Tian Jian Lu

Nanjing University of Aeronautics and Astronautics

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Co-Authors

Feng Xu

Xi'an Jiaotong University

139

Fengxian Xin

Xi'an Jiaotong University

Qiancheng Zhang

Xi'an Jiaotong University

T. Kim

University of the Witwatersrand

Min Lin

Nanjing Medical University

Guy M. Genin

Washington University in St. Louis

Bin Han

Xi'an Jiaotong University

Shaobao Liu

Nanjing University of Aeronautics and Astronautics

Guoyou Huang

Wuhan University

Moxiao Li

Seoul National University

Cooperative Institutions

Xi'an Jiaotong University

341

Chinese Academy of Sciences

110

Nanjing University of Aeronautics and Astronautics

Tsinghua University

Shanghai Jiao Tong University

University of Chinese Academy of Sciences

Sun Yat-sen University

Sichuan University

Zhejiang University

Northwestern Polytechnical University

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Effective mechanical behaviors of transverse isotropic materials embedded compressible liquid inclusions with surface effects

International Journal of Solids and Structures (2024)

Fei Ti Chenlei Yu Moxiao Li Shaobao Liu Tian Jian Lu

10.1016/j.ijsolstr.2024.112903

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Citations (0)

In vitrospatially organizing the differentiation in individual multicellular stem cell aggregates

Critical Reviews in Biotechnology (2014)

Hao Qi Guoyou Huang Yu Han Wang Lin Xiujun Li

With significant potential as a robust source to produce specific somatic cells for regenerative medicine, stem cells have attracted increasing attention from both academia and government. In vivo, stem cell differentiation is a process under complicated regulations to precisely build tissue with unique spatial structures. Since multicellular spheroidal aggregates of stem cells, commonly called as embryoid bodies (EBs), are considered to be capable of recapitulating the events in early stage of embryonic development, a variety of methods have been developed to form EBs in vitro for studying differentiation of embryonic stem cells. The regulation of stem cell differentiation is crucial in directing stem cells to build tissue with the correct spatial architecture for specific functions. However, stem cells within the three-dimensional multicellular aggregates undergo differentiation in a less unpredictable and spatially controlled manner in vitro than in vivo. Recently, various microengineering technologies have been developed to manipulate stem cells in vitro in a spatially controlled manner. Herein, we take the spotlight on these technologies and researches that bring us the new potential for manipulation of stem cells for specific purposes.

Multicellular organism

Embryoid body

Regenerative Medicine

10.3109/07388551.2014.922917

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Citations (26)

A comparative study of continuum damage models for crack propagation under gross yielding

International Journal of Fracture (1992)

C. L. Chow Tian Jian Lu

10.1007/bf00032697

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Citations (15)

Compressive strength and energy absorption of sandwich panels with aluminum foam-filled corrugated cores

Composites Science and Technology (2013)

Leilei Yan Bo Yu Bin Han Chang Chen Q.C. Zhang

Sandwich panel

Aluminium foam sandwich

10.1016/j.compscitech.2013.07.011

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Citations (188)

Fiber Networks: The Plasticity of Nanofibrous Matrix Regulates Fibroblast Activation in Fibrosis (Adv. Healthcare Mater. 8/2021)

Advanced Healthcare Materials (2021)

Yuanbo Jia Yanzhong Wang Lele Niu Hang Zhang Jin Tian

Little attention has been paid to the effect of matrix fiber-network plasticity at the microscale. In article number 2001856, Jin Qian, Guoyou Huang, Feng Xu, and co-workers find a significant decrease in plasticity of native fibrotic tissues, which is associated with increased matrix crosslinking. They demonstrate that the decrease of matrix plasticity promotes fibroblast activation and spreading using a plasticity-controlled 3D culture system, which is mediated through cytoskeletal tension and nuclear translocation of Yes-associated protein.

