A rare case of composite glandular–endocrine cell carcinoma of the common bile duct is presented. Histologically, this tumor consisted of adenocarcinoma and small‐cell neuroendocrine carcinoma, with a transition between the two components. The two distinct areas of the tumor were immunohistochemically different, whereas the transitional zone exhibited characteristics of both areas. These features suggest that the tumor arose from a multipotential stem cell. Although it has been reported that the presence of neuroendocrine differentiation in carcinomas indicates a poor prognosis, the patient in the present case was well at the time of writing this report. This may be due to the fact that adenocarcinoma, which characteristically has a low proliferative activity, constituted the majority of the tumor.

Enteroendocrine cell

Neuroendocrine differentiation

10.1046/j.1440-1827.2001.01227.x

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Citations (23)

A Case of Gastric Malignant Lymphoma Complicated with Gastro-bronchial Fistula during Neoadjuvant Chemotherapy.

The Japanese Journal of Gastroenterological Surgery (1999)

Yongxin Chen Seiji Sato Daisuke Mori Genichiro Edakuni Kenji Kitahara

胃悪性リンパ腫はそれ自体は比較的まれな疾患であるが, 胃気管支瘻を伴うことは極めてまれである. 今回, 本疾患の1切除例を経験したので報告する. 症例は81歳の女性. 突然の嘔吐と食欲不振を主訴とし, 精査の結果進行大腸癌と胃悪性リンパ腫の合併と診断した. CT検査にて胃の腫瘍は脾臓, 膵臓, 横隔膜への直接浸潤が疑われ, 胃癌取扱い規約によるstage IIIaより進行した症例と判断したため, 大腸癌に対する右半結腸切除術後, 胃悪性リンパ腫に対し術前化学療法を施行する方針とした. 化学療法施行中に胃穿孔を疑ったが, 膿瘍が左横隔膜下に限局化したため化学療法を継続しえた. さらに化学療法を2クール追加後, 上部消化管造影にて胃気管支瘻が判明した. 化学療法施行終了後2週目に待機手術として胃全摘+脾摘+横隔膜瘻孔部合併切除にて腫瘍を切除しえた. 合併症を生じながらも術前化学療法が著効を呈した症例と考えられた.

Gastro-

10.5833/jjgs.32.2360

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Citations (0)

Breast Masses with Peripheral Rim Enhancement on Dynamic Contrast-enhanced MR Images: Correlation of MR Findings with Histologic Features and Expression of Growth Factors

Radiology (2000)

Roka Namoto Matsubayashi Yoshitomo Matsuo Genichiro Edakuni Toshimi Satoh Osamu Tokunaga

To investigate the histologic bases of rim enhancement of breast masses demonstrated on dynamic contrast material-enhanced magnetic resonance (MR) images.Dynamic MR images of breast lesions (invasive carcinoma, n = 29; other, n = 6) in 35 women were reviewed. In each patient, subtraction images of the dynamic contrast-enhanced study were obtained, and early and delayed rim enhancement and delayed internal enhancement were evaluated. The MR findings were correlated with the ratio of microvessel density of the peripheral to the central portion of the lesion, fibrosis, and other histologic features, including expression of vascular endothelial growth factor (VEGF) and transforming growth factor ss1.Early rim enhancement was observed in 29% and delayed rim enhancement was noted in 60% of all patients. Small cancer nests, a high ratio of peripheral-to-central microvessel density, peripheral VEGF expression, and a low ratio of peripheral-to-central fibrosis were correlated with early rim enhancement. Delayed rim enhancement was correlated with a high degree of fibrosis and inflammatory changes. Delayed internal enhancement was correlated with a high degree of fibrosis.Rim enhancement of breast lesions at MR imaging is due to a combination of angiogenesis, distribution and degree of fibrosis, expression pattern of VEGF, and various histologic features.

Dynamic contrast

Contrast Enhancement

Dynamic Contrast-Enhanced MRI

10.1148/radiology.217.3.r00dc07841

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Citations (150)

Expression of the hepatocyte growth factor/c‐Met pathway is increased at the cancer front in breast carcinoma

Pathology International (2001)

Genichiro Edakuni Eizaburo Sasatomi Toshimi Satoh Osamu Tokunaga Kohji Miyazaki

Expression of hepatocyte growth factor (HGF) and c-Met (HGF receptor) has been reported in many neoplasms. We investigated coexpression of HGF and c-Met to determine the role of the HGF/c-Met pathway in breast carcinoma, especially at the cancer front. Eighty-eight cases of carcinoma of the breast were studied by immunohistochemistry and by in situ hybridization for HGF and c-Met expression. The staining pattern was termed "front accentuation pattern" when it was most conspicuous at the cancer front. HGF and c-Met proteins were expressed in cancer and stromal cells, with autocrine and paracrine patterns. The front accentuation pattern of c-Met was observed in cancer cells, but not in stromal cells. The front accentuation pattern was not observed in HGF. Coexpression of HGF and c-Met at the cancer front was correlated with histologic grade, reduced patient survival and a high Ki-67 labeling index. Our findings suggest that the HGF/c-Met pathway acts primarily as a mitogen, especially at the cancer front, in a paracrine manner and affects some clinical factors, including patient survival.

