Kei‐ichi Sugiyama

National Institute of Health Sciences

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Isao Takeda

Osaka University of Human Sciences

Takashi Kumada

Gifu Kyoritsu University

Masamitsu Honma

National Institute of Health Sciences

Seiki Kiriyama

Ogaki Municipal Hospital

Toshimasa Osada

Pfizer (Japan)

Hidenori Toyoda

Ogaki Municipal Hospital

Satoshi Nakano

Juntendo University

Yoshiko Sugita‐Konishi

Tokyo University of Agriculture

Katsuyoshi Horibata

National Institute of Health Sciences

Atsushi Hakura

Eisai (Japan)

Cooperative Institutions

National Institute of Health Sciences

Kyoto University

Nagoya University

The University of Tokyo

Osaka University

Ogaki Municipal Hospital

Tohoku University

Hokkaido University

Kyushu University

National Institute of Health Sciences

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Usefulness of Measurement of Lens Culinaris Agglutinin-Reactive Fraction of α-Fetoprotein As A Marker of Prognosis and Recurrence of Small Hepatocellular Carcinoma

The American Journal of Gastroenterology (1999)

Kazuhiko Hayashi Takashi Kumada Satoshi Nakano Isao Takeda Kei‐ichi Sugiyama

Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3%) is a recently described marker of hepatocellular carcinoma (HCC), and its usefulness has been demonstrated in many studies. We evaluated the usefulness of serial measurement of AFP-L3% as a marker of prognosis and recurrence after treatment of small HCC.AFP-L3% was measured before and after initial treatment in 60 patients with small HCC (maximum diameter < or = 2 cm). AFP-L3% was taken as the ratio of AFP-L3 to total AFP and multiplied by 100%, and levels > or = 10% were considered positive. Outcomes and recurrence were compared between patients AFP-L3%-negative after initial treatment (Group A, n = 43) and patients who were AFP-L3%-positive after initial treatment (Group B, n = 17).Before treatment, AFP-L3% was positive in 14 (23.3%) of the 60 patients. The cumulative survival rate of Group A was significantly longer (p = 0.0091) than that of Group B. The recurrence rate was significantly higher in Group B (p = 0.0104) than in Group A. When recurrence was limited to intrahepatic metastasis, the recurrence rate was significantly higher in Group B (p = 0.0064). However, the recurrence rate of multicentric occurrence did not differ significantly between Groups A and B.Measurement of AFP-L3% after treatment may be useful for understanding prognosis and recurrence of HCC.

Alpha-fetoprotein

Group A

Group B

10.1111/j.1572-0241.1999.01378.x

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Citations (104)

Study on Heat Transfer Phenomena between the Combustion Flow Field and the Heating Plate during Line Heating Process (3rd Report)

Journal of the Society of Naval Architects of Japan (2001)

Yasumitsu Tomita Naoki Osawa Kiyoshi Hashimoto Nobutaka Shinkai Junji Sawamura

The transient 3-dimensional temperature distribution within the gas flame during line heating is measured in detail by a high performance L. I. F. measurement system. It has been found that the relative distribution of gas temperature around the torch is almost the same as that in spot heating. It has also been found that this relative distribution is almost unchanged regardless of the temperature increase in the steel plate. Thease results lead us to a new hypothesis that the relative distributions of gas temperature and local heat transfer coefficient around the torch remain unchanged and they are almost the same as those in spot heating during line heating process. A new method of heat input estimation for line heating process based on this hypothesis has been propounded.

Torch

Line (geometry)

10.2534/jjasnaoe1968.2001.190_479

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Citations (4)

Treatment of small hepatocellular carcinoma

Cancer Chemotherapy and Pharmacology (1992)

Takashi Kumada Satoshi Nakano Isao Takeda Kei‐ichi Sugiyama Toshimasa Osada

Percutaneous ethanol injection

Liver function

10.1007/bf00687100

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Citations (18)

Aurora-B associated protein phosphatases as negative regulators of kinase activation

Oncogene (2002)

Kei‐ichi Sugiyama Kazumitsu Sugiura Tomohiro Hara Kenji Sugimoto Hiroshi Shima

c-Raf

Aurora inhibitor

MAP2K7

Aurora B kinase

ASK1

Cyclin-dependent kinase 9

10.1038/sj.onc.1205432

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Citations (151)

Mutagenicity of ω-3 fatty acid peroxidation products in the Ames test

Mutation Research/Genetic Toxicology and Environmental Mutagenesis (2017)

Petr Grúz Masatomi Shimizu Kei‐ichi Sugiyama Masamitsu Honma

Ames test

10.1016/j.mrgentox.2017.05.004

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Citations (11)

Long-term monitoring ofParmotrema tinctorumand qualitative changes of air pollution in Shimizu Ward, Shizuoka City, Japan

Journal of Japan Society for Atmospheric Environment / Taiki Kankyo Gakkaishi (2008)

