Noah A. Cohen

Icahn School of Medicine at Mount Sinai

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Ronald P. DeMatteo

Memorial Sloan Kettering Cancer Center

Adrian M. Seifert

TU Dresden

Megan H. Crawley

Memorial Sloan Kettering Cancer Center

Teresa S. Kim

University of Washington

Shan Zeng

Xiangya Hospital Central South University

Ferdinand Rossi

Hospital of the University of Pennsylvania

Cristina R. Antonescu

Memorial Sloan Kettering Cancer Center

Peter Besmer

Memorial Sloan Kettering Cancer Center

Michael J. Cavnar

University of Kentucky

Umut Sarpel

Harvard University

Cooperative Institutions

Memorial Sloan Kettering Cancer Center

128

Icahn School of Medicine at Mount Sinai

Kettering University

Gynecologic Oncology Group

Cornell University

Spanish Oncology Genitourinary Group

Mount Sinai Hospital

NYU Langone Health

Stellar Science (United States)

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Angiogenesis inhibition augments the effect of imatinib in gastrointestinal stromal tumor

Journal of the American College of Surgeons (2013)

Noah A. Cohen Shan Zeng Teresa S. Kim Michael J. Cavnar Adrian M. Seifert

Stromal tumor

10.1016/j.jamcollsurg.2013.07.327

Cite

Citations (2)

Preoperative frailty and malnutrition is associated with worse postoperative outcomes

HPB (2023)

Nazanin Khajoueinejad S. Imtiaz Alison Buseck Yael Berger Eric Pletcher

Modalities

10.1016/j.hpb.2023.05.126

Cite

Citations (0)

Table S2 from Wnt/β-catenin Signaling Contributes to Tumor Malignancy and Is Targetable in Gastrointestinal Stromal Tumor

Shan Zeng Adrian M. Seifert Jennifer Q. Zhang Michael J. Cavnar Teresa S. Kim

<p>Supplementary Table 2: Primary untreated (Prim/UT) KIT+ ( n = 8 ) vs. Metastatic resistant (Met/Res) KIT+ ( n = 4). Significant genes with a False Discovery Rate of < 0.05 and a fold change > 2.0</p>

Table (database)

Stromal tumor

10.1158/1535-7163.22508971.v1

Cite

Citations (0)

Preoperative Frailty and Malnutrition in Surgical Oncology Patients Predicts Higher Postoperative Adverse Events and Worse Survival: Results of a Blinded, Prospective Trial

Annals of Surgical Oncology (2023)

Nazanin Khajoueinejad Elad Sarfaty Allen T. Yu Alison Buseck Samantha Troob

Surgical oncology

10.1245/s10434-023-14693-9

Cite

Citations (4)

Prophylactic Cholecystectomy is Safe in Patients Undergoing Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy

The American Surgeon (2024)

David N. Hanna Nazanin Khajoueinejad Muhammad Owais Abdul Ghani Andrew Hermina Alexander Mina

Background While cholecystectomy is one of the most common operations performed in the United States, there is a continued debate regarding its prophylactic role in elective surgery. Particularly among patients with peritoneal carcinomatosis who undergo cytoreduction surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), further abdominal operations may pose increasing morbidity due to intraabdominal adhesions and potential recurrence. This bi-institutional retrospective study aims to assess postoperative morbidity associated with prophylactic cholecystectomy at the time of CRS-HIPEC. Methods We performed a bi-institutional retrospective analysis of 578 patients who underwent CRS-HIPEC from 2011 to 2021. Postoperative outcomes among patients who underwent prophylactic cholecystectomy at the time of CRS-HIPEC were compared to patients who did not, particularly rate of bile leak, hospital length of stay, rate of Clavien-Dindo classification morbidity grade III or greater, and number of hospital re-admissions within 30 days. Results Of the 535 patients available for analysis, 206 patients (38.3%) underwent a prophylactic cholecystectomy. Of the 3 bile leaks (1.5%) that occurred among patients who underwent prophylactic cholecystectomy, all 3 occurred in patients who underwent a concomitant liver resection. There were no significant differences in hospital length of stay, postoperative morbidity, and number of hospital re-admissions among patients who underwent prophylactic cholecystectomy compared to those who did not. Conclusion Prophylactic cholecystectomy in patients undergoing CRS-HIPEC is not associated with increased morbidity or increased bile leak risk compared to historical data. While the benefits of prophylactic cholecystectomy are not yet elucidated, it may be considered to avoid potential future morbid operations for biliary disease.