10.1046/j.1440-1827.2001.01182.x

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Citations (124)

Relationship between prognosis of gallbladder carcinoma patients and the expression of E-cadherin/.ALPHA.-catenin.

The Japanese Journal of Gastroenterological Surgery (2000)

M. Mori Kohji Miyazaki Kenji Kitahara Shinsuke Mukai Kentaro Motomaya

胆嚢癌切除32例を対象として, 細胞間接着因子であるE型カドヘリンとその膜裏打ち蛋白質の一つであるαカテニンの免疫組織染色を行い, その発現性と深達度, 分化度, n, ly, v, pn, 予後との相関を検討した. 癌組織において, E型カドヘリン, αカテニンがいずれも正発現は5例 (15.6%) で, 深達度ssまで, n, ly, v, pnはすべて陰性で, これらの5年生存率は100%であった. 一方, いずれかが減弱・消失15例 (46.9%), いずれも減弱・消失12例 (37.5%) では, 分化度が低い深達度se, si癌の占める割合が多かった (51.9%). n, ly, v, pnの陽性率はおのおの43.8%, 59.4%, 25.0%, 37.5%と高率であり, おのおのの5年生存率は33.9%, 19.0%と有意に予後は不良であった. 以上より, E型カドヘリン, αカテニンの発現減弱は癌浸潤程度と相関しさらには予後の予測が可能で, 今後胆嚢癌の予後因子として有用であることが示唆された.

Alpha (finance)

10.5833/jjgs.33.584

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Citations (6)

Localization of vascular endothelial growth factor in synovial membrane mast cells: examination with ”multi-labelling subtraction immunostaining"

Virchows Archiv (1998)

Takahiro Yamada Motohiro Sawatsubashi Yumi Itoh Genichiro Edakuni M. Mori

Immunostaining

Pannus

10.1007/s004280050290

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Citations (34)

Fibroadenoma of the gallbladder with borderline malignancy: a poorly recognized gallbladder tumor

Journal of Hepato-Biliary-Pancreatic Surgery (2009)

Shinichiro Magata Keita Kai M. Mori Genichiro Edakuni Osamu Tokunaga

Carcinosarcoma

10.1007/s00534-009-0080-z

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Citations (3)

Arm span–height difference is correlated with gastroesophageal reflux symptoms in aged Japanese subjects

Journal of Clinical Biochemistry and Nutrition (2012)

Hitoshi Eguchi Yuichiro Eguchi M Fujiwara Midori Nishii Yoshinori Tokushima

Previous studies have indicated an association between the symptoms of gastroesophageal reflux disease (GERD) and aging plus height. In this study we investigated whether the arm span–height difference was related to GERD symptoms with a focus on aged subjects in the general population, since the arm span reflects the height in young adulthood before decreasing due to vertebral deformities from aging. A total of 285 elderly individuals (105 females) who visited nursing homes for the elderly in Japan were enrolled in this study. The GERD symptoms were evaluated by the Frequency Scale for the Symptoms of GERD (FSSG). The body weight, height and arm span were measured, and information regarding medications and complications were reviewed in each nursing record. 50.5% of women had more than 3 cm of arm span–height difference. In contrast, only 37.3% of men had more than 3 cm of arm span–height difference. The FSSG scores indicated more than 70% of subjects complained of any GERD symptoms. There was a significant correlation between the FSSG score and the arm span–height difference in the subjects with more than 3 cm of arm span-height difference (r = 0.236; p = 0.012). The correlation between the arm span–height difference and the FSSG score was significant only in women in females in the present study. In conclusion, our findings indicate that vertebral deformity evaluated by the arm span–height difference might have some positive relationship to the pathogenesis of GERD symptoms in elderly Japanese individuals.

10.3164/jcbn.12-89

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A CASE OF PULMONARY DIROFILARIASIS SUSPECTING OF LUNG CANCER

The journal of the Japanese Practical Surgeon Society (1993)

Genichiro Edakuni Keiichi Horita Tsuyoshi Ito

We experienced a case of pulmonary dirofirariasis which was first diagnosed by operation, because a possibility of lung cancer could not be denied for enlarging tendency of a tumor shadow on chest X-ray films. An 80-year-old woman was pointed out having an abnormal shadow in the lung field on a simple chest X-ray film, and was referred to the hospital. Chest CT scan revealed a mass with a diameter of 2.5cm on the right upperlobes S2. Right upperlobectomy was done, since lung cancer was suspected due to an increasing coinlesion on the simple chest X-ray film and definitediagnosis was not possible by bronchofiberscopy examination and needle biopsy. The parasite was confirmed by extracting specimen, and tomography, a diagnosis of pulmonary dirofilariasis being made. Recentry, pulmonary dirofilariasis, which is a type of zoonosis, is increasingly seen in the literature. When a coin lesions is seen on a simple chest X-ray film, we should entertain a possive occurrence of pulmonary dirofilariasis.

Dirofilariasis

10.3919/ringe1963.54.2566

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