Yoshihito Ohmura Masanobu Kawachi Kazuhiro Ohtara Kei‐ichi Sugiyama

10.11298/taiki1995.43.47

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Citations (5)

Additional file 6: of Negative and positive control ranges in the bacterial reverse mutation test: JEMS/BMS collaborative study

Figshare (2018)

Masayuki Kato Kei‐ichi Sugiyama Toshiro Fukushima Yasuyoshi Miura Takumi Awogi

Figure S5. Dose-response curves of revertant Escherichia coli strain WP2uvrA colonies following treatment with AF-2 in the absence of S9 mix (a), or with 2AA in the presence of S9 mix (b). Individual dose-response curves were generated using results produced by each participating laboratory in 2016 (different colors indicate different laboratories). The doses tested were 0.0025, 0.005, and 0.01 μg/plate for AF-2, and 2.5, 5.0, and 10 μg/plate for 2AA. (ODP 342 kb)

Negative control

Positive control

10.6084/m9.figshare.6084677

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Citations (0)

Impact of diabetes mellitus on the prognosis of patients with hepatocellular carcinoma

Cancer (2001)

Hidenori Toyoda Takashi Kumada Satoshi Nakano Isao Takeda Kei‐ichi Sugiyama

BACKGROUND The majority of patients with hepatocellular carcinoma (HCC) have coexisting cirrhosis or chronic hepatitis, often complicated by diabetes mellitus. In the current study, the authors evaluated the impact of diabetes mellitus on the prognosis of patients with HCC. METHODS Among 581 patients with HCC who had been diagnosed and treated between 1990 and 1999, survival was compared between those patients with and those patients without diabetes mellitus. The rate of disease recurrence after treatment also was analyzed. RESULTS Ninty-two patients (15.8%) had diabetes mellitus. There was no significant difference with regard to patient characteristics (i.e., age, gender, or alcohol intake) or liver function between those patients with and those patients without diabetes mellitus. No differences were observed in survival between patients with diabetes mellitus and patients without it. Among the 195 patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension, the survival of the 32 patients with diabetes mellitus was significantly poorer than that of the 163 patients without diabetes mellitus (P = 0.0273), despite no apparent difference in liver function between the 2 groups. On multivariate analysis, diabetes mellitus was found to be an independent factor predicting lower survival after treatment (P = 0.0077) among patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension. No difference in the rate of recurrence was observed between the two groups in all the patients and in those patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension. CONCLUSION The results of the current study indicated that the presence of diabetes mellitus worsens the prognosis of patients with a solitary HCC lesion measuring ≦ 3 cm in greatest dimension; it appears to impact prognosis in patients with HCC when HCC is treatable, based on the size and the number of lesions. However, diabetes mellitus did not appear to affect the prognosis in the general population of patients with HCC. Based on the current study data, diabetes mellitus does not appear to modify the progression of HCC and its recurrence after treatment, but it does appear to worsen the prognosis of patients with HCC by means of a rapid decline in remnant liver function caused by repeated treatment of HCC. Cancer 2001;91:957–63. © 2001 American Cancer Society.

Liver function

10.1002/1097-0142(20010301)91:5<957::aid-cncr1085>3.0.co;2-j

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Citations (59)

A CLINICAL EVALUATION OF TRANSCATHETER ARTERIAL EMBOLIZATION FOR CONTROL OF BLEEDING FROM GASTRIC ULCER

Acta gastro-enterologica belgica (1991)

Isao Takeda Satoshi Nakano Takashi Kumada Kei‐ichi Sugiyama Toshimasa Osada

Arterial Embolization

10.11280/gee1973b.33.2220

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Citations (0)

A new surgical technique (left upper abdominal evisceration) for advanced carcinoma of the gastric stump.

PubMed (1994)

Yutaka Yonemura Kei‐ichi Sugiyama Takumi Fujimura Toru Kamata T Sawa

In spite of recent advances in the early diagnosis of gastric cancer by mass screening, gastric stump cancers following gastrectomy are still diagnosed at a highly advanced stage, and the surgical results remain very poor. Involvement of the fourth level lymph node stations, local peritoneal carcinomatosis and tumor growth invading the neighboring organs are frequently observed in advanced stump cancers. With the aim of achieving complete resection of these tumors, left upper abdominal evisceration (LUAE) + R4 gastrectomy was performed in 29 patients (Group B) with stump cancer as a radical surgical procedure. The survival of these patients was compared with that of 74 patients (Group A) who underwent total gastrectomy with or without pancreaticosplenectomy. Duration of surgery blood loss, and incidence of postoperative complications were similar with the two methods. When the survival rates were compared, the 5-year-survival rate in stage IV cases was higher for Group B than for Group A. LUAE + R4 gastrectomy is a rational technique for the surgical treatment of stage IV gastric stump cancer.

Evisceration (ophthalmology)

Lymphadenectomy

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Citations (10)