Yoshiya Toyoshima

Higashi Nagoya National Hospital

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Akira Uno

Ichikawa Junior and Senior High School

Junko Kozuka

Musashino University

Shunsuke Takenaka

Kanazawa University Hospital

Masato Kaneko

Kokushikan University

Hidehiko Koeda

Iwate Medical University

Shin‐ichiro Hamano

Saitama Children's Medical Center

Hitoshi Oikawa

Iwate Medical University

Susumu MOTOYAMA

Iwate Medical University

Kunihiro Fukushima

Hayashi Eye Hospital

Toru Iwama

Gifu University

Cooperative Institutions

Iwate Medical University

National Center of Neurology and Psychiatry

Gifu University

Aizawa Hospital

University of Tsukuba

Dyslexia Foundation

Kyoto University

Saitama International Medical Center

National Institute of Mental Health

Saitama Children's Medical Center

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Recovery process in Acquired Childhood Aphasia: An analysis using the regularized scale of the Standard Language Test of Aphasia (SLTA)

Higher Brain Function Research (2004)

Akira Uno Junko Kozuka Yoshiya Toyoshima Noriko Haruhara Masato Kaneko

本報告の目的は,小児失語症の改善因子,回復の経過,障害構造に関して,限局病巣を有する失語症 18例について客観的評価法を用いて検討することである。間隔尺度化された得点法である標準失語症検査 (SLTA) 総合評価得点を指標とした。また,大脳後方に限局的な病巣を有する 8例については,病巣の大きさと場所が類似している成人失語症例と改善について比較した。その結果,改善因子としての原因疾患を比較すると,脳血管障害や外傷例は改善到達度が高く,感染症例は低かった。回復過程を言語モダリティ別に分析すると理解が先行して改善し,次に発話,書字という順番であった。また,小児失語症例は成人失語症例と比べて改善到達度が高く,早期に改善する傾向が認められた。しかし,その到達度には限界があり,成人失語症例と同様に SLTAの「口頭命令に従う」「文の復唱」や「漢字単語の書字」「漢字単語の書取」などの項目で有意な得点低下が認められた。他の認知検査結果より,音韻処理障害や言語性意味理解障害が関与している可能性が考えられた。

10.2496/hbfr.24.303

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Citations (2)

Clinical significance of hepaplastintest in hepatitis and liver cirrhosis

Blood & Vessel (1976)

I. Kaito Shunichi Sato Takashi Ishii Akio Yamashina Susumu MOTOYAMA

Hepaplastintest (HPT) was comparatively evaluated in 140 cases with liver diseases (9 fulminant hepatitis, 34 acute hepatitis, 50 chronic hepatitis and 47 liver cirrhosis), and in 31 normal subjects. The following results were obtained.1) The normal range of the activities of hepaplastintest was 80.3-134.3%.2) The activities of hepaplastintest showed a decrease in patients with hepatitis and liver cirrhosis as compared to normal subjects, especially in fulminant hepatitis and in liver cirrhosis with coma.3) In patients with hepatitis and liver cirrhosis, there was a correlation between the activity of hepaplastintest and the severity of the disease.4) An increase in PIVKA-inhibitor (more than 0.5), as an index of the complication of disseminated intravascular coagulation (DIC), was found in 1/3 of the the cases with fulminant hepatitis.Therefore, it is thought that the determination of hepaplastintest in hepatitis and liver cirrhosis is useful to determine the diagnosis and the prognosis of the diseases. Also involvement of DIC was suggested in fulminant hepatitis from the aspect of PIVKA-inhibitor.

Fulminant hepatitis

Fulminant

Liver disease

10.2491/jjsth1970.7.735

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A speech expression disorder in patients with severe diffuse brain injury who emerged from a vegetative or minimally conscious state

Brain Injury (2011)

Yoshiya Toyoshima Yoshitaka Asano Jun Shinoda Shunsuke Takenaka Tatsuki Aki

The purpose of this study was to highlight a speech expression disorder considered as a mixed speech apraxia (SA) and dysarthria syndrome in patients with chronic severe diffuse brain injury (DBI) and to determine its correlation with anatomical localizations of brain lesions using neuroimaging.Among 140 patients with chronic severe DBI, eight showed this type of speech disorder. MRI (five patients) and FDG-PET (six patients) procedures were performed.Affected patients could comprehend verbally, read words silently and express words using a word board. Compared with SA, the disorder is characterized by similarities in regards to reduced phonation and marked facio-oral apraxia, but by distinct differences in terms of an accompanying dysphagia and pyramidal/extra-pyramidal symptoms that are similar to symptoms associated with dysarthria due to pseudobulbar palsy. Diffuse regions of the white matter including the left arcuate fasciculus (AF) were significantly decreased in fractional anisotropy value. However, there was no significant cortical metabolic damage in FDG-PET.The observed speech disorder in these patients is a characteristic entity related to dysfunction of speech expression and may be attributable to damage of not only the AF but also a number of fibres that are related to dysarthria, cognitive and emotional impairments and pyramidal/extra-pyramidal symptoms.

Dysarthria

Apraxia

Speech disorder

Acquired brain injury

Diffuse axonal injury

Expression (computer science)

10.3109/02699052.2011.613087

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Citations (3)

Relationship between the change of language symptoms and the change of regional cerebral blood flow in the recovery process of two children with acquired aphasia

Brain and Development (2017)

Junko Kozuka Akira Uno Hiroshi Matsuda Yoshiya Toyoshima Shin‐ichiro Hamano

10.1016/j.braindev.2017.01.002

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Kana Reading and Writing Preferentially Impaired in a Case of Pediatric Acquired Dyslexia/Dysgraphia without Aphasia Caused by Moyamoya Disease

The Japan Journal of Logopedics and Phoniatrics (2017)

Akie Fujiyoshi Akira Uno Yoshiya Toyoshima Kunihiro Fukushima

1歳時にモヤモヤ病を発症した右利き男児において，7歳時の検査にてひらがなとカタカナの読み書き障害および視覚記憶障害と音韻認識障害が認められることが判明した．本症例と失語症を伴う後天性失読失書小児例と先天性と考えられる発達性読み書き障害報告例との比較を行った．その結果，本症例では視覚性記憶障害が合併した点が失語症を伴う後天性失読失書小児例での既報告例と異なっていると思われた．一方，発達性読み書き障害では，ひらがな，カタカナの音読が障害されると漢字音読も障害される．しかし，本症例では，ひらがな，カタカナの音読は障害されていたものの，漢字音読は正常であった点が相違点であると思われた．ひらがな，カタカナの音読の障害の背景として，本症例の視覚記憶障害と音韻認識障害が関連していた可能性が考えられた．

Dysgraphia

Kana

Moyamoya Disease

Aphasiology

10.5112/jjlp.58.22

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