Guang-lin Lu

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Zhang Mei-ji

Northwest University

Chaojun Zhu

Tianjin University of Traditional Chinese Medicine

Jianxun Dong

First Affiliated Hospital of Anhui Medical University

J. Dong

Inner Mongolia University of Technology

Luquan Ren

Jilin University

Hao Yu

Shenyang Pharmaceutical University

Yu Sheng

Beihua University

Liang Yunhong

State Key Laboratory of Automotive Simulation and Control

Jian Li

West China Hospital of Sichuan University

Ximei Tian

First Affiliated Hospital of Zhengzhou University

Cooperative Institutions

Jilin University

Jilin Medical University

First Affiliated Hospital of Anhui Medical University

Anhui Medical University

Beijing Hospital of Traditional Chinese Medicine

Tianjin University

Inner Mongolia University of Technology

Weihai Science and Technology Bureau

Liaoning Academy of Materials

Jilin Agricultural University

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[Effect of acupoint injection with bone marrow mesenchymal stem cells on the blood flow in rats with hind limb ischemia].

Zhongguo zhenjiu (2009)

Chaojun Zhu J. Dong Zhang Mei-ji Guang-lin Lu Jian Li

To investigate the best injection method of the bone marrow mesenchymal stem cells (BM-MSCs) transplantation for the treatment of a rat model with hind limb ischemia.Twenty four SD rats with hind limb ischemia were randomly divided into four groups: control group, model group, acupoint BM-MSCs injection group (API group) and thigh muscle BM-MSCs injection group (TMI group). The acupoints of "Sanyinjiao" (SP 6), "Housanli" (ST 36), "Zhaohai" (KI 6), "Huantiao" (GB 30) and "Yanglingquan" (GB 34) were selected for API group, and five non-acupoints were selected on gastrocnemius and adductor of ischemic hind limb for TMI group. Both groups were accepted BM-MSCs transplantion. Model rat with hind limb ischemia was established with the method of blocking the femoral artery and its branches. The changes of blood flow (perfuse unit, PU) was monitored with laser Doppler flowmetry (LDF). In order to describe the visual changes in blood flow, the PU index (PUI) was determined as the ratio of ischemic to non-ischemic hind limb blood perfusion. And also, the levels of VEGF,bFGF in serum were tested to analyze the immunohistochemical expression quantity of VEGF and bFGF.Comparing with the model and the TMI groups, the PUI value on 3rd, 14th and 21th days after BM-MSCs transplantation were significantly increased in the API group (P < 0.05, P < 0.01). In contrast to the model group, the VEGF,bFGF levels in serum and the immunohistochemical expression quantity of VEGF and bFGF in the API and TMI groups were significantly increased (all P < 0.01).Transplantation of BM-MSCs through the acupoint can more significantly and quickly increase the blood flow and cause the greater improvement on hind limb ischemia than that of through the way of muscle injection.

Hindlimb

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The Research of Biology Coupling Characteristics on the Shells of Haliotis discus hannai Ino

Advances in natural science/Advances in natural sciences (2010)

Xiujuan Li Liang Yunhong Ximei Tian Luquan Ren Guang-lin Lu

The surface morphologies, structures and materials of Haliotis discus hannai Ino shells were qualitatively studied by means of a stereoscopic microscope，a field emission scanning electronic microscopy, energy dispersive spectrometer and X-ray diffractometer, and abrasive particle wear was qualitatively and quantitatively studied by means of a pin-on-disc apparatus. The results showed that the outer layer surface of Haliotis discus hannai Ino shells was non-smooth and had some strumae or similar parallel convex wave. The shells of Haliotis discus hannai Ino are polycrystalline composites of calcium carbonate and proteins and glycoproteins and consist of the periostracum, prismatic and nacreous layers with calcite in the outer prismatic layer and aragonite in the inner nacreous layer. Nacreous layer is a natural composite comprised of calcium carbonate in the aragonite polymorph with organic macromolecules sandwiched in between, and the coupling of platelet interlocks and organic materials makes nacreous layer to be strong and tough.The abrasive particle wear tests showed that the abrasion resistance was different on the different parts of the shells, and the left of the shells possessed the highest abrasion resistance and the abrasion resistance of the shells was the lowest on the edge of the right. The nacreous layer possessed higher abrasion resistance than prismatic layer because of the coupling of structure and materials of nacreous layer. Key words: Haliotis discus hannai Ino shells; morphology; structure; materials; anti-wear; biological character; coupling

Abrasion (mechanical)

Haliotis discus

10.3968/j.ans.1715787020100302.018

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Influence in Shumai Capsule on Ang II induced vascular smooth muscle dell proliferation and level of NO, SOD, MDA

Zhonghua zhongyiyao zazhi (2010)

Jianxun Dong Yu Sheng Guang-lin Lu Hao Yu Zhang Mei-ji

Objective:To observe the impact of the medicated serum of Shumai Capsule and its decomposing on vascular smooth muscle cells(VSMC) proliferation induced by angiotensinⅡ(AngⅡ) and level of NO,SOD,MDA in cell culture supernatant.Methods:Tissue explant method was used for cultivating vascular smooth muscle cells,serum pharmacology was used,AngⅡ10-7mol/L as a stimulating factor,medicared serum divided into Shumai Capsule group,Huoxue Huayu decomposing group(group 1) and Bupi Yishen decomposing group(group 2),MTT colorimetric was used to test OD values,biochemical detection kit was used to test NO,SOD,MDA levels.Results:The OD value of Shumai Capsule and group1 had significant difference from AngⅡ group and group2(P0.001);NO level of AngⅡgroup and group2 was lower than that of the control group,Shumai Capsule group and group1(P0.001);SOD level of AngⅡgroup,group2 was higher than that of the control group,Shumai Capsule group and group1(P0.001);MDA level of AngⅡ group,group2 was lower than that of the control group,Shumai Capsule group and group1(P0.001) too.Conclusion:Shumai Capsule group and group 1 had the effect of inhibiting cell proliferation.by promoting the secretion of NO and MDA,limiting the expression of SOD.The inhibitory effect of Shumai Capsule and group2 were the best.

Capsule

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