Xi Chen

Nanjing University

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Chen‐Yu Zhang

Nanjing University

Wenyuan Xu

East China Jiaotong University

Ke Zen

Nanjing Drum Tower Hospital

Yongxin Liu

East China Jiaotong University

Hongwei Liang

China Three Gorges University

Jiali Zhang

East China Jiaotong University

Zhen Zhou

PowerChina (China)

Shaoming Yang

East China Jiaotong University

Zhili Fang

East China Jiaotong University

Yanbo Wang

Nanjing University

Cooperative Institutions

Nanjing University

244

Chinese Academy of Sciences

172

Nanjing Medical University

160

Chinese Academy of Medical Sciences & Peking Union Medical College

160

Nanjing Drum Tower Hospital

143

Shanghai Jiao Tong University

133

Sun Yat-sen University

114

Peking University

100

Sichuan University

Central South University

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STUDY ON ACQUIRED HOSPITAL INFECTION RELATED FACTORS IN ELDERLY PATIENTS IN THE DEPARTMENT OF RESPIRATORY MEDICINE AND THE CLINICAL PREVENTIVE MEASURES

Xiandai yufang yixue (2007)

Xi Chen

[Objective]To explore the risk factors of acquired hospital infection in elderly patients in the department of respiratory medicine,and the infection routes as well as the pathogens and the drug resistance.[Methods]A retrospective study was performed on 982 elderly patients in the department of respiratory medicine in our hospital from January,2000 to December,2005.[Results]The risk factors of acquired hospital infection in elderly patients in department of respiratory medicine were long-time hospitalization,use of mechanical ventilation,pulmonary diseases and the administration of broad-spectrum antibiotic. Sputum and bolld were cultured for the pathogens,among which Gram-positive bacteria accounted for 85% and Gram-negative bacteria accounted for 14.2%.[Conclusion]The preventive measures of hospital infection include eliminating infection sources,cutting off infection routes and protecting susceptible people in order to achieve the purpose of effectively controlling hospital infection in elderly patients in the department of respiratory medicine.

Respiratory Medicine

Respiratory infection

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Acute biliary peritonitis following T tube extraction

Xi Chen

Objective To investigate the causes,prevention and treatment of acute biliary peritonitis following T tube extraction Methods Seventeen patients with acute biliary peritonitis following T tube extraction were reviewed and analyzed The causes,prevention,treatment and diagnosis of the serious complication and the time of T tube extraction were discussed Results In the 17 patients,6 recovered with the conservative treatment and 11 were cured by the re-operation Of 11 patients with re-laparotomy,there were 6 with poor formation of the sinus,2 with tears of the sinus, 1 with the over-length of the sinus and 2 with improper T tube extraction Conclusion The prevention of acute biliary peritonitis following T tube extraction should be emphasized Once it happens the vigorous measures to treat this critical complication should be adopted individually

Sinus (botany)

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Mechanistic investigations of the disproportionation reaction catalyzed by AlCl3/NH2-MIL-53(Al) to produce dimethyldichlorosilane

Silicon (2023)

Wenyuan Xu Zhaohua Cheng Liubin Mo Haoting Si Mengsha Shen

Organosilicon

10.1007/s12633-023-02784-x

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BAP1 suppresses lung cancer progression and is inhibited by miR-31

Oncotarget (2016)

Mengchao Yu Hongwei Liang Zheng Fu Xueliang Wang Zhicong Liao

BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme that serves as a tumor suppressor in lung cancer; however, its function and its regulation are largely unknown. In this study, we found that BAP1 protein levels were dramatically diminished in lung cancer tissues while its mRNA levels did not differ significantly, suggesting that a post-transcriptional mechanism was involved in BAP1 regulation. Because microRNAs (miRNAs) are powerful post-transcriptional regulators of gene expression, we used bioinformatic analyses to search for miRNAs that could potentially bind BAP1. We predicted and experimentally validated miR-31 as a direct regulator of BAP1. Moreover, we showed that miR-31 promoted proliferation and suppressed apoptosis in lung cancer cells and accelerated the development of tumor growth in xenograft mice by inhibiting BAP1. Taken together, this study highlights an important role for miR-31 in the suppression of BAP1 in lung cancer cells and may provide insights into the molecular mechanisms of lung carcinogenesis.

Zhàng

10.18632/oncotarget.7328

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Citations (35)

Mechanism of Gas-Phase Sulfur Modified Fe-Ce Catalysts in the Nh3-Scr Reaction

Zhongxian Song Dujuan Mo Xueji Zhang Yanli Mao Xueping Liu

Selective catalytic reduction

10.2139/ssrn.4930709

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Surface Reaction Mechanism of ZSM-5(3T)@NH2-MIL-53(Al) Core-Shell Catalyst for Dimethyldichlorosilane Synthesis

Journal of Solid State Chemistry (2024)

Wenyuan Xu Kehan Wu Y. Wang Linhong Bao Yu Xu

ZSM-5

10.1016/j.jssc.2024.125127

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Engineering of l-threonine aldolase for the preparation of 4-(methylsulfonyl)phenylserine, an important intermediate for the synthesis of florfenicol and thiamphenicol

Enzyme and Microbial Technology (2020)

Zhicheng Liu Xi Chen Qijia Chen Jinhui Feng Min Wang

Aldol reaction

Enantiopure drug

10.1016/j.enzmictec.2020.109551

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Cholecystokinin-Expressing Interneurons in Basolateral Amygdala Mediate Stress-induced Anxiety-like Behaviors in Mice

Neurobiology of Stress (2024)

Wei Fang Xi Chen Jufang He

Basolateral amygdala

10.1016/j.ynstr.2024.100680

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Effects of surface treatments on the bonding properties of polyetherketoneketone to dentin: An in vitro study

Journal of Prosthetic Dentistry (2021)

Chenwei Wang Fangfang Sun Jiaqi Zhang Xi Chen Guofeng Wu

Abrasion (mechanical)

Dental bonding

Particle (ecology)

10.1016/j.prosdent.2021.08.012

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Citations (4)

Baicalin, the major component of traditional Chinese medicine Scutellaria baicalensis induces colon cancer cell apoptosis through inhibition of oncomiRNAs

Scientific Reports (2018)

Yili Tao Shoubin Zhan Yanbo Wang Geyu Zhou Hongwei Liang

Colorectal cancer (CRC) is among the most frequently occurring cancers worldwide. Baicalin is isolated from the roots of Scutellaria baicalensis and is its dominant flavonoid. Anticancer activity of baicalin has been evaluated in different types of cancers, especially in CRC. However, the molecular mechanisms underlying the contribution of baicalin to the treatment of CRC are still unknown. Here, we confirmed that baicalin can effectively induce and enhance apoptosis in HT-29 cells in a dose-dependent manner and suppress tumour growth in xenografted nude mice. We further performed a miRNA microarray analysis of baicalin-treated and untreated HT-29 cells. The results showed that a large number of oncomiRs, including miR-10a, miR-23a, miR-30c, miR-31, miR-151a and miR-205, were significantly suppressed in baicalin-treated HT-29 cells. Furthermore, our in vitro and in vivo studies showed that baicalin suppressed oncomiRs by reducing the expression of c-Myc. Taken together, our study shows a novel mechanism for anti-cancer action of baicalin, that it induces apoptosis in colon cancer cells and suppresses tumour growth by reducing the expression of c-Myc and oncomiRs.

Baicalin

Scutellaria

Baicalein

10.1038/s41598-018-32734-2

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Citations (104)