska prace se věnuje otazce anomie v Rusku v uplynulých dvou desetiletich. Pomoci dostupných dat z Evropskeho výzkumu hodnot, statistik sebevražednosti a kriminality a take setřeni, ktera byla provedena ruskými sociologickými agenturami WCIOM a Levada-center, sleduje, jak se měnila mira anomie ve spolecnosti v průběhu casu a v různých sektorech ruske populace. Zvolene indikatory odpovidaji teoriim anomie Emile Durkheima, Roberta Mertona a Leo Sroleho, na jejichž dilech se zaklada teoretický ramec prace. Pozornost se věnuje předevsim dopadům procesu perestrojky na socialni kohezi Ruska. Tento proces probihal v letech 1985-1991 a zahrnoval komplex ekonomických, politických a jiných transformaci. Kulturni trauma, ktere byla vyvolano nahlou změnou normativně-hodnotoveho systemu, a změna principu socialni stratifikace, kvůli němuž se Rusko polarizovalo na chudou větsinu a bohatou mensinu, se staly hlavnimi přicinami prudkeho zvýseni miry anomie ve spolecnosti a jeji dezintegrace. To se projevilo zaprve ve zvýseni poctu sebevražd a rozsiřeni deviantniho chovani, jejichž kulminacni body nastaly v 90. letech 20. stoleti. Zadruhe se to odrazilo v postojich a nazorech obyvatel, ktere charakterizuje ztrata jistoty co se budoucnosti týce a nedůvěra vůci vladě a jiným lidem. V největsim ohroženi se ocitla mlada generace, ktera byla nucena se socializovat ve vysoce anomickem prostředi.

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Experimental Infection Using Mouse-Adapted Influenza B Virus in a Mouse Model

Viruses (2020)

Elena A. Prokopyeva Olga Kurskaya Ivan Sobolev Mariia Solomatina Tatyana Murashkina

Every year, influenza B viruses (IBVs) contribute to annual illness, and infection can lead to serious respiratory disease among humans. More attention is needed in several areas, such as increasing virulence or pathogenicity of circulating B viruses and developing vaccines against current influenza. Since preclinical trials of anti-influenza drugs are mainly conducted in mice, we developed an appropriate infection model, using an antigenically-relevant IBV strain, for furtherance of anti-influenza drug testing and influenza vaccine protective efficacy analysis. A Victoria lineage (clade 1A) IBV was serially passaged 17 times in BALB/c mice, and adaptive amino acid substitutions were found in hemagglutinin (HA) (T214I) and neuraminidase (NA) (D432N). By electron microscopy, spherical and elliptical IBV forms were noted. Light microscopy showed that mouse-adapted IBVs caused influenza pneumonia on day 6 post inoculation. We evaluated the illness pathogenicity, viral load, and histopathological features of mouse-adapted IBVs and estimated anti-influenza drugs and vaccine efficiency in vitro and in vivo. Assessment of an investigational anti-influenza drug (oseltamivir ethoxysuccinate) and an influenza vaccine (Ultrix®, SPBNIIVS, Saint Petersburg, Russia) showed effectiveness against the mouse-adapted influenza B virus.

Oseltamivir

Neuraminidase inhibitor

H5N1 genetic structure

10.3390/v12040470

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Citations (8)