David W. Frank

University of Georgia

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Dean Sabatinelli

University of Georgia

Francesco Versace

The University of Texas MD Anderson Cancer Center

Elise M. Stevens

University of Massachusetts Chan Medical School

Menton M. Deweese

Vanderbilt University

Jason D. Robinson

The University of Texas MD Anderson Cancer Center

Susan M. Schembre

Georgetown University Medical Center

Paul M. Cinciripini

The University of Texas MD Anderson Cancer Center

Damon J. Vidrine

Moffitt Cancer Center

Rachel F. Tyndale

University of Toronto

Megan M. Filkowski

National Institute of Neurological Disorders and Stroke

Cooperative Institutions

The University of Texas MD Anderson Cancer Center

University of Georgia

The University of Texas Health Science Center at Houston

University of Florida

University of California, San Diego

Central Michigan University

Emory University

Harvard University

University of Oklahoma Health Sciences Center

Pfizer (United States)

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Affective modulation of scene perception

David W. Frank

Modulation (music)

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A Neurophysiological Measure of Reward Sensitivity and its Limited Association with Anhedonia in Adolescents and Young Adults

bioRxiv (Cold Spring Harbor Laboratory) (2018)

David W. Frank Elise M. Stevens Francesco Versace

Abstract Anhedonia (i.e., the attenuated ability to enjoy pleasurable stimuli) characterizes multiple mood disorders, but its neurophysiological underpinnings are not yet clear. Here, we measured event-related potentials in 116 adolescents and young adults engaged in a signal detection task designed to objectively characterize the anhedonic phenotype. In line with previous studies, the behavioral results showed that approximately 35% of the sample did not develop a response bias towards the more frequently rewarded stimuli (a sign of low hedonic capacity). The event-related potentials (ERPs) evoked by the reward feedback stimuli delivered during the task showed that individuals that did not develop a response bias had significantly less cortical positivity at Fz from 224 ms to 316 ms post feedback onset compared to those that developed a response bias during the task. However, further analyses showed that this between groups difference was relatively weak, as it disappeared when we controlled for response-locked ERPs. Furthermore, the response bias observed in the signal detection task was not strongly associated with self-reported ratings of hedonic capacity. We conclude that even though the signal detection task may be used as a reward sensitivity measure in neurotypical adolescents and young adults, this task may only be able to detect clinically significant levels of anhedonia in this particular population.

Anhedonia

Neurophysiology

Association (psychology)

Response bias

Neurotypical

10.1101/467217

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A neurophysiological measure of reward sensitivity and its association with anhedonia in psychiatrically healthy adolescents and young adults

International Journal of Psychophysiology (2019)

David W. Frank Elise M. Stevens Francesco Versace

Anhedonia

Association (psychology)

Neurophysiology

10.1016/j.ijpsycho.2019.05.002

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Citations (2)

Abetting Mass Prison Escape: A Defense

David W. Frank

Because the United States government will neither immediately protect nor immediately release its prisoners under threat of harm, others must act. These other individuals, defined by law as “rescuers,” would be those who both free prisoners and accept legal responsibility for the necessary acts of deliverance. Fortunately, rescuers may raise the defense of third-party duress if prosecuted for freeing prisoners. Rescuers can, and should, use this as a defense to their alleged crimes — and should also use it deliver the whole of the U.S. penal population from captivity. In this article, I present my argument for this position.First, I show that the nature of violence permeating the U.S. penal system allows rescuers to presume all prisoners are under imminent threat of danger. Next, I note that while duress as a defense is available to prison escapees, courts rarely allow or consider it, and are unlikely to change their position. Third, I argue that because all prison escapees are entitled to the duress defense, the weight of law permits and should be more widely recognized as permitting, the defense of third-party duress for the act of rescue and any assistance that aids and abets escape. Finally, I conclude with the suggestion that the state of the U.S. penal system places a moral responsibility on non-prisoners to rescue those in captivity.

Argument (complex analysis)

Position (finance)

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Emotion regulation: Quantitative meta-analysis of functional activation and deactivation

Neuroscience & Biobehavioral Reviews (2014)

David W. Frank M. Ross DeWitt Matthew E. Hudgens‐Haney David J. Schaeffer B. Hunter Ball

Parahippocampal gyrus

10.1016/j.neubiorev.2014.06.010

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Citations (398)

Primate Visual Perception: Motivated Attention in Naturalistic Scenes

Frontiers in Psychology (2017)

David W. Frank Dean Sabatinelli

Research has consistently revealed enhanced receptive field activation corresponding to attended cues coupled with suppression to unattended cues. This attention effect depends both on the spatial features of stimuli and internal task goals. However, a large majority of research supporting this effect involves circumscribed tasks that possess few ecologically relevant characteristics. By comparison, natural scenes have the potential to engage an evolved attention system, which may be characterized by features that are distinct from those engaged by reduced experimental paradigms. Here we describe recent animal and human studies of naturalistic scene viewing to highlight the specific impact of social and affective processes on the neural mechanisms of attention modulation.

Naturalism

10.3389/fpsyg.2017.00226

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Citations (17)

Hemodynamic and electrocortical reactivity to specific scene contents in emotional perception

Psychophysiology (2019)

David W. Frank Dean Sabatinelli

Abstract Emotional scene perception is characterized by enhanced neural activity across broad regions of visual cortex, the frontoparietal network, and anterior corticolimbic structures. In human fMRI and electrocortical experiments, activation enhancement is strongly related to self‐reported emotional arousal evoked by scene stimuli. However, an additional bias in reaction to pleasant scenes has been reported in a subset of emotion‐enhanced brain regions. Human fMRI and primate electrophysiological studies show biased frontoparietal network activity in response to rewarding cues. In addition, activation in lateral occipital regions may show a bias in pleasant scene perception, as shown in fMRI and in the early posterior negativity (EPN) ERP component. To define this potential pleasure bias, we presented a balanced set of naturalistic scenes to participants during separate fMRI and ERP recording sessions. Consistent with past work, the amplitude of the slow‐wave late positive potential (LPP), as well as hemodynamic activity in fusiform gyrus and amygdala, showed equivalent enhancement across highly arousing pleasant and unpleasant, relative to neutral scenes. In addition to this emotional enhancement, the EPN component, as well as hemodynamic activity in lateral occipital cortex and frontoparietal network, showed greater reactivity during highly arousing pleasant relative to unpleasant scenes, consistent with a pleasure bias. The interpretation of this pattern of reactivity is discussed with respect to selective and evolved attention mechanisms.

Fusiform gyrus

Occipital lobe

Brain mapping

Blood-oxygen-level dependent

Reactivity

10.1111/psyp.13340

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Citations (27)

P3a from white noise

International Journal of Psychophysiology (2012)

David W. Frank Ryan B. Yee John Polich

P3a