The use of glycerolates of biogenic elements as biocompatible precursors in sol–gel synthesis is an innovative direction and opens up new scientific and practical prospects in chemistry and technology of producing practically important biomedical materials, including hemostatic, antimicrobial, and wound healing materials. Using biocompatible precursors, silicon, zinc, boron, and iron glycerolates, new bioactive nanocomposite hydrogels were obtained by the sol–gel method. The composition and structural features of the hydrogels were studied using a complex of modern analytical techniques, including TEM, XRD, AES, and ESI MS. Hemostatic activity of the hydrogels was studied in the in vivo experiments; using the example of silicon-iron-zinc-boron glycerolates hydrogel, primary toxicological studies were carried out. Antimicrobial properties of hydrogels were studied using the agar diffusion method. The structural features of hydrogels and their relationship to medical and biological properties were revealed. It was shown that glycerolates hydrogels are non-toxic, and exhibit pronounced hemostatic activity, generally comparable to the commercial hemostatic drug Capramine. Antimicrobial activity is more pronounced for silicon-iron-zinc-boron and silicon-iron-boron glycerolates gel. The results obtained indicate that these glycerolates hydrogels are potential hemostatic and antibiotic-independent antimicrobial agents for topical wound healing applications in medical and veterinary practice.

Hemostatic Agent

10.3390/gels10120795

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Синтез, токсичность и трансдермальная проницаемость глицератов кремния и гидрогелей на их основе

Химико-фармацевтический журнал (2008)

Т. Г. Хонина О. Н. Чупахин Л. П. Ларионов Т. Г. Бояковская А. Л. Суворов

Silicon glycerolates of the general formula Si(C3H7O3)4 ⋅ xC3H8O3 (3 ≤ х ≤ 10) and related hydrogels of the general formula Si(C3H7O3)4 ⋅ xC3H8O3 ⋅ yH2O (3 ≤ x < 10, 20 < y ≤ 40) were synthesized and some their pharmacological properties were studied. The laws of gel formation were investigated and optimum conditions for the process were determined. High percutaneous (transdermal) activity of the synthesized compounds was revealed by measuring the diffusion of drugs through the intact skin membrane in vitro. The acute and chronic toxicity was studied and was established that all substances are nontoxic. The experimental results show that silicon glycerolates and related hydrogels can be recommended for further testing and investigation as effective biologically active percutaneous vehicles of medicinal preparations.

10.30906/0023-1134-2008-42-11-5-9

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Silicon–boron-containing glycerohydrogel having wound healing, regenerative, and antimicrobial activity

Russian Chemical Bulletin (2017)

О. Н. Чупахин Т. Г. Хонина Nikolay V. Kungurov Н. В. Зильберберг Н. П. Евстигнеева

10.1007/s11172-017-1771-2

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Features of formation and structure of silicon–polysaccharide-containing polyolate hydrogels obtained by the method of biomimetic mineralization

Journal of Sol-Gel Science and Technology (2019)

М. В. Иваненко Elena Yu. Nikitina Т. Г. Хонина Е. В. Шадрина Maria E. Novoselova