Runhua Yang

State Key Laboratory of Stem Cell and Reproductive Biology

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Zhang Shao-gang

Nanjing University of Chinese Medicine

Rong Gao

Beijing Normal University

Sokol Kalaveshi

Baptist Hospital of Miami

Dongdong Hu

East China University of Science and Technology

Huatou Zhao

Gaochun People's Hospital

Xiao Tan

Second Affiliated Hospital of Nanjing Medical University

Zhengwei Chen

National University of Singapore

Wei Zhang

Nanjing University of Chinese Medicine

Xiaomin Cai

Nanjing General Hospital of Nanjing Military Command

Jiao Chen

Army Medical University

Cooperative Institutions

Nanjing Medical University

Nanjing University of Chinese Medicine

Nanjing University

Nanjing General Hospital of Nanjing Military Command

Jiangsu Province Hospital

Huazhong University of Science and Technology

Sun Yat-sen University

Chinese Academy of Sciences

Nantong University

Second Affiliated Hospital of Nanjing Medical University

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Early central nervous system development and neuron regeneration

Current Opinion in Genetics & Development (2024)

Runhua Yang Fen Ji Jianwei Jiao

10.1016/j.gde.2024.102286

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The influence of coronavirus disease 2019 on emergency department visits in Nanjing, China: A multicentre cross-sectional study

The American Journal of Emergency Medicine (2020)

Hao Sun Keqin Liu Meng Li Shaowen Tang Andrew A. Monte

Pandemic

Cross-sectional study

10.1016/j.ajem.2020.07.086

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Citations (12)

Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy

Inflammation (2016)

Rong Gao Mu‐Huo Ji Dapeng Gao Runhua Yang Zhang Shao-gang

neuregulin 1

10.1007/s10753-016-0484-2

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Citations (43)

Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

Inflammation (2015)

Rong Gao Ming-qiang Kan Wang Shi-gang Runhua Yang Zhang Shao-gang

Kynurenine pathway

Neurotoxicity

Indoleamine 2,3-dioxygenase

10.1007/s10753-015-0279-x

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Citations (33)

Hydroxytyrosol Protects against Myocardial Ischemia/Reperfusion Injury through a PI3K/Akt-Dependent Mechanism

Mediators of Inflammation (2016)

Yinghao Pei Jiao Chen Liang Xie Xiaomin Cai Runhua Yang

Objective . To investigate the effects and mechanisms of hydroxytyrosol (HT) during the pathogenesis of myocardial ischemia reperfusion (I/R) in rat hearts. Methods . The rats were randomized into five groups: sham group, I/R group, HT+I/R group, HT+LY294002+I/R group, and LY+I/R group. Myocardial infarct size, markers of oxidative stress, extent of myocardial apoptosis, echocardiographically assessed cardiac function, and expression of Akt and GSK 3 β were measured in each group. Results . Prereperfusion administration of HT was associated with a significantly smaller area of myocardial infarction and remarkably decreased level of myocardial apoptosis and necrosis, as evidenced by a lower apoptotic index, reduced cleaved caspase-3, and the serum activities of lactate dehydrogenase and creatinine kinase MB. Moreover, HT also attenuated the impairment of cardiac systolic function. However, cotreatment with LY294002 and HT completely abolished the above cardioprotective effects of HT. A subsequent mechanistic study revealed that the cardioprotective effects of HT during the process of I/R of the myocardium were dependent on the activation of the Akt/GSK3 β pathway. Conclusion . Pretreatment with HT may have antiapoptotic and cardioprotective effects against myocardial I/R injury, and these effects seem to be related to the activation of the Akt/GSK3 β pathway in the myocardium.

Cardioprotection

Hydroxytyrosol

LY294002

Pathogenesis

Creatine kinase

10.1155/2016/1232103

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Citations (40)

New-onset Atrial Fibrillation is Infrequent in Acute COVID-19 but Maybe Associated With Worse Outcomes

Circulation (2020)

Runhua Yang Sokol Kalaveshi David Goldgrab Jessica Craig Stephen Mester

2019-20 coronavirus outbreak

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Hippocampal β2‑microglobulin mediates sepsis‑induced cognitive impairment

Molecular Medicine Reports (2018)

Rong Gao Guomin Li Runhua Yang Hongmei Yuan Zhang Shao-gang

Acute brain dysfunction is a frequent complication in sepsis patients and is associated with long‑term neurocognitive consequences and increased mortality, yet the underlying mechanism remains unclear. Emerging evidence has suggested that β2‑microglobulin [a component of major histocompatibility complex (MHC) class I molecules] is involved in cognitive dysfunction in various neurological diseases. Therefore, the present study tested the hypothesis that β2‑microglobulin in the brain also mediates sepsis‑induced cognitive impairment. In the present study, wild‑type and antigen processing 1 (Tap1)‑deficient mice (Tap1‑/‑) were subjected to cecal ligation and puncture (CLP). Survival rate, cognitive function, and biochemical analysis were performed at the indicated time points. The data revealed that CLP induced anxiety‑like behavior and impaired hippocampal‑dependent contextual memory in wild‑type mice, which was accompanied by hippocampal microglial activation, increased level of interleukin‑1β, and decreased concentrations of brain derived neurotrophic factor and postsynaptic density protein 95. Notably, it was demonstrated that Tap1‑/‑ mice with reduced cell surface expression of MHC I protected mice from anxiety‑like behavior and impaired hippocampal‑dependent contextual memory and reversed most of these biochemical parameters following sepsis development. In summary, the results of the present study suggest that β2‑microglobulin negatively regulates cognitive impairment in an animal model of sepsis induced by CLP.

Neurocognitive

Cognitive Decline

10.3892/mmr.2018.8858

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Citations (5)