SHUN MATSUKI

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Effects of Low Salt Plus Upright Posture, Angiotensin II, ACTH, and Potassium upon Plasma Renin Activity, Aldosterone, and Cortisol

Folia Endocrinologica Japonica (1975)

Takao Saruta Kazuoki Kondo Ikuo Saito Jiro MISUMI Ryuichi Nakamura

In order to study the control system of plasma aldosterone in human, we examined the effects of low salt plus upright posture, angiotensin II, ACTH and potassium upon plasma renin activity, aldosterone and cortisol in five subjects who were supposed to be normal. All of the procedures, low salt diet with below 3 g of salt and 2 hr-upright posture, 0.25 mg of Cortrosyn, angiotensin infusion to increase 20 mmHg of diastolic pressure for an hour, and 30 mEq of potassium infusion stimulated plasma aldosterone significantly. Furthermore, in each subject the degrees of response to each of these stimulations were almost same.In an old woman aged 68, responses to all of stimulations were significantly lower than those in other subjects.Plasma cortisol was significantly stimulated by ACTH, but slightly reduced by potassium infusion. From these results, it is certain that plasma aldosteron levels are easily affected by a small amount of changes in angiotensin, ACTH, potassium and sodium. However, responses of aldosterone to these changes seem to be decreased in old subjects.

Plasma renin activity

10.1507/endocrine1927.51.9_740

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[Obesity and hypertension].

PubMed (1984)

SHUN MATSUKI

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[Clinical experience with oxendolone for treatment of benign prostatic hyperplasia. Clinical efficacy and effects on serum lipid and lipoprotein fraction levels].

PubMed (1984)

Akhuro Yasukawa Hiroshi Nihira SHUN MATSUKI Masanori Fujii Hironobu Fujiwara

Forty-three patients with benign prostatic hyperplasia were treated with weekly i.m. injections of 400 mg oxendolone for 12 weeks. The subjective symptoms were improved in 83% of these patients. Residual urine was decreased significantly and Qmax was increased by this treatment. Serum VLDL level was suppressed significantly, whereas the levels of LDL, total cholesterol, HDL-cholesterol and triglycerides were changed little. Atherosclerotic index and the ratio of (total cholesterol--HDL-cholesterol) to (HDL-cholesterol), was not influenced by the treatment. No severe side-effect was found. These findings suggest that oxendolone is the drug of choice for non-surgical treatment of benign prostatic hyperplasia.

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HGH RESPONSE TO INSULIN-INDUCED HYPOGLYCEMIA IN HEALTHY AND OBESE SUBJECTS

The Keio Journal of Medicine (1973)

Yutaka Suzuki Hiroshi Maruyama YOICHI TAKABAYASHI H. Sohara H Atsuji

Insulin response

10.2302/kjm.22.1

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Effects of furosemide and chlorothiazide on blood pressure and plasma renin activity

Cardiovascular Research (1976)

Isao Saito Jiro Misumi Kiyosi Kondô T Saruta SHUN MATSUKI

Short (2 weeks) and long (12 weeks) term effects of furosemide and chlorothiazide on blood pressure, plasma renin activity, and uric acid concentration were studied in 69 hypertensive patients. Both treatments caused significant reductions in blood pressure and increases in plasma renin activity and uric acid at 2 and 12 weeks in 6) normal renin patients; there was no difference between the effects of furosemide and that of chlorothiazide. Reduction in blood pressure in eight low renin patients who showed smaller changes in plasma renin activity and uric acid was not significant at 2 weeks but significant after 12 weeks of treatment.

Chlorothiazide

Plasma renin activity

10.1093/cvr/10.2.149

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L BENCE JONES TYPE MULTIPLE MYELOMA ASSOCIATED WITH AMYLOIDOSIS AND ILEUS: A CASE REPORT

Nihon Naika Gakkai Zasshi (1973)

