Agnieszka Trzcińska

National Institute of Public Health

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Joanna Siennicka

National Institute of Public Health

B Litwińska

National Institute of Public Health

Agnieszka Częścik

National Institute of Public Health

M Kańtoch

Wojskowy Instytut Higieny i Epidemiologii

Milena Dunal-Szczepaniak

National Institute of Public Health

Magdalena Rosińska

The Maria Sklodowska-Curie National Research Institute of Oncology

Magdalena Durlik

Medical University of Warsaw

Katarzyna Pancer

National Institute of Public Health

J Siennicka

Milena Dunal

Cooperative Institutions

National Institute of Public Health

Wojskowy Instytut Higieny i Epidemiologii

Medical University of Warsaw

Instytut Hematologii i Transfuzjologi

Wroclaw Medical University

National Institute of Public Health

Polish Academy of Sciences

University of Wrocław

University of Warsaw

Institute for Transfusion Medicine

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Urban Furniture Workshop Group 3: Cyber-Physical Bio Dune

Zenodo (CERN European Organization for Nuclear Research) (2021)

Henriette Bier Max Latour Adrianna Karnaszewska Agnieszka Trzcińska Karolina Krzyżanowska

Presented design acts as a response to the urban needs of its inhabitants, be it humans, animals or any natural
habitats. The aspect of retaining the biodiversity in modern cities emerges to the forefront, the response takes
inspiration from the natural environment and possibilities that the most innovative technology offers. It was established
as a part of the AR0122 1:1 Interactive Architecture Prototypes Workshop at TU Delft and included the
use of Design-to-Robotics Production and Operation (D2RP&O) techniques.
The design is based on a shape of a dune that later on is translated into a 3D printed structure, the use of 3D printing
technology allowed to produce a form that corresponds to the functional division, propose a solution efficient
both in the use of materials and the process, as well as integrate data and information within the built structure.
The use of sensor-actuators brings the possibility to interact with the users and collect data useful for determining
future decisions of the bench placement, its main functions, as well as informing any parties interested in data
harvesting.

10.5281/zenodo.4725332

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Strains of Enterobacter cloacae Isolated in a Hospital Environment – Some Phenotypic and Genotypic Properties

Indoor and Built Environment (2006)

Katarzyna Pancer Gut W Szymon Fila Agnieszka Trzcińska Anna Roszkowiak

The aim of this study was to characterise the 34 Enterobacter cloacae strains isolated from different places in a hospital, either from patients who were infected or colonised and from the body surface of German cockroaches ( Blatella germanica) caught in hospitals. A number of factors were determined: the ability of E. cloacae strains to adhere to the HEp-2 cell line, their susceptibility to drugs, the activity of disinfectant agents to planktonic cells and effectiveness of those disinfectants to bacteria that are sessile on catheters as well as the Enterobacterial Repetitive Intergenic Consensus – Polymerase Chain Reaction (ERIC-PCR) profile of the strains. On the basis of a statistical analysis of all the phenotypic results we were able to distinguish a few clusters. The majority of them consisted of strains isolated from colonisation and infection of patients. Some clusters consisted of E. cloacae from all the test sites. Some strains showed similarities of their phenotypic properties as well as the ERIC-PCR profile. Epidemiological studies are continuing.

Enterobacter cloacae

Colonisation

Intergenic region

10.1177/1420326x06062372

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[Evaluating of influence of repeated thaw/freeze cycles on IgG and IgM stability].

Medycyna Doświadczalna i Mikrobiologia (2010)

Joanna Siennicka Anna Laskowska Agnieszka Trzcińska

The purpose of this study was evaluating influence of repeated cycles of thawing and freezing serum samples on IgG and IgM stability. Serum positive samples for anti-cytomegalovirus and antimeasles virus IgG and/or IgM were aliquoted. Tubes containing 100 microl aliquot were frozen at -20 degrees C. Samples were repetitively thawed and froze in one to ten cycles. Antibodies presence was examined with commercially available ELISA tests. All samples reminded positive even after ten repeated thaw/freeze cycles.

Cytomegalovirus

Immunoglobulin M

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Wpływ wybranych czynników przedanalitycznych na wyniki oznaczeń wirusowego DNA metodą PCR

Medycyna Doświadczalna i Mikrobiologia (2012)

Agnieszka Trzcińska Anna Laskowska Irena Brodzka Joanna Siennicka

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Częstość występowania aktywnych zakażeń wirusami z rodziny Herpesviridae wśród członków rodzin wychowujących dzieci

Medycyna Doświadczalna i Mikrobiologia (2014)

M Dudal-Szczepaniak Agnieszka Trzcińska A Czescik J Siennicka

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[The prevalence of active infection with viruses from the family Herpesviridae among members of families with children].

