Chang-Jung Chiang

Taipei Medical University-Shuang Ho Hospital

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Lien-Chen Wu

Taipei Medical University-Shuang Ho Hospital

Yang‐Hwei Tsuang

Taipei Medical University-Shuang Ho Hospital

Yueh-Ying Hsieh

Taipei Medical University-Shuang Ho Hospital

Chia-Hsien Chen

Taipei Medical University-Shuang Ho Hospital

Fon-Yih Tsuang

National Taiwan University Hospital

Yi-Jie Kuo

Taipei Medical University

Yi‐Jie Kuo

Wan Fang Hospital

Chia-Hsien Chen

Taipei Medical University-Shuang Ho Hospital

Chin-Chean Wong

Taipei Medical University

Chun-Jen Liao

Industrial Technology Research Institute

Cooperative Institutions

Taipei Medical University

Taipei Medical University-Shuang Ho Hospital

National Yang Ming Chiao Tung University

National Taiwan University

National Taiwan University Hospital

Wan Fang Hospital

National Yang Ming University Hospital

Taipei City Hospital

Taipei Medical University Hospital

Chang Gung University

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Sciatica caused by spinal epidural abscess as the initial clinical presentation of colon cancer: a rare case report and review of literature

Research Square (Research Square) (2023)

Kuan-Yu Lu Chang-Jung Chiang Yueh-Ying Hsieh Chia-Hsien Chen Mei Hui Lee

Abstract Colorectal cancer is one of the most frequently diagnosed forms of cancer, and it is associated with several common symptoms and signs. Sciatica is not considered one of these. However, in this article, we present a case of colorectal cancer manifesting symptoms of sciatica alone. The sciatica was the result of a spinal epidural abscess caused by the pathogen Streptococcus gallolyticus diagnosed by intraoperative pus culture. Although without typical signs of colorectal cancer, the presence of this pathogen prompted further tumor evaluation, ultimately leading to the discovery of a sigmoid adenocarcinoma. In rare cases, sciatica caused by S. gallolyticus infection of the spinal epidural space may serve as the initial presentation of colorectal cancer. Physicians should be aware of the strong association between S. gallolyticus and colorectal cancer. Based on what we currently know about the condition, we recommend a systematic assessment of occult neoplasia for patients with S. gallolyticus infection.

Occult

Presentation (obstetrics)

10.21203/rs.3.rs-3378411/v1

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Citations (0)

In vitro and in vivo Methods to Measure the Ceftriaxone Distribution into the Rat Tail Intervertebral Disc

Analytical Sciences (2010)

Chia-Chun Lin Yu‐Tse Wu Jiin‐Cherng Yen Chang-Jung Chiang Yang‐Hwei Tsuang

Penetration (warfare)

10.2116/analsci.26.979

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Citations (3)

Platelet-Rich Fibrin–Augmented Gap-Bridging Strategy in Rabbit Anterior Cruciate Ligament Repair

The American Journal of Sports Medicine (2023)

Pei-Wei Weng Chih‐Hwa Chen Yi‐Cheng Lin Kuan‐Hao Chen Yi-Yen Yeh

We assessed the efficacy of a novel platelet-rich fibrin (PRF)-augmented repair strategy for promoting biological healing of an anterior cruciate ligament (ACL) midsubstance tear in a rabbit model. The biological gap-bridging effect of a PRF scaffold alone or in combination with rabbit ligamentocytes on primary ACL healing was evaluated both in vitro and in vivo.A PRF matrix can be implanted as a provisional fibrin-platelet bridging scaffold at an ACL defect to facilitate functional healing.Controlled laboratory study.The biological effects of PRF on primary rabbit ligamentocyte proliferation, tenogenic differentiation, migration, and tendon-specific matrix production were investigated for treatment of cells with PRF-conditioned medium (PRFM). Three-dimensional (3D) lyophilized PRF (LPRF)-cell composite was fabricated by culturing ligamentocytes on an LPRF patch for 14 days. Cell-scaffold interactions were investigated under a scanning electron microscope and through histological analysis. An ACL midsubstance tear model was established in 3 rabbit groups: a ruptured ACL was treated with isolated suture repair in group A, whereas the primary repair was augmented with LPRF and LPRF-cell composite to bridge the gap between ruptured ends of ligaments in groups B and C, respectively. Outcomes-gross appearance, magnetic resonance imaging, and histological analysis-were evaluated in postoperative weeks 8 and 12.PRFM promoted cultured ligamentocyte proliferation, migration, and expression of tenogenic genes (type I and III collagen and tenascin). PRF was noted to upregulate cell tenogenic differentiation in terms of matrix production. In the 3D culture, viable cells formed layers at high density on the LPRF scaffold surface, with notable cell ingrowth and abundant collagenous matrix depositions. Moreover, ACL repair tissue and less articular cartilage damage were observed in knee joints in groups B and C, implying the existence of a chondroprotective phenomenon associated with PRF-augmented treatment.Our PRF-augmented strategy can facilitate the formation of stable repair tissue and thus provide gap-bridging in ACL repair.From the translational viewpoint, effective primary repair of the ACL may enable considerable advancement in therapeutic strategy for ACL injuries, particularly allowing for proprioception retention and thus improved physiological joint kinematics.