Yasuo Ikeda Keisuke Toyama SHUN MATSUKI Seiichi Asano Motohiko Aiba

74才,女性.全身倦怠感,肩の痛みを主訴として来院.入院時,著明な貧血,異型性ある骨髄形質細胞の増加,尿中L Bence-Jones蛋白,骨破壊,著しい腎機能障害を認めた. L Bence-Jones型骨髄腫による腎不全として経過観察中,便秘,嘔吐,腹部膨満が出現.腹部単純X線像,注腸透視より閉塞性イレウスの併発が考えられた.全身状態は悪化し,回腸瘻造設術を施行するも効果なく,腎不全は進行し,気管支肺炎を合併して死亡した.剖検にて全消化管の固有筋層内にアミロイドの著しい沈着を認め,これがイレウスの原因と思われた.アミロイドはその他,舌,心,肺,腎,骨格筋にみられたが,とくに腎尿細管円柱中にアミロイドがみられたことは興味深い.アミロイドーシスの消化器症状を中心に,イレウス発現の機序についての文献的考察を行ない,さらにアミロイドーシスと骨髄腫との関係についても言及した.

Bence Jones protein

10.2169/naika.62.274

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An Evidence for the Decrease of Body Muscle Mass Due to Thyrotoxicosis and Long Term Steroid Therapy by Means of Height, Weight and Upper Arm Circumference Measurements

Endocrinologia Japonica (1972)

SHUN MATSUKI Ryuya Yoda Naoko Momotani

A weight-corrected UAC of 109 males and 292 females with untreated thyrotoxicosis was compared with that of the same number of control subjects. Control subjects were chosen from the subjects without apparent diseases; one control for one patient with about the same age, height and weight. The mean value of the weight-corrected UAC in thyrotoxic patients was 25.4cm both in males and females. The mean value of the controls was 26.7cm in males and 26.0cm in females. These findings suggest that UAC of thyrotoxic patients is smaller than that of controls even in the same height and weight, and that there is a significant decrease of body muscle mass in thyrotoxic patients.Furthermore, it was suggested that the body muscle mass was decreased in 4 cases which had a long term steroid therapy, because the weight-corrected UAC was smaller than that of the controls.

Circumference

10.1507/endocrj1954.19.407

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Enhanced plasma insulin response to L-Leucine load and its diminution after weight reduction

International Journal of Obesity (1978)

Kensuke Kataoka Atsushi Suzuki Yasuhiro Suzuki SHUN MATSUKI

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Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics (1982)

Tadashi Okabe Susumu Ishizawa Kunizo Kataoka SHUN MATSUKI

老年者の赤血球パラメーターの加齢に伴う変化を, 健康男子102名を対象に20歳代から70歳代まで各年代別に比較検討し, その加齢変化とビタミンB12, 葉酸との関係を, deoxyuridine suppresion test を用いて検討し, 次の成績を得た.1. 赤血球パラメーターのうち, 赤血球数, Hb量は, 20歳代から60歳代までは有意差がなく, 70歳代で初めて有意の低下を示した. MCV. MCHは, 70歳以降に明らかに増加する傾向が見られた. MCHCには, 加齢に伴う変化を認めなかった.2. deoxyuridine suppression test は, 若年者群10名, 老年者群10名の全例とも正常を示した. すなわち, 正常老年者の骨髄細胞では DNA-thymine 合成系におけるdU→dTMPの変換に障害はなく, ビタミンB12, 葉酸の欠乏は認められなかった.以上の成績より, 正常老年者の赤血球パラメーターは, 70歳以降, 軽度に大球性貧血類似の変化を示したが, その発現機序にはビタミンB12, 葉酸欠乏は関与せず, 他の原因が考えられた.尚, 我々は deoxyuridine suppression test を, multiple automatic cell harvester を用いることにより簡略化したが, 今までの方法と比較すると, 少量の骨髄サンプルで所要時間も大幅に短縮された. 今後, 臨床的に巨赤芽球性貧血の確定診断に有用な方法と考えられる.

Deoxyuridine

Thymine

10.3143/geriatrics.19.531

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Insulin Like Action of Oxytocin

Folia Endocrinologica Japonica (1985)

Tadashi Okabe Kazuhiro Hosokawa Kunizo Kataoka SHUN MATSUKI

The insulin-like activity of oxytocin in stimulating glucose oxidation in rat adipocytes has been demonstrated repeatedly in the last 20 years. Oxytocin binds to a specific cell surface receptor of adipocytes; however, little attention has yet been paid to the effect of oxytocin on glucose oxidation in other tissues. We have initiated studies into the metabolic-regulatory activity of oxytocin in insulin sensitive tissues and uterus.

10.1507/endocrine1927.61.10_1197

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