Tingting Xiao

Institute of Solid State Physics

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Lijian Xie

Jinshan Hospital of Fudan University

Yonghong Xiao

State Key Laboratory of Diagnosis and Treatment of Infectious Diseases

Yanzi Zhou

Nanjing University

Ping Shen

Zhejiang University

Cuilan Hou

Shanghai Children's Hospital

Min Huang

Mount Sinai Health System

Beisha Tang

Xiangya Hospital Central South University

Bin Jiao

Central South University

Lu Shen

Xiangya Hospital Central South University

Kai Zhou

Chinese Academy of Fishery Sciences

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Shanghai Jiao Tong University

122

Zhejiang University

Chinese Academy of Sciences

Peking University

Central South University

Shanghai Children's Hospital

Wuhan University

State Key Laboratory of Diagnosis and Treatment of Infectious Diseases

First Affiliated Hospital Zhejiang University

Fujian Medical University

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A retrospective analysis of Pseudomonas aeruginosa bloodstream infections: prevalence, risk factors, and outcome in carbapenem-susceptible and -non-susceptible infections

Antimicrobial Resistance and Infection Control (2019)

Qingyi Shi Chen Huang Tingting Xiao Zhenzhu Wu Yonghong Xiao

Pseudomonas aeruginosa (PA) is a leading cause of nosocomial infections, and carbapenem non-susceptible strains are a major threat to patient safety.A single center, retrospective comparative analysis of carbapenem-non-susceptible PA (CnSPA) and carbapenem-susceptible PA (CSPA) bloodstream infections (BSIs) was conducted between January 1, 2007, and December 31, 2016. Prevalence and risk factors associated with CnSPA BSIs were examined.The study enrolled 340 patients with PA BSIs; 30.0% (N = 101) of patients had CnSPA. High APACHE II scores (≥15), central venous catheterization, and delayed application of appropriate definitive therapy were independently associated with higher risk of mortality in PA BSIs. Multivariate analysis revealed that respiratory disease and exposure to carbapenems within the previous 90 days to onset of BSI were independent risk factors for acquisition of CnSPA BSIs. Overall all-cause 30-day mortality associated with PA BSIs was 26.8% (91/340). In addition, mortality was higher in patients with CnSPA than in those with CSPA (37.6% vs. 22.2%, respectively; P = 0.003). Corticosteroid therapy and delayed receipt of effective definitive therapy were independent risk factors for death from CnSPA BSIs.Increased incidence of CnSPA BSIs was observed during the study period, with higher mortality seen in patients with these infections. Respiratory disease and exposure to carbapenems were independent risk factors for development of CnSPA BSIs. Appropriate definitive therapy reduced mortality rates. BLBLIs were as effective as carbapenems as a treatment for PA BSIs.

Carbapenem

Medical microbiology

10.1186/s13756-019-0520-8

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Citations (56)

Research on Orderly Charging Strategy of Electric Vehicles Considering Uncertainties of User Behavior

2020 7th International Forum on Electrical Engineering and Automation (IFEEA) (2023)

Tingting Xiao Yonggang Peng

Under the requirement of environmental protection, electric vehicles (EVs) are becoming widely used and connected to the power grid on a large scale. Meanwhile, the disorderly EV charging behavior will cause a plethora of challenges for the power system. In other words, the capacity planning of the power grid cannot meet the charging demand of EVs on a large scale, especially for the penetration of fast chargers. In this paper, an orderly charging strategy is proposed based on the transformer power margin. Specifically, a targeted charging pricing mechanism is designed to guide the charging behavior of fast and slow chargers based on the difference in charging power. Moreover, the Monte Carlo simulation is adopted to obtain the randomness of EV owners' travel behavior. Finally, the proposed EV charging optimization scheme is solved by the particle swarm optimization method. The case study shows that the proposed orderly charging strategy can effectively alleviate the transformer burden, which provides references for EV charging orderly.

10.1109/ifeea60725.2023.10429165

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[Laparoscopic management of persistent Müllerian duct syndrome: A case report and pedigree investigation].

