Hypogonadism is highly prevalent in men older than 45 years and is associated with an increased risk of chronic diseases, including obesity, metabolic syndrome, diabetes, and cardiovascular disease. The objective of this study was to determine whether lifestyle factors such as smoking, diet, and exercise are associated with reduced testosterone levels.In this cross-sectional study, 147 men older than 44 years were recruited from a collaborative network of primary care clinics in the Dallas/Fort Worth, Texas, metropolitan area. Free testosterone levels were measured in plasma samples via an enzyme-linked immunosorbent assay-based method, and analyzed by simple and multiple linear regression in relationship to age, race/ethnicity, smoking, diet, exercise, obesity, diabetes, hypertension, and dyslipidemia.The participants had a mean free testosterone level of 3.1 ng/mL (standard deviation [SD] = 1.5) and mean age of 56.8 years (SD = 7.9). In simple regression analysis, free testosterone levels were associated with increased age (β = -0.04; P = .02), diet (β = -0.49; P = .05), diabetes (β = -0.9; P = .003), and hypertension (β = -0.55; P = .03) but not with race/ethnicity, smoking, exercise, obesity, or dyslipidemia. In multiple regression analysis, free testosterone values were significantly associated only with age (β = -0.05; P = .01) and diet (β = -0.72; P = .01).This study implicates diet, in addition to advanced age as a possible risk factor in the development of reduced testosterone levels.

Dyslipidemia

Free testosterone

10.1177/2150131913520234

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Citations (7)

[Glucosephosphate isomerase, a diagnostic criterium in psoriasis vulgaris?].

PubMed (1972)

Jason M. Meyer U. Kleeberg

Source

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Bacterial Conjugation

Springer eBooks (2008)

Colin Berry Jason M. Meyer Marjorie A. Hoy John B. Heppner William Tinzaara

10.1007/978-1-4020-6359-6_211

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Broad-Headed Bugs

Springer eBooks (2008)

Colin Berry Jason M. Meyer Marjorie A. Hoy John B. Heppner William Tinzaara

10.1007/978-1-4020-6359-6_10441

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Re-invigorating the insecticide discovery pipeline for vector control: GPCRs as targets for the identification of next gen insecticides

Pesticide Biochemistry and Physiology (2013)

Catherine A. Hill Jason M. Meyer Karin F.K. Ejendal Diego F. Echeverry Emma G. Lang

Ixodes scapularis

10.1016/j.pestbp.2013.02.008

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Citations (31)

Brood

Springer eBooks (2008)

Colin Berry Jason M. Meyer Marjorie A. Hoy John B. Heppner William Tinzaara

10.1007/978-1-4020-6359-6_10449

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Recombinant PNPLA1 catalyzes the synthesis of acylceramides and acyl acids with selective incorporation of linoleic acid

Journal of Lipid Research (2023)

Jason M. Meyer William E. Boeglin Alan Brash

Loss-of-function mutations in patatin-like phospholipase domain-containing protein 1 (PNPLA1) cause autosomal recessive congenital ichthyosis, and altered PNPLA1 activity is implicated in the pathogenesis of atopic dermatitis and other common skin diseases. To examine the hypothesis that PNPLA1 catalyzes the synthesis of acylceramides and acyl acids, we expressed and partially purified a soluble, truncated form of PNPLA1 in Escherichia coli, (PNPLA1

Adipose triglyceride lipase

10.1016/j.jlr.2023.100379

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Bates, Henry Walter

Springer eBooks (2008)

Colin Berry Jason M. Meyer Marjorie A. Hoy John B. Heppner William Tinzaara

BATES

10.1007/978-1-4020-6359-6_244

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