Abstract Background Autism-spectrum disorder is a neurodevelopmental disorder with heterogeneity in etiopathogenesis and clinical presentation. Neuroanatomical and neurophysiological abnormalities may represent neural endophenotypes for autism spectrum disorders which may help identify subgroups of patients seemingly similar in clinical presentation yet different in their pathophysiological underpinnings. Furthermore, a thorough understanding of the pathophysiology of disease can pave the way to effective treatments, prevention, and prognostic predictions. The aim of this review is to identify the predominant neural endophenotypes in autism-spectrum disorder. The evidence was researched at the following electronic databases: Pubmed, PsycINFO, Scopus, Web of Science, and EMBASE. Results Enlarged brain, especially frontotemporal cortices have been consistently reported by structural neuroimaging, whereas functional neuroimaging has revealed frontotemporal dysconnectivity. Conclusions Regrettably, many of these findings have not been consistent. Therefore, translating these findings into neural endophenotype is by far an attempt in its budding stage. The structural and functional neuroimaging changes may represent neural endophenotypes unique to autism-spectrum disorder. Despite inconsistent results, a clinically meaningful finding may require combined efforts of autism-spectrum-disorder researchers focused on different aspects of basic, genetic, neuroimaging, and clinical research.
Abstract Introduction Research on sexual satisfaction, especially orgasm, has focused on North American and Western contexts. Studies show women frequently pretend during PVI to end activity or avoid consequences. Reasons vary from emotional communication to mate deception, not always related to sexual dysfunctions. Sociosexuality may influence behaviors, with casual sex individuals less likely to fake orgasms for positive feedback. Limited research on non-Western societies, especially Egypt, prompted this study to explore prevalence and reasons for pretending orgasm among Egyptian women, investigating correlations with sexual orientation, sexual violence history, dysfunction, and family size. Objective 1. Prevalence of faking orgasm in Egyptian adults. 2. Reasons for faking orgasm in Egyptian women. 3. Correlations with sexual orientation, violence history, dysfunction, and family size. 4. Insights into sexual scripts in Egyptian society. Methods This cross-sectional survey investigates reasons for faking orgasm in Egyptian women. A convenience sample of women aged 18 and above was recruited through social media, community centers, and universities. Data collection occurred between [December 2020] and [February 2021], with participants providing informed consent for the online survey. The survey includes 51 questions on pretending orgasm and a structured interview for demographic information. Participants rated reasons on a Likert scale, and quantitative data will be analyzed using descriptive and inferential statistics to identify prevailing motives. Results In the survey of 626 Egyptian women: •38.6% (242 women) reported pretending orgasm during sexual encounters. •Common reasons for pretending included: wanting to end sexual activity (55.9%–350 women), avoiding negative consequences (66.6%–417 women), and pleasing their partner (55.9%–350 women). •Sociosexuality played a role, with 38.3% (240 women) of those interested in casual sex less likely to fake orgasms for positive feedback. •96.2% (602 women) identified as heterosexual, 1% (6 women) as homosexual, and 2.9% (18 women) as bisexual. •85.2% (534 women) were married, 6.4% (40 women) divorced, 2.6% (16 women) separated, and 5.7% (36 women) in a relationship. •91.8% (575 women) belonged to small families, and 8.2% (51 women) to big families. •14.1% (88 women) had multiple sexual partners, and 16.5% (103 women) suffered from psychological dysfunction. •43.2% (271 women) engaged in sexual relationships more than once a week, 26.9% (168 women) once a week, and 17.6% (110 women) once a month. •32.6% (204 women) were sexually satisfied, 9.6% (60 women) were not satisfied, and 7% (44 women) were neutral. •45.5% (285 women) had a history of sexual harassment, and 27.6% (173 women) had a history of Female Genital Mutilation (FMG). Conclusions The study reveals a prevalent practice of pretending orgasm among Egyptian women (38.6%). Reasons for pretending vary, with a significant percentage aiming to end sexual activity (55.9%), avoid negative consequences (66.6%), and please partners (55.9%). Sociosexuality plays a role, with 38.3% of those interested in casual sex less likely to fake orgasms for positive feedback. Findings emphasize open communication for sexual satisfaction and relationship well-being. Limitations include self-report bias and limited generalizability. Future research should explore diverse contexts and long-term effects on relationship satisfaction. Addressing complexities is vital for healthy relationships among Egyptian women. Disclosure No.
The COVID-19 pandemic is rapidly spreading, and health care systems are being overwhelmed with the huge number of cases, with a good number of cases requiring intensive care. It has become imperative to develop safe and effective treatment strategies to improve survival. In this regard, understanding the pathogenesis of COVID-19 is highly important. Many hypotheses have been proposed, including the ACE/angiotensin-II/angiotensin receptor 1 pathway, the complement pathway, and the angiotensin-converting enzyme 2/mitochondrial assembly receptor (ACE2/MasR) pathway. SARS-CoV-2 binds to the ACE2 on the cell surface, downregulating the ACE2, and thus impairs the inactivation of bradykinin and des-Arg9-bradykinin. Bradykinin, a linear nonapeptide, is extensively distributed in plasma and different tissues. Kininogens in plasma and tissue are the main sources of the two vasoactive peptides called bradykinin and kallidin. However, the role of the dysregulated bradykinin pathway is less explored in the pathogenesis of COVID-19. Understanding the pathogenesis of COVID-19 is crucial for the development of new effective treatment approaches which interfere with these pathways. In this review, we have tried to explore the interaction between SARS-CoV-2, ACE2, bradykinin, and its metabolite des-Arg9-bradykinin in the pathogenesis of COVID-19.
