Qingyu Meng

China Automotive Technology and Research Center

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Pamela Ohman‐Strickland

Rutgers, The State University of New Jersey

Stephan Schwander

Rutgers, The State University of New Jersey

Yeongkwon Son

Desert Research Institute

Junfeng Zhang

Duke Institute for Health Innovation

Cristine D. Delnevo

Rutgers, The State University of New Jersey

Lauren Tuttle

The University of Texas at Austin

Howard M. Kipen

Environmental and Occupational Health Sciences Institute

Jennifer Richmond‐Bryant

North Carolina State University

Clifford P. Weisel

Rutgers, The State University of New Jersey

Mark G. Robson

Rutgers, The State University of New Jersey

Cooperative Institutions

Rutgers, The State University of New Jersey

Environmental and Occupational Health Sciences Institute

Environmental Protection Agency

Research Triangle Park Foundation

Johnson University

Rutgers Sexual and Reproductive Health and Rights

University of North Carolina at Chapel Hill

National Center for Environmental Assessment (EPA)

Chinese Academy of Sciences

New Jersey Department of Environmental Protection

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Sorption phenomena of PCBs in environment

Chinese Science Bulletin (2001)

Qingyu Meng Shaogang Chu Xiaobai Xu

10.1007/bf03186999

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Citations (8)

Madecassoside Isolated fromCentella asiaticaHerbs Facilitates Burn Wound Healing in Mice

Planta Medica (2008)

Mei Liu Yue Dai Ying Li Yubin Luo Fang Huang

The current study was designed to investigate the effect of madecassoside, the major triterpene in CENTELLA ASIATICA, on burn wound healing and its possible mechanism of action. An oral administration of madecassoside (6, 12, 24 mg/kg) facilitated wound closure in a time-dependent manner and reached its peak effect, nearly completely wound closure, on day 20 in the group receiving the highest dose of 24 mg/kg of madecassoside. Further histopathological analysis revealed that madecassoside alleviated infiltration of inflammatory cells as well as enhanced epithelisation resulting from dermal proliferation of fibroblasts. Madecassoside at higher doses (12 and 24 mg/kg) decreased nitric oxide (NO) levels and malondialdehyde (MDA) content in the burn skin tissue. However, reduced glutathione (GSH) and hydroxyproline levels were increased in the same skin tissue. In addition, madecassoside promoted skin angiogenesis IN VIVO, correlating with our findings IN VITRO that it stimulated endothelial cell growth in a rat aortic ring assay. These data suggest that madecassoside has significant wound-healing activity and is one of the major reasons for the use of C. ASIATICA herbs in the successful treatment of burn injury. Moreover, the results from the present study indicate that the effect of madecassoside on wound healing may involve several mechanisms including antioxidative activity, collagen synthesis and angiogenesis.

Centella

Hydroxyproline

10.1055/s-2008-1074533

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Citations (126)

Determinants of the associations between ambient concentrations and personal exposures to ambient PM2.5, NO2, and O3 during DEARS

Atmospheric Environment (2012)

Qingyu Meng Ronald Williams Joseph P. Pinto

10.1016/j.atmosenv.2012.09.019

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Citations (32)

Sorption thermodynamics and kinetics properties of tylosin and sulfamethazine on goethite

Chemical Engineering Journal (2013)

Xuetao Guo Chen Yang Zhi Dang Qian Zhang Yanjie Li

Endothermic process

10.1016/j.cej.2013.02.115

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Citations (103)

Acute exposure to elevated PM2.5 generated by traffic and cardiopulmonary health effects in healthy older adults

Journal of Exposure Science & Environmental Epidemiology (2008)

Zhihua Fan Qingyu Meng Clifford P. Weisel Robert Laumbach Pamela Ohman‐Strickland

10.1038/jes.2008.46

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Citations (58)

Variability in the fraction of ambient fine particulate matter found indoors and observed heterogeneity in health effect estimates

