To analyze the seroepidemiological characteristics of hepatitis B virus (HBV) infection among adolescents aged 0-14 years in Henan Province and to evaluate the effectiveness of the childhood hepatitis B vaccine (HepB) immunization program.
To study the effects of indomethacin on interleukin-6 (IL-6) expression stimulated with lipopolysaccharide (LPS) in rheumatoid arthritic patients' synoviocyte.Fibroblast-like cells (FLS) from rheumatoid arthritic patients' joint tissue were cultured for 24 h and incubated 24 h with LPS (1 mg.L-1) or the supernatant of U937 cells stimulated by LPS (1 mg.L-1). After indomethacin or dexamethasone added into the supernatant of U937 cells, FLS was incubated with the super natant for 24 h. The expression of IL-6 protein was detected by radioimmunoassay. The mRNA expression of IL-6 was accessed by RT-PCR.LPS did not obviously affect the growth of FLS, and the protein secretion and mRNA expression of IL-6 were not changed in FLS treated with LPS. The IL-6 secretion and IL-6 mRNA expression were significantly increased in FLS cultured with the supernatant from U937 cell treated with LPS. Indomethacin at concentrations of 1 x 10(-7)-1 x 10(-5) mol.L-1 obviously inhibited the protein secretion and mRNA expression of IL-6 in FLS cultured with the supernatant from U937 cell stimulated with LPS, and the inhibitory effects increased as the concentrations of indomethacin increased.Indomethacin can inhibit the increase of IL-6 expression caused by supernatant of U937 cells stimulated with LPS in FLS.
To investigate the efficacy of phenobarbital (PB), factors associated with it, reasons for early treatment termination, and mortality rates in adult women living in rural Northeast China.A prospective study was conducted in seven counties of Jilin Province from 2010 to 2020. Adult women diagnosed with convulsive epilepsy were recruited into the study and baseline demographics recorded upon enrollment. Seizure frequency, prescribed drug dose, and adverse reactions were monitored monthly by door-to-door survey or telephone interview.A total of 1,333 women were included in the study. During the follow-up period, 169 participants (12.7%) were lost to follow-up, and 100 of them (7.5%) died. The percentage of seizure-free participants was 45.3% in the first year, 74.6% in the third year, and 96.6% in the 10th year. A higher baseline seizure frequency (OR = 1.005, 95% CI: 1.002-1.009), more frequent loss-of-consciousness seizures (OR = 1.620, 95% CI: 1.318-1.990), a higher daily dose of PB in the first year (OR = 1.018, 95% CI: 1.014-1.022), a younger age at onset (OR = 0.990, 95% CI: 0.982-0.998), and more severe drowsiness (OR = 1.727, 95% CI: 1.374-2.173) were associated with an increased risk of seizures in the first year, and the higher baseline seizure frequency was still associated with the occurrence of seizures in the third (OR = 1.007, 95% CI: 1.004-1.010) and fifth year (OR = 1.005, 95% CI: 1.002-1.008). Age at enrollment (HR = 0.983, 95% CI: 0.971-0.994) was the only factor that correlated with withdrawal from the study and with the death of the participant during the follow up period, but the correlation in each case was in opposite directions.PB has high effectiveness, retention rate, mild side effects, and tolerability when used as a treatment for epilepsy in women from rural areas. Baseline seizure frequency is an important predictor of prognosis regardless of treatment duration. PB is still a valuable tool for the management of epilepsy in adult women from poverty-stricken areas.
Menstruation is a recent topic around the influence of this particular period that most biological females need to experience in more than half of life.Although there are many studies of menstruation in biology and medicine, there are few studies based on the perspective of sociology, especially in Canada.As a developed country, Canada has already introduced laws about menstruation, but there are still social issues around menstruation for females.This study discusses the sociological influence of menstruation on feminism and symbolism.This study reviews recent research on the field of menstrual culture in sociology and mainly focuses on sociological studies in Canada.The stigma of menstruation deteriorates the mystery of menstruation and causes feelings of shame and fear among biological females.Some females do not know how they should behave during menstruation, and some males are biased toward menstruation because of insufficient education on it.Society's labels for menstruation are often negative and treat menstruation as a tool for human breeding, which leads females to selfobjectify themselves.Canada has introduced the Excise Tax Act; nevertheless, the sanitation supplies for menstruation are still expensive, causing period poverty.
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