Platelet-rich fibrin

10.1177/03635465221149993

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Citations (4)

IN VIVOEVALUATION OF A NEW β-TRICALCIUM PHOSPHATE BONE SUBSTITUTE IN A RABBIT FEMUR DEFECT MODEL

Biomedical Engineering Applications Basis and Communications (2014)

Kam-Kong Chan Chia-Hsien Chen Lien-Chen Wu Yi‐Jie Kuo Chun-Jen Liao

Calcium phosphate ceramics, of a similar composition to that of mineral bone, and which possess the properties of bioactivity and osteoconductivity, have been widely used as substitutes for bone graft in orthopedic, plastic and craniofacial surgeries. A synthetic β-tricalcium phosphate, Osteocera™, a recently developed bone graft substitute, has been used in this study. To evaluate the affinity and efficacy of Osteocera™ as bone defect implant, we used a New Zealand white rabbit femur defect model to test the osteoconductivity of this new bone substitute. Alternative commercially available bone substitutes, Triosite ® and ProOsteon500, were used as the control materials. These three bone substitutes show good biocompatibility, and no abnormal inflammation either infection was seen at the implantation sites. In the histological and histomorphometric images, newly formed bone grew into the peripheral pores in the bone substitutes. After six months implantation, the volume of bone formation was found to be 20.5 ± 5.2%, 29.8 ± 6.5% and 75.5 ± 4.9% of the potential total cavity offered by ProOsteon500, Triosite ® and Osteocera™, respectively. The newly formed bone area within the femur defect section for Osteocera™ was significantly larger than ProOsteon500 and Triosite ® . We concluded that Osteocera™ shows better bioresorbability, biocompatibility and osteoconductivity in the rabbit femur defect model.

Biocompatibility

Rabbit (cipher)

Bone tissue

10.4015/s1016237215500283

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Citations (1)

Perioperative Comparison of Transforaminal Lumbar Interbody Fusion and Posterior Lumbar Interbody Fusion Using Cages for Treatment of Degenerative Lumbar Disorders

Zhōnghuá gǔkē yīxué zázhì (2009)

Chia-Hsien Chen Yi‐Jie Kuo Chang-Jung Chiang Yang‐Hwei Tsuang

Source

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Citations (1)

IN VIVO EVALUATION OF A NEW BIPHASIC CALCIUM PHOSPHATE BONE SUBSTITUTE IN RABBIT FEMUR DEFECTS MODEL

Biomedical Engineering Applications Basis and Communications (2012)

Chia-Hsien Chen Chang-Jung Chiang Gary Rau Mao-Suan Huang Kam Kong Chan

Calcium phosphate ceramic has been known for its properties of bioactivity and osteoconductivity and has been widely used in orthopedic, plastic and craniofacial surgeries. The biocompatibility, unlimited availability, lower morbidity for the patient and cost-effectiveness of calcium phosphate ceramics represent important advantages over other biological bone graft, such as autografts and allografts. A new synthetic biphasic calcium phosphate (BCP), Bicera™ (60% HA and 40% β-TCP), is manufactured by Wiltrom Co., Ltd., as a new bone graft substitute. It shows good biocompatibility without cytotoxicity in in vitro test. To evaluate the possible application for clinical use, we used New Zealand white rabbit femur defect model to compare the osteoconductivity of this new bone substitute to another commercially available bone substitute (Triosite ® ) which was used as the control material. According to the macroscopic observation, both bone substitutes show good biocompatibility and no abnormal inflammation either infection was seen at the implantation sites. X-rays image of implant sites at one month, three months and six months showed all implanted materials were well incorporated with host bone. All of them were not fully absorbed and replaced after six months implantation. In the histological and hitomorphometric data, new bone grew into the surface of the peripheral pores in both bone substitutes and increased over time. Moreover, the degree of bone regeneration appeared to be relatively greater in the specimens with Bicera™ when compared with Triosite ® . We concluded that this new synthetic BCP (Bicera™) showed similar biocompatibility and osteoconductive characteristic comparing with commercial product Triosite ® in rabbit femur defects model.