Microscale chemistry

Matrix (chemical analysis)

10.1002/adhm.202170039

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Engineering three-dimensional cell mechanical microenvironment with

Jinhui Wu Qiancheng Zhang Tian Jian Lu

Cell mechanical microenvironment (CMM) significantly affects cell behaviors such as spreading, migration, proliferation and differentiation. However, most studies on cell response to mechanical stimulation are based on two-dimensional (2D) planar substrates, which cannot mimic native three-dimensional (3D) CMM. Accumulating evidence has shown that there is a significant difference in cell behavior in 2D and 3D microenvironments. Among the materials used for engineering 3D CMM, hydrogels have gained increasing attention due to their tunable properties (e.g. chemical and mechanical properties). In this paper, we provide an overview of recent advances in engineering hydrogel-based 3D CMM. Effects of mechanical cues (e.g. hydrogel stiffness and externally induced stress/strain in hydrogels) on cell behaviors are described. A variety of approaches to load mechanical stimuli in 3D hydrogel-based constructs are also discussed. (Some figures may appear in colour only in the online journal)

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Paracrine Effects of Adipose-Derived Stem Cells on Matrix Stiffness-Induced Cardiac Myofibroblast Differentiation via Angiotensin II Type 1 Receptor and Smad7

Scientific Reports (2016)

Kar Wey Yong Yuhui Li Fusheng Liu Bin Gao Tian Jian Lu

Abstract Human mesenchymal stem cells (hMSCs) hold great promise in cardiac fibrosis therapy, due to their potential ability of inhibiting cardiac myofibroblast differentiation (a hallmark of cardiac fibrosis). However, the mechanism involved in their effects remains elusive. To explore this, it is necessary to develop an in vitro cardiac fibrosis model that incorporates pore size and native tissue-mimicking matrix stiffness, which may regulate cardiac myofibroblast differentiation. In the present study, collagen coated polyacrylamide hydrogel substrates were fabricated, in which the pore size was adjusted without altering the matrix stiffness. Stiffness is shown to regulate cardiac myofibroblast differentiation independently of pore size. Substrate at a stiffness of 30 kPa, which mimics the stiffness of native fibrotic cardiac tissue, was found to induce cardiac myofibroblast differentiation to create in vitro cardiac fibrosis model. Conditioned medium of hMSCs was applied to the model to determine its role and inhibitory mechanism on cardiac myofibroblast differentiation. It was found that hMSCs secrete hepatocyte growth factor (HGF) to inhibit cardiac myofibroblast differentiation via downregulation of angiotensin II type 1 receptor (AT 1 R) and upregulation of Smad7. These findings would aid in establishment of the therapeutic use of hMSCs in cardiac fibrosis therapy in future.

Myofibroblast

Cardiac Fibrosis

10.1038/srep33067

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Citations (53)

Minimum weights of pressurized hollow sandwich cylinders with ultralight cellular cores

International Journal of Solids and Structures (2006)

Tao Liu Zichen Deng Tian Jian Lu

Shearing (physics)

10.1016/j.ijsolstr.2006.09.018

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Citations (42)

End-to-End Optimum ML Detection for DF Cooperative Diversity Networks in the Presence of Interference

IEEE Transactions on Wireless Communications (2015)

Tian Jian Lu Peng Liu Il‐Min Kim François Chan William Read

Unlike the existing detectors, which are developed for decode-and-forward (DF) networks in the ideal interference-free case, we consider a more practical scenario where arbitrary interference exists. We consider a DF cooperative network consisting of a source, multiple relays, a destination, and multiple interferers affecting both the relays and the destination. Each relay is equipped with multiple antennas and knows its local instantaneous channel state information (CSI). Assuming that the destination knows the instantaneous CSI of the source-relay, relay-destination, and source-destination channels, we develop, for the first time in the literature, the end-to-end optimum maximum-likelihood (ML) detectors in closed-form for DF systems employing either simultaneous or orthogonal transmissions in the presence of interference. Furthermore, theoretical analysis shows that the proposed detectors achieve full diversity gains in the presence of interference with finite interference-to-noise ratios. Numerical results demonstrate that the proposed optimum detectors substantially outperform the conventional schemes which simply ignore interference.

Channel state information

Co-channel interference

Cooperative Diversity

Diversity gain

10.1109/twc.2015.2390227

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Citations (4)

Dynamic response and acoustic radiation of double-leaf metallic panel partition under sound excitation

Computational Materials Science (2009)

Fengxian Xin Tian Jian Lu Chang Chen

Baffle

Sound transmission class

Acoustic radiation

10.1016/j.commatsci.2009.04.006

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Citations (25)