Hyperthermic Intraperitoneal Chemotherapy

Bile leak

Concomitant

10.1177/00031348241246171

Cite

Citations (1)

ISRAEL’S DEMENTIA PLAN: PRIMARY CARE INTERVENTIONS IMPROVING CARE OF OLDER PEOPLE WITH DEMENTIA

Innovation in Aging (2018)

John Lemberger Shelley A. Sternberg S Alon Iris Rasooly Aaron Cohen

Israel launched its National Plan to Address Alzheimer’s Disease and Other Dementias in 2013. The objective of the first project was to encourage programs in the primary care setting of Israel’s four health funds to raise awareness of the disease, train health professional and implement pilot projects. Each fund implemented a program specific to its organization, eg targeting elderly diabetes patients, proactive cognitive and geriatric assessment for members aged 75, developing a dementia registry and initiating other interventions. The evaluative study is presented. Interviews of medical management, and health professionals, including physicians, nurses, and social workers; administering structured questionnaires at training programs held to instruct and train health professionals on dementia assessment and treatment. In each fund dementia assessment and care received heightened focus. eg, new training programs for health professionals, increased screening and diagnosis,, increased referral of members of the health funds and their families to dementia-specific social services, NGOs, and community resources. Training lead to improved awareness among health professionals of the importance of (timely) diagnosis. Health funds developed the data available on persons with dementia or those at risk, by developing dementia registries, including comorbidities, drugs and other important markers to assist the primary care physicians and teams. The evaluation demonstrated that many of the program’s objectives were achieved. Decisions on policy and furthering the care of persons with dementia in the health care system will be advanced by the results of this evaluation in furthering policy decisions.

10.1093/geroni/igy031.3428

Cite

Citations (0)

A total neoadjuvant chemotherapy approach is associated with improved recurrence‐free survival in patients with colorectal peritoneal metastases undergoing cytoreductive surgery and HIPEC

Journal of Surgical Oncology (2022)

David N. Hanna Rebekah Macfie Muhammad Owais Abdul Ghani Andrew Hermina Alexander Mina

Abstract Background The primary aim of this study is to evaluate the oncologic outcomes of two popular systemic chemotherapy approaches in patients with colorectal peritoneal metastases (CPM) undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC). Methods We performed a dual‐center retrospective review of consecutive patients who underwent CRS‐HIPEC for CPM due to high or intermediate‐grade colorectal cancer. Patients in the total neoadjuvant therapy (TNT) group received 6 months of preoperative chemotherapy. Patients in the “sandwich” (SAND) chemotherapy group received 3 months of preoperative chemotherapy with a maximum of 3 months of postoperative chemotherapy. Results A total of 34 (43%) patients were included in the TNT group and 45 (57%) patients in the SAND group. The median overall survival (OS) in the TNT and SAND groups were 77 and 61 months, respectively ( p = 0.8). Patients in the TNT group had significantly longer recurrence‐free survival (RFS) than the SAND group (29 vs. 12 months, p = 0.02). In a multivariable analysis, the TNT approach was independently associated with improved RFS. Conclusion In this retrospective study, a TNT approach was associated with improved RFS, but not OS when compared with a SAND approach. Further prospective studies are needed to examine these systemic chemotherapeutic approaches in patients with CPM undergoing CRS‐HIPEC.

Hyperthermic Intraperitoneal Chemotherapy

10.1002/jso.27136

Cite

Citations (5)

Distal Cholangiocarcinoma – Should we Shift the Treatment Paradigm?

HPB (2022)

Yael Berger Rebekah Macfie H. Liu Thomas M Li S. Imtiaz

Paradigm shift

10.1016/j.hpb.2022.05.1003

Cite

Citations (0)

Hyperthermic intraperitoneal chemotherapy does not increase risk of major complication or failure to rescue in cytoreductive surgery

Journal of Surgical Oncology (2022)

Rebekah Macfie Da Eun Elizabeth M. Gleeson Allen T. Yu Noah A. Cohen

Failure to rescue (FTR) is defined as death after a major complication. We evaluated FTR after cytoreductive surgery (CRS) with and without hyperthermic intraperitoneal chemotherapy (HIPEC).The ACS NSQIP database 2005-2018 was reviewed for all cases of CRS. Propensity score matching was used to compare outcomes between those undergoing CRS alone and those undergoing CRS/HIPEC. Patients were matched on age, sex, ascites, diabetes, hypertension and resection of liver, pancreas, colon/rectum, diaphragm, stomach, small bowel, and/or spleen.Thirty nine thousand one hundred and twenty-six patients underwent CRS; 38,387 underwent CRS alone; 739 underwent CRS/HIPEC. After matching there were 726 patients in each arm. Patients undergoing CRS/HIPEC had higher risk of reintubation (25 [3.4%] vs. 13 [1.8%] p = 0.049), urinary tract infection UTI (44 [6.1%] vs. 25 [3.4%] p = 0.019) and sepsis (73 [10.1%] vs. 44 [6.1%] p = 0.005). Patients in the CRS arm required more transfusions (229 [31.5%] vs. 176 [24.2%] p = 0.002). There was no significant difference in FTR between the CRS and CRS/HIPEC groups (11 [4.0%] vs. 6 [2.3%] p = 0.258), nor in the pooled incidence of major complications (275 [37.9%] vs. 262 [36.1%] p = 0.48).CRS/HIPEC is associated with increased rates of reintubation, UTI, and sepsis while CRS alone was associated with increased transfusion. However, the addition HIPEC to CRS did not increase the risk of pooled major complication or FTR.

Hyperthermic Intraperitoneal Chemotherapy

Ileus

10.1002/jso.26969

Cite

Citations (2)

Colony Stimulating Factor Receptor 1 (CSF1R) Inhibition Impairs Liver Regeneration

Journal of the American College of Surgeons (2014)

Juan A. Santamaria‐Barria Jonathan B. Greer Shan Zeng Adrian M. Seifert Noah A. Cohen

10.1016/j.jamcollsurg.2014.07.046

Cite

Citations (0)