Journal of Exposure Science & Environmental Epidemiology (2012)

Natasha Hodas Qingyu Meng Melissa M. Lunden David Q. Rich Halûk Özkaynak

Spatial heterogeneity

Health effect

10.1038/jes.2012.34

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Citations (57)

Ambient Particulate Matter Air Pollution in Mpererwe District, Kampala, Uganda: A Pilot Study

Journal of Environmental and Public Health (2014)

Stephan Schwander Clement Dove Okello Juergen Freers Judith C. Chow John G. Watson

Air quality in Kampala, the capital of Uganda, has deteriorated significantly in the past two decades. We made spot measurements in Mpererwe district for airborne particulate matter PM 2.5 (fine particles) and coarse particles. PM was collected on Teflon-membrane filters and analyzed for mass, 51 elements, 3 anions, and 5 cations. Both fine and coarse particle concentrations were above 100 µg/m 3 in all the samples collected. Markers for crustal/soil (e.g., Si and Al) were the most abundant in the PM 2.5 fraction, followed by primary combustion products from biomass burning and incinerator emissions (e.g., K and Cl). Over 90% of the measured PM 2.5 mass can be explained by crustal species (41% and 59%) and carbonaceous aerosol (33%–55%). Crustal elements dominated the coarse particles collected from Kampala. The results of this pilot study are indicative of unhealthy air and suggest that exposure to ambient air in Kampala may increase the burden of environmentally induced cardiovascular, metabolic, and respiratory diseases including infections. Greater awareness and more extensive research are required to confirm our findings, to identify personal exposure and pollution sources, and to develop air quality management plans and policies to protect public health.

Mass concentration (chemistry)

Capital city

10.1155/2014/763934

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Citations (34)

Investigating E-Cigarette Particle Emissions and Human Airway Depositions under Various E-Cigarette-Use Conditions

Chemical Research in Toxicology (2019)

Yeongkwon Son Gediminas Mainelis Cristine D. Delnevo Olivia A Wackowski Stephan Schwander

E-cigarette use is dramatically increasing, particularly with adolescents. While the chemical composition of e-liquids and e-vapor is well characterized, the particle size distribution and the human airways deposition patterns of e-cigarette particles are understudied and poorly understood despite their likely contribution to adverse health effects from e-cigarette usage. In this study, we examined the impacts of e-cigarette device power, e-liquid composition, and vaping topography on e-cigarette particle sizes and their deposition in human airways. In addition, we observed that particle measurement conditions (dilution ratio, temperature, and humidity) significantly affect measured e-cigarette particle sizes. E-cigarette power output significantly increased particle count median diameters (CMD) from 174 ± 13 (particles generated under 6.4 W) to 236 ± 14 nm (particles generated under 31.1 W). E-cigarette particles generated from propylene glycol-based e-liquids (CMD = 145 ± 8 nm and mass median diameter [MMD] = 3.06 ± 0.17 μm) were smaller than those generated from vegetable glycerin-based e-liquids (CMD = 182 ± 9 nm and MMD = 3.37 ± 0.21 μm). Puff volume also impacted vapor particle size: CMD and MMD were 154 ± 11 nm and 3.50 ± 0.27 μm, 163 ± 6 nm and 3.35 ± 0.24 μm, and 146 ± 12 nm and 2.95 ± 0.14 μm, respectively, for 35, 90, and 170 mL puffs. Estimated e-cigarette particle mass deposition fractions in tracheobronchial and bronchoalveolar regions were 0.504-0.541 and 0.073-0.306, respectively. Interestingly, e-cigarette particles are smaller than the particles generated from cigarette smoking but have similar human airway deposition patterns.

Electronic cigarette

Particle (ecology)

Deposition

10.1021/acs.chemrestox.9b00243

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Citations (39)

Assessment of Non-Occupational 1,4-Dioxane Exposure Pathways from Drinking Water and Product Use

Environmental Science & Technology (2022)

