17.0%±4.1,p=0.01.There was no significant GLS or RLS improvement in C Group patients. GLS in STEMI patientsConclusions: After STEMI and ventricular dysfunction, only patients treated with G-CSF showed a significant improvement of EF at 6 months.Moreover, only in these patients, 2D GLS improved at 6 months.This effect was observed in remote areas, too, maybe showing long lasting and diffuse effects of the cytokine.
Abstract Changes in platelet physiology are associated with simultaneous changes in microRNA concentrations, suggesting a role for microRNA in platelet regulation. Here we investigated potential associations between microRNA and platelet reactivity (PR), a marker of platelet function, in two cohorts following a non-ST elevation acute coronary syndrome (NSTE-ACS) event. First, non-targeted microRNA concentrations and PR were compared in a case (N = 77) control (N = 76) cohort within the larger TRILOGY-ACS trial. MicroRNA significant in this analysis plus CVD-associated microRNAs from the literature were then quantified by targeted rt-PCR in the complete TRILOGY-ACS cohort (N = 878) and compared with matched PR samples. Finally, microRNA significant in the non-targeted & targeted analyses were verified in an independent post NSTE-ACS cohort (N = 96). From the non-targeted analysis, 14 microRNAs were associated with PR (Fold Change: 0.91–1.27, p-value: 0.004–0.05). From the targeted analysis, five microRNAs were associated with PR (Beta: −0.09–0.22, p-value: 0.004–0.05). Of the 19 significant microRNAs, three, miR-15b-5p, miR-93 and miR-126, were consistently associated with PR in the TRILOGY-ACS and independent Singapore post-ACS cohorts, suggesting the measurement of circulating microRNA concentrations may report on dynamic changes in platelet biology following a cardiovascular ischemic event.
Introduction: Prior studies have demonstrated worse patient outcomes at training institutions during the early months of the academic year, a concept commonly referred to as the “July effect.” Whether the July effect exists in modern interventional cardiology practice is unknown. We hypothesized that percutaneous coronary intervention (PCI) outcomes at training institutions are worse early in the academic year. Methods: All patients undergoing PCI for non-salvage indications from 2009-2011 within the CathPCI Registry ® were eligible for inclusion. To identify training hospitals, we obtained a list of accredited interventional cardiology fellowship programs, matched them to their affiliated hospitals, and linked these training hospitals to the CathPCI Registry database through hospital identification numbers. PCI procedures were categorized as early (July 1-August 31) or non-early (September 1- June 30) based on timing within the academic year. Risk-adjusted in-hospital bleeding and mortality rates were compared for early and non-early time periods using validated risk models. Results: A total of 216,927 procedures were performed in training hospitals during the study period. Early and non-early PCI outcomes were similar (Table 1, early vs. non-early bleeding OR 0.97, CI 0.92-1.02, mortality OR 0.94, CI 0.85-1.03). The associations between PCI timing and in-hospital bleeding and mortality were similar between hospitals with and without training programs (P for interaction 0.59, and 0.95, respectively). Discussion: PCIs performed early in the academic year at training institutions are not associated with worse patient outcomes. Importantly for patients, within these training hospitals, this finding provides reassurance that care is not compromised when it involves trainees early in the academic year.