PubMed (2021)

Xiaofan Liu Weiqing Wu Guoqing Dong Tingting Xiao Yang Liu

To investigate the clinical characteristics, diagnosis, treatment and etiology of persistent Müllerian duct syndrome (PMDS).A 3-year-old boy was diagnosed with PMDS according to the clinical manifestations and the results of ultrasonography, laboratory examinations and earlier surgical examination. We performed genetic tests for the patient and his family members, removed the infantile uterus by laparoscopic wedge hysterectomy, biopsied and descended the bilateral testes, and ligated the bilateral internal rings, followed by a retrospective analysis and review of relevant literature.The operation was successful. Gonad biopsy revealed testis tissue, and PMDS was confirmed by intraoperative findings and related examinations. Good bilateral testicular blood supply was found during the 6-month follow-up after surgery. Medical exome sequencing showed the AMHR2 gene c.1499G > A (p.Cys500Tyr) mutant homozygote (A/A) in the patient and his sister and mutant heterozygote (G/A) in his parents.Laparoscopy is definitely effective for the treatment of PMDS. In surgery, the infantile uterus should be removed in case of good blood supply to the testis, and so were the bilateral testes if they cannot be descended. The homozygous mutation in the AMHR2 gene c. 1499G > A (p. Cys500Tyr) can lead to male PMDS. Pedigree investigation may provide some evidence for possible fertility in PMDS patients.

Etiology

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Mapping and identification of CsSF4, a gene encoding a UDP-N-acetyl glucosamine-peptide N-acetylglucosaminyltransferase required for fruit elongation in cucumber (Cucumis sativus L.)

Theoretical and Applied Genetics (2023)

Keyan Zhang Yao DanQing Yue Chen Haifan Wen Jian Pan

Cucumis

Silique

Ethyl methanesulfonate

10.1007/s00122-023-04246-9

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Citations (9)

Meta-analysis of risk factors associated with atherosclerosis in patients with Kawasaki disease

World Journal of Pediatrics (2016)

Han Zhang Mingguo Xu Lijian Xie Min Huang Jie Shen

10.1007/s12519-016-0023-0

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Single-cell analysis of peripheral blood mononuclear cells to reveal of cellular etiology of Kawasaki disease based on hygiene hypothesis

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Qiuping Lin Zhen Wang Guohui Ding Guang Li Liqin Chen

Abstract Background Kawasaki disease (KD) is an acute systemic vasculitis that can lead to acquired heart disease in children mostly from in developed countries. The previous research showed that B cells in KD patients underwent a profound change in both the cell numbers and types after intravenous immunoglobulin (IVIG) therapy. Methods We performed the single-cell RNA-sequencing for the peripheral blood mononuclear cells (PBMCs) from three febrile patients and three KD patients to investigate the possible mechanism underlying B cell developmental dysfunction in KD. A previously published single-cell sequencing KD dataset (GSE168732) was also utilized in study for sample size expansion and validation. The comprehensive single-cell data analyses were applied for our dataset and GSE168732 dataset including single-cell trajectory analysis. To validate the immune disorders in KD, we measured immune-related indicators from 28 KD and 28 febrile patients. Result Overall single-cell expression profiles show that the biological processes of immunity, B cell activation pathway and their related biological entities are repressed in KD patients before IVIG treatment compared to febrile patient and KD patients after IVIG treatment. The differentially expressed gene analyses further demonstrate that B cell signaling pathway is downregulated in B cells and plasma blast cells of KD patients before treatment while cell cycle genes and MYC gene are upregulated in dendritic cells (DCs) and hematopoietic stem and progenitor cells (HSPCs) of KD patients before treatment. The biological process of immune response is upregulated in the HSPCs of KD patients before treatment in our dataset while the biological process of inflammatory response is upregulated in the HSPCs of KD patients before treatment in GSE168732 dataset. Single-cell trajectory analyses demonstrate that KD patients before treatment have a shortened developmental path in which B cells and T cells are failed to differentiate into separate lineages. HSPD1 and HSPE1 genes show an elevated expression level in the early cell development stage of KD patients before treatment accompanied with the repression of MYC, SPI1, MT2A and UBE2C genes. Our analyses of all B cells from KD patients before treatment show most of B cells are arrested in a transitional state with an ill developmental path compared with febrile patients and KD patients after treatment. The percentage and absolute value of CD8 T cells in KD were lower than those in febrile patients. The ratio of CD4/CD8 in KD was higher than it in febrile patients. The serum levels of IgG and IgM in KD were lower than those in febrile patients. Conclusions Our results indicate that the immune premature HSPCs accompanied with the abnormal expression dynamics of cell cycle and SPI1 genes are the mechanism underlying B cell developmental dysfunction in KD patients. Funding This work is jointly supported by National Natural Science Foundation of China (82170518) and the Shanghai Science and Technology Committee research Funding (22Y11909700) and Shanghai Jinshan District medical key specialty Funding (JSZK2023A04).