Background: With the increasing age, the body undergoes several physical and psychiatric changes; it is important to address the healthcare management apprehensions among the elderly and promote geriatric rehabilitation care both socially and economically. Objective: To evaluate the need for rehabilitation amongthe geriatric population living in Pakistan. Design: Cross-sectional study Place and Duration of Study: Department of Medicine, Liaquat National Hospital, Karachi from 1st January 2020 to 30th June 2020 Methodology: One hundred and three geriatric subjects aged between 65 to 90 years were enrolled. The data were collected using a structured questionnaire designed to obtain information regarding home care and geriatric rehabilitation care. Results: Sixty (58.2%) were females and 43 (41.7%) were males. The majority were <80 years of age, 82 (79.6%). Around 52 (50.5%) subjects knew about rehabilitation care and most believed that geriatric rehabilitation care is beneficial. Sixty four (62.1%) subjects were involved in socialization once a week, 29 (28.2%) once in a month, 6 (5.8%) biannually and 4 (3.9%) marked not at all. Among all, 41% reported being isolated, and 86% were getting enough psychiatric/physical care at home. Conclusion: Although 52 (50.5%) of the study subjects reported knowing geriatric rehabilitation care, due to limited resources and economic constraints in Pakistan, we have been unable to set up centers to rehabilitate the elderly. There is a need to design and conduct rehabilitation programs to control morbidity and improve the quality of the geriatric population. Keywords: Geriatric rehabilitation care (GRC), Home care, Geriatric population
Vitamin D is a neurosteroid hormone that regulates neurotransmitters and neurotrophins. It has anti-inflammatory, antioxidant, and neuroprotective properties. It increases neurotrophic factors such as nerve growth factor which further promotes brain health. Moreover, it is also helpful in the prevention of amyloid accumulation and promotes amyloid clearance. Emerging evidence suggests its role in the reduction of Alzheimer’s disease hallmarks such as amyloid-beta and phosphorylated tau. Many preclinical studies have supported the hypothesis that vitamin D leads to attentional, behavioral problems and cognitive impairment. Cross-sectional studies have consistently found that vitamin D levels are significantly low in individuals with Alzheimer’s disease and cognitive impairment compared to healthy adults. Longitudinal studies and meta-analysis have also exhibited an association of low vitamin D with cognitive impairment and Alzheimer’s disease. Despite such evidence, the causal association cannot be sufficiently answered. In contrast to observational studies, findings from interventional studies have produced mixed results on the role of vitamin D supplementation in the prevention and treatment of cognitive impairment and dementia. The biggest issue of the existing RCTs is their small sample size, lack of consensus over the dose, and age of initiation of vitamin D supplements to prevent cognitive impairment. Therefore, there is a need for large double-blind randomized control trials to assess the benefits of vitamin D supplementation in the prevention and treatment of cognitive impairment.
Acute myelogenous leukemia (AML) is a clonal, malignant disease of hematopoietic tissue that is characterized by accumulation of abnormal (leukemic) blast cells, principally in the bone marrow. Representation of these genetic mutations and the involvement patterns seems to follow specific and temporally ordered fluctuating manners. Somatic mutations in these genes are represented as a variety of recurrent chromosomal abnormalities, e.g., t (8;21), t(15;17), etc., or by the presence of prognostic markers, e.g., FLT3, MLL, NPM1 and CEBPA as well as encoding epigenetic modifiers, such as DNMT3A, ASXL1, TET2, IDH1, and IDH2, are commonly acquired early and are present in the founding clone. The same genes are frequently found to be mutated in elderly individuals along with clonal expansion of hematopoiesis that confers an increased risk for the development of hematologic cancers. Furthermore, such genomic changes may persist after therapy, lead to clonal expansion during hematologic remission, and eventually lead to relapsed disease. Majority of genetic data are now being used to classification, risk stratification, and clinical care of patients. The unprecedented molecular characterization provided by advanced and deeply sensitized molecular assays like next-generation sequencing (NGS) offers the potential for an individualized approach to treatment in AML, bringing us one step closer to personalized medicine.
ABSTRACT: The relative failure of symptomatic therapeutic trials for Alzheimer's disease using non-selective cholinergic agonists brings about the need for longitudinal studies with parallel designs aimed at disease stabilization, using trophic substances or amyloid suppressors.
Abstract Background The precise choice of specialty is of paramount importance in a physician’s career. Several factors play a role in deciding the specialty, such as intelligence, motivation, clinical experience, personality, and socioeconomic factors. Our hypothesis is whether personality profiles differ based on specialty choice. Therefore, we investigated the association between personality traits and specialty choice. Results A cross-sectional study was conducted among 379 undergraduate medical students. Big five personality inventory was used to determine the personality traits among medical students. The most chosen speciality among both male and females was Surgery. Comparing the groups depending on their preferred specialties revealed no differences in three of five personality traits of Big five personality inventory. Students who selected psychiatry specialty scored highest on openness ( p = 0.007) and lowest on extraversion ( p = 0.018), indicating a substantial difference between the traits of extraversion and openness to experience. Conclusions The differences in personality features could not be attributed to a predilection for a particular speciality. However, medical students who scored higher on openness (intellect/imagination) and less on extraversion scales were more likely to choose psychiatric specialty. Numerous other factors affect specialization preference even if there are no differences in personality features between various specialties.
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