Biocompatibility

Rabbit (cipher)

Bone tissue

10.4015/s1016237212500494

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Citations (5)

Extracorporeal shockwave therapy improves short-term functional outcomes of shoulder adhesive capsulitis

Journal of Shoulder and Elbow Surgery (2014)

Chih‐Yu Chen Chia-Chian Hu Pei-Wei Weng Yu-Ming Huang Chang-Jung Chiang

Capsulitis

Extracorporeal shockwave therapy

10.1016/j.jse.2014.08.010

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Citations (57)

Complete Femoral Nerve Palsy Following Traumatic Iliacus Hematoma

JBJS Case Connector (2013)

Hsiu-Wen Kuo Jan-Wen Ku Chang-Jung Chiang Gary Rau Chih‐Yu Chen

Kuo, Hsiu-Wen MD; Ku, Jan-Wen MD; Chiang, Chang-Jung MD, PhD; Rau, Gary MD; Chen, Chih-Yu MD; Chen, Chia-Hsien MD Author Information

Femoral nerve

10.2106/jbjs.cc.l.00291

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Citations (4)

FINITE ELEMENT ANALYSIS OF CERVICAL SPINE WITH DIFFERENT CONSTRAINED TYPES OF TOTAL DISC REPLACEMENT

Journal of Mechanics in Medicine and Biology (2014)

CHIEN-YU LIN Shih‐Youeng Chuang Chang-Jung Chiang Yang‐Hwei Tsuang WENG-PIN CHEN

Various designs of cervical total disc replacement (CTDR) have been introduced and employed in an attempt to avoid disadvantages of the fusion surgery. The purposes of this study were to evaluate the effects of the range of motion (ROM), the instantaneous center of rotation (ICR) and the facet joint force (FJF) with different constrained types of CTDR devices. A three-dimensional finite element (FE) model of intact cervical spine (C3-7) was made from CT scans of a normal person and validated. Postoperative FE models simulating CTDR implantation at the C5-6 disc space were made for CTDR-I (constrained design) and CTDR-II (nonconstrained design), respectively. Hybrid protocol (intact: 1 Nm) with a compressive follower load of 73.6 N was applied at the superior endplate of the C3 vertebral body. The inferior endplate of C7 vertebral body was constrained in all directions. At the index level, CTDR-I showed a higher increase in segmental motion and FJF than CTDR-II in extension, lateral bending and axial rotation. The CTDR-II with an elastomer-type core reproduced a near physiological ICR of the intact model in extension and axial rotation. Abnormal kinetic and kinematic changes related to the CTDR may induce surgical level problems and cause long-term failure of spinal surgery.

10.1142/s0219519414500389

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Citations (7)

Removal of fixation construct could mitigate adjacent segment stress after lumbosacral fusion: A finite element analysis

Clinical Biomechanics (2017)

Yueh-Ying Hsieh Chia-Hsien Chen Fon-Yih Tsuang Lien-Chen Wu Shang‐Chih Lin

Combined usage of posterior lumbar interbody fusion and transpedicular fixation has been extensively used to treat the various lumbar degenerative disc diseases. The transpedicular fixator aims to increase stability and enhance the fusion rate. However, how the fused disc and bridged vertebrae respectively affect adjacent-segment diseases progression is not yet clear.Using a validated lumbosacral finite-element model, three variations at the L4-L5 segment were analyzed: 1) moderate disc degeneration, 2) instrumented with a stand-alone cage and pedicle screw fixators, and 3) with the cage only after fusion. The intersegmental angles, disc stresses, and facet loads were examined. Four motion tests, flexion, extension, bending, and twisting, were also simulated.The adjacent-segment disease was more severe at the cephalic segment than the caudal segment. After solid fusion and fixation, the increase in intersegmental angles, disc stresses and facet loads of the adjacent segments were about 57.6%, 47.3%, and 59.6%, respectively. However, these changes were reduced to 30.1%, 22.7%, and 27.0% after removal of the fixators. This was attributed to the differences between the biomechanical characteristics of the fusion and fixation mechanisms.Fixation superimposes a stiffer constraint on the mobility of the bridged segment than fusion. The current study suggested that the removal of spinal fixators after complete fusion could decrease the stress at adjacent segments. Through a minimally invasive procedure, we could reduce secondary damage to the paraspinal structures while removing the fixators, which is of utmost concern to surgeons.

Lumbosacral joint

Biomechanics

Degenerative Disc Disease

10.1016/j.clinbiomech.2017.02.011

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Citations (43)