Etiology

10.1101/2023.02.21.529340

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Torsades de Pointes electrical storm in children with KCNH2 mutations

BMC Medical Genomics (2024)

Li Zhang Meng Xu Zhen Yan Yan Han Xunwei Jiang

Congenital long QT syndrome (LQTS) is a genetic heart disorder, which may lead to life-threatening arrhythmias, especially in children. Here, we reported two children who were initially misdiagnosed with epilepsy and experienced Torsades de Pointes (TdP) cardiac electrical storm (ES). Through whole exome sequencing (WES), we identified two Potassium voltage-gated channel subfamily H member 2 (KCHN2) mutations (c.1841 C > T and c.1838 C > T) respectively in a 6-year-old boy and a 13-year-old girl. Clinical data indicated that the QT interval was significantly prolonged, the T-wave pattern of chest V5-V6 leads and limb leads were inverted. Our study suggests that patients with epilepsy, especially those refractory epilepsy with atypical features, need comprehensive evaluation of cardiovascular function. KCNH2 mutation in pore region, QT interval prolongation and T wave inversion are high risk factors for ES. For LQT2 patients with ES, Nadolol and left cardiac sympathetic denervation are indicated, sometimes with an ICD.

Torsades de pointes

Human genetics

10.1186/s12920-024-02025-z

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DYRK1A Interacts with the Tuberous Sclerosis Complex and Promotes mTORC1 Activity

Pinhua Wang Sunayana Sarkar Menghuan Zhang Tingting Xiao Fenhua Kong

DYRK1A, a ubiquitously expressed kinase, is linked to the dominant intellectual developmental disorder, microcephaly and Down syndrome in humans. It regulates numerous cellular processes such as cell cycle, vesicle trafficking and microtubule assembly. DYRK1A is a critical regulator of organ growth; however, how it regulates organ growth is not fully understood. Here, we show that the knockdown of DYRK1A results in reduced cell size, which depends on mTORC1. Using proteomic approaches, we found that DYRK1A interacts with the Tuberous sclerosis complex (TSC) proteins, namely TSC1 and TSC2, which negatively regulate mTORC1 activation. Further, we show that DYRK1A phosphorylates TSC2 at T1462, a modification known to inhibit TSC activity and promote mTORC1 activity. We also found that the reduced cell growth upon knockdown of DYRK1A can be rescued by overexpression of RHEB, an activator of mTORC1. Our findings suggest that DYRK1A inhibits TSC complex activity through inhibitory phosphorylation on TSC2, thereby promoting mTORC1 activity. Further, using the Drosophila neuromuscular junction as a model, we show that the mnb, the fly homologues of DYRK1A , is rescued by RHEB overexpression, suggesting a conserved role of DYRK1A in TORC1 regulation.

DYRK1A

TSC2

10.7554/elife.88318.2

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Citations (0)

SNTA1 altered reactive oxygen species production is associated with J wave syndromes

Gene Reports (2021)

Cuilan Hou Xiaomin Sun Xunwei Jiang Qingzhu Qiu Shun Chen

Sanger sequencing

Exome

10.1016/j.genrep.2021.101250

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The clinical features and prognosis of infective endocarditis in the elderly from 2007 to 2016 in a tertiary hospital in China

BMC Infectious Diseases (2019)

Zhenzhu Wu Yi Chen Tingting Xiao Tianshui Niu Qingyi Shi

Abstract Background Infective endocarditis (IE) especially in the elderly is a serious disease, with a worse prognosis. Methods A retrospective cohort study was conducted. A total of 405 patients with definite IE were divided into three groups: 205 patients under 50 years old, 141 patients between 50 and 64 years old and 59 patients over 65 years old. Results For older patients, clinical symptoms such as fever, anemia, and heart murmur were as common as the younger patients. IE in old patients had more frequent nosocomial origin ( P = 0.007) and tended to be more frequent with bad oral hygiene ( p = 0.008). The most frequent isolated pathogens in the old groups was streptococci and coagulase-negative staphylococci. The old patients had a lower operation rate (40.7% vs 58.9% vs 62.4%, P = 0.012) and higher in-hospital mortality (20.3% vs 10.6% vs 8.8%, P = 0.044) compared with the younger patients. Surgical treatment was a significant predictor of one-year mortality even after adjusting for the confounders (HR = 2.45, 95% CI 1.027–10.598, P = 0.009). The one-year survival rate was higher for older patients with surgical intervention than those without (95.8% vs 68.6%, P = 0.007). Conclusions Older patients with IE presented with more comorbidities, bad oral hygiene, more nosocomial origin and a more severe prognosis than younger patients. Streptococci was the most frequent micro-organisms in this group. Surgery were underused in old patients and those with surgical treatment had better prognosis.

Medical microbiology

Infective Endocarditis

10.1186/s12879-019-4546-6

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Citations (12)