PubMed (2014)

Milena Dunal-Szczepaniak Agnieszka Trzcińska Agnieszka Częścik Joanna Siennicka

Cytomegalovirus infection (CMV) is one of the most common viral infections during pregnancy and one of the most common causes of birth defects in newborns. CMV infection occurs mostly through close contact with small children who can secrete the virus in saliva and urine. Children, especially in preschool and early school can also be a source of infection with other herpesviruses. The aim of the study was to determine the prevalence of active infections caused by viruses from the family Herpesviridae (CMV, EBV, VZV) among members of families with children.The study included 24 families raising children aged from 2 to 18 years. From all members of the families (46 adults and 39 children) saliva samples were collected from which DNA was extracted. The isolated DNA samples were tested for the presence of CMV, EBV, VZV genetic material by nested PCR. In addition, each family carried out a survey.The presence of CMV DNA in saliva samples were detected in members of 7 families and the presence of EBV DNA were detected in members of 11 families. Total DNA of CMV was detected in 8/85 samples of saliva (9.41%), of which 1/46 adults (2.17%) and 7/39 children (17.95%) and EBV DNA was detected in 18/85 tested saliva samples (21,18%) - 13/46 samples from adults (28,26%) and 5/39 samples from children (12,82%). VZV DNA was not detected in any of the tested saliva samples. The obtained results indicate that the active, asymptomatic infections with lymphotropic herpesviruses are common and affect more than 10% (CMV) and 20% (EBV) subjects.

Cytomegalovirus

Betaherpesvirinae

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[Temperature sensitive mutant of Herpes simplex virus type 1. II. Neurovirulence and latency].

PubMed (2001)

B Litwińska Agnieszka Trzcińska M Kańtoch

The course of acute infection of mice with ts mutant or the native strain DNA and the antigens of HSV in brain nerve cells were determined. Virus DNA was detected in brains of all mice in both animal groups while the virus antigens--only in cells of mice infected with the native strain. It can be suggested, therefore, that the ability of ts mutant to replicate in central nervous system of the infected mice is lacking or much lower. The detection of virus nucleic acid 3-5 months after virus infection might indicate a possibility of establishing latent infection. However, ts mutant showed a significantly lower possibility of latency induction, as compared with highly virulent strains. It was found that the mutant ability to induce latent infection was markedly increased when mice were treated with both ts mutant and Depo-Medrol as immunosuppressive agent. This finding shows both a possibility of increase of frequency of latent infections in the state of immunosuppression, and of activation of the latent infection (recurrence of acute form of infection).

Latent Virus

Immunosuppression

Virus latency

Reversion

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Antiviral Disinfection In The Medical Area

Postępy Mikrobiologii - Advancements of Microbiology (2019)

Agnieszka Trzcińska

Abstract Hospital-acquired infections (HAIs) are a serious public health problem. This problem affects hundreds of millions of people every year, leading to many serious health complications. Disinfection is an important element in the prevention and control of viral infections, which is the basis of sanitation and hygiene processes in medical facilities such as hospitals, outpatient clinics, dental offices, etc. The disinfection is a complex process, the efficacy of which is influenced by many factors. The disinfectant, apart from the fact that it requires competent and proper use, also has to meet certain criteria, including the wide range of biocidal activity confirmed by well-known and well-designed research methods. 1. Introduction. 2. Disinfection. 3. The effectiveness of the disinfection process. 4. Requirements for disinfectants. 5. Testing of virucidal activity of disinfectants. 6. Antiviral disinfection – practical aspects

Disinfectant

Water disinfection

10.21307/pm-2019.58.1.101

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[Temperature sensitive mutant of Herpes simplex virus type 1. I. Pathogenicity and immunogenicity].

PubMed (2001)

B Litwińska Agnieszka Trzcińska M Kańtoch

The aim of the study was to characterize biological features of the sensitive mutant of HSV-1, derived from McIntyre strain by numerous virus passages at lowered replication temperature (28 degrees C). Pathogenicity of obtained ts mutant for inbred mice lines, CFW/Pzh and BALB/cPzh, was determined. Statistically significant decrease in virulence of the mutant for these mouse lines was demonstrated, as compared with the native virus strain, propagated at 37 degrees C. Immunogenic activity of ts mutant of HSV-1 defined by the possibility of mouse protection against infection with high virulent was determined. Mice, which at the time of immunization with ts mutant received Depo-Medrol--an immunosuppressive agent--were also found to be capable of inducing defense mechanisms to infection with the native strain.

Strain (injury)

Attenuated vaccine

Inbred strain

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[Raji, P3HR-1 and Namalwa cells as a model for the study of Epstein-Barr virus (EBV) reactivation].

Medycyna Doświadczalna i Mikrobiologia (2010)

Olga Rek Agnieszka Częścik Agnieszka Trzcińska Joanna Siennicka

The aim of the study was to characterize Raji, P3HR-1 and Namalwa cell lines in the aspect of their usefulness for the research on virus Epstein-Barr (EBV) reactivation, with the participation of Toll-like receptors (TLR). During a 12-day experiment, optimal conditions of cultivation (RPMI with 10% FCS at 37 degrees C in 5% CO2) were determined. In these conditions cells showed logarithmic growth. The presence of the DNA EBV was confirmed by the PCR method, showing that 12-day long maintenance of cells does not cause the loss of the virus. The presence of genes encoding TLR2, TLR3 and TLR4 was also confirmed by PCR. The TLRs expression at the mRNA level in cells subjected to 24h stimulation with TLR2, TLR3 and TLR4 agonist (Pam3CSK4, Poly(I:C) and LPS, respectively) was determined by the RT PCR method. The presence ofTLR4 mRNA was confirmed in the case of Namalwa cells stimulated by Pam3CSK and LPS, and P3HR cells stimulated by Pam3CSK4. In the case of Raji cells the expression of none of the receptors was confirmed at the mRNA level in cells with and without stimulation.

Raji cell

TLR3

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