Background and Design: Bullous pemphigoid is a rare autoimmune blistering disease.The aim of this study was to investigate the epidemiological characteristics and clinical, laboratory, and radiological features of patients with bullous pemphigoid in Erzurum and to evaluate the association of bullous pemphigoid with comorbid diseases.Methods and Methods: Medical records of 38 patients, who were diagnosed with bullous pemphigoid after biopsy and hospitalized in our clinic between 2003 and 2013, were retrospectively studied.Results: Fifteen (39.5%) of the 38 patients were male, and 23 (60.5%) were female.The mean age at the time of diagnosis was 62.4±21 years.Analyses of the results of direct immunofluorescence showed that the most common finding was the presence of IgG and C3 (42.1%).The average time since the first presentation until diagnosis was 72.7±104.3days.The mean initial dose of corticosteroid was 54.7±26.01mg/ day.The mean length of hospitalization for bullous pemphigoid was 22.6±23.5 days.We did not detect any malignancy or comorbid diseases associated with bullous pemphigoid.However, eosinophilia was detected.Conclusions: Routine laboratory and radiological investigations are not necessary to detect malignancy in patients with bullous pemphigoid.(Turkderm 2015; 49: 66-9)
Nitrojen kriyobiyoloji, kriyoterapi ve tarimda kullanilan kimyasal bir maddedir. Burada, cilek yapraklarina kullanilan nitrojen bazli gubreye maruz kalinmasi sonrasi her iki bacaginda ciddi bulloz lezyonlari gelisen, 19 yasinda erkek ciftci olgusunu sunduk. Literaturde gubrenin tetikledigi kontakt dermatitler cok nadirdir. Bu olguda mesleki gubreye temasin onlenmesinin onemini vurgulamak istedik.
Schnitzler syndrome is an autoimmune disease characterized with chronic urticarial rashes, monoclonal gammopathy, intermittent fever, arthralgia, arthritis, bone pain, lymphadenopathy, hepatosplenomegaly, leukocytosis and elevated erythrocyte sedimentation rate (ESR). Schnitzler syndrome must be investigated in urticaria which is long acting and unresponsive to classic treatments. Lymphoproliferative disorders may accompany to Schnitzler syndrome. Although there are many kinds of treatments, response to anakinra is well. Our case was 74 years old man presented with urticarial papule and plaques on his upper part of body and proximal part of extremities. Fever, arthralgia and neutropenia were together with his lesions. Patient was used systemic steroid and antihistaminic with diagnosis of urtica. Schnitzler syndrome was diagnosed. We decided to represent this case because Schnitzler syndrome accompanied to multiple myeloma is very rare in literature and diagnosis is often delayed. Key words: Multiple Myeloma; Schnitzler Syndrome.
Lenfanjioma sirkumskriptum (LS) lenfatik kanalların hamartomatöz vasküler bir malformasyonudur.Etyolojisi tam olarak anlaşılmamıştır.Genellikle konjenitaldir.Lezyonlar ince duvarlı ve grup yapmış veziküller ile karakterizedir.Lezyonlar genellikle ekstremite proksimalleri, omuz, aksilla, karın ve boyun bölgesinde görülür.Nadir olarak genital ve oral mukozada görülebilir.Olgumuz 20 yaşında
Lichen sclerosus is a chronic sclerosing inflammatory disease. The disease is 6-10 times more common in women and more frequent between the ages of 8-13 and 50-60 years. Etiology is unknown exactly. But autoimmunity, genetic, hormonal factors, infections and trauma may be responsible in etiology. A patient, a 53-year-old woman, admitted to our clinic with white papules on her wrists and feet dorsum. Emollients, high potency topical steroids, topical tacrolimus, antimalarial drugs, systemic or intralesional steroids, narrow band UVB, PUVA, carbon dioxide laser and surgery may be used in treatment. Cases of lichen sclerosus mimicking lichen planus are rarely seen in the literature and these situations may be confused with each other. We report this case for the unusual presentation of lichen sclerosus and hiperkeratotic form.
Pityriasis Iichenoides is a rare cutaneous disorder of clearly unknown etiology and speculated to be an infl ammatory response triggered by many infectious agents. We report a case of pityriasis lichenoides et varioliformis acuta (PLEVA) in a 7 year old boy. Lesions occurred abruptly aft er administration of combined diphtheria, tetanus, acellular pertussis and inactivated polio vaccine (DTaP/IPV). We want to emphasize that our case is the fi rst case report associated with this vaccine in literature and it is successfully treated with clarithromycin.
Liken sklerozus kronik inflamatuvar sklerozan bir hastaliktir. Kadinlarda 6-10 kat daha fazla ve 8-13 yas arasi ve 50-60 yas arasi daha sik gorulmektedir. Etyopatogenezi tam olarak bilinmemektedir. Fakat otoimmunite, genetik, hormonal faktorler, enfeksiyon ve travma uzerinde durulmaktadir. El ve ayaklarinda cok sayida deriden kabarik dokuntuler ile poliklinigimize muracaat eden 53 yasindaki kadin hastanin kliniginde beyaz renkte papulleri vardi. Tedavide emolyenler, yuksek potent topikal steroidler, topikal takrolimus, antimalaryal ilaclar, sistemik ya da intralezyonal steroid, darbant UVB, PUVA, karbondioksit lazer ve cerrahi uygulanabilir. Literaturde liken planusu taklit eden liken sklerozus vakalari nadir oldugu icin ve her iki durumun birbiriyle karisabilecegine dikkat cekmek amaciyla bu olguyu sunmayi uygun gorduk.
Ozet Abstract Romberg Parry sendromu nadir gorulen ve idiopatik norokutanoz bir bozukluktur. Subkutan doku, kas ve kraniofasyal kemiklerde progresif fasyal hemiatrofi gorulebilir. Etiyolojisinde travma, heredite, sempatik sinir sistemi hipo-hiperaktivitesi, enfeksiyonlar, otoimmunite, trigeminal sinir anomalileri ve norovaskuler bozukluklari vardir. Tedavide rekonstruktif cerrahi teknikleri, lipo enjeksiyon, silikon implantasyonu, metotrexate, steroid, UVA-1 ve PUVA kullanilabilir. Olgumuz 2 yildir govdede ve ekstremitelerde cok sayida beyaz renkte plaklari, zigomatik ve temporomandibular alanda hemifasyal atrofisi olan 6 yasinda kiz cocuguydu. Laboratuvar ve radyolojik tetkiklerinde ozellik yoktu. Romberg Parry sendromu tanisi konuldu. Literaturdeki Romberg Parry sendromu olgulari genellikle lineer skleroderma ile iliskilidir. Romberg Parry sendromu nadir goruldugu ve olgumuz generalize morfea ile iliskili oldugu icin bu olguyu sunmaya karar verdik. Romberg Parry syndrome is an idiopathic neurocutaneous disorder which is rarely seen. Progressive facial hemiatrophy may be seen in subcutaneous tissue, muscle and craniofacial bones. There are trauma, heredity, hypohyperactivation of Sympathetic nervous system, infections, autoimmunity, anomalies of trigeminal nerve and neurovascular disorders. Reconstructive surgery technical, lipo injection, silicon implantation, methotrexate, steroid, UVA1 and PUVA can be used in treatment. Our case was 6 years old girl presented with multiple white plaques on her body and extremities and hemifacial atrophies on her zygomatic and temporomandibular area. Laboratory and radiologic investigations were unremarkable. Diagnosis was Romberg Parry syndrome. Cases of Romberg Parry syndrome are generally associated with linear scleroderma in literature. We decided to report this case because Romberg Parry syndrome is very rare and our case was associated with generalized morphea.
Erlotinib bir epidermal buyume faktoru reseptoru inhibitorudur. Direncli, lokal yayilmis ya da metastaz yapmis kucuk hucreli disi akciger kanserlerinde kullanilir. Erlotinib sitotoksik ilaclar gibi ciddi sistemik yan etkiler olusturmaz. Fakat ciltte toksik yan etkiler yapabilir. Erlotinib kullanimina bagli en sik gelisen cilt lezyonu akneiform erupsiyondur. Etyolojide keratinositler, ekrin ve sebase bez hucreleri ve sac folikul hucrelerindeki farklilasma ve olgunlasmasindaki dengenin bozuldugu dusunulmektedir. Tedavide topikal metronidazol, topikal klindamisin, topikal salisilik asit ve tetrasiklin kullanilabilir. Cok agir akneiform erupsiyonlarda erlotinibin dozu azaltilabilir ya da tedavi ertelenebilir. Olgumuz kucuk hucreli disi akciger kanseri icin erlotinib tedavisi sonrasinda yuzunde akneiform erupsiyon gelisen 67 yasinda erkek hastaydi. Hastaya lokal klindamisin fosfat ve benzoil peroksit karisimi tedavisi verildi. Erlotinib tedavisine bagli gelisen cilt lezyonlarinin erken taninmasi ve tedavi edilmesi hastanin erlotinib tedavisi uyumu acisindan onemli oldugu icin bu olguyu sunmaya karar verdik. Anahtar sozcukler: Akneiform erupsiyon, erlotinib, kucuk hucreli disi akciger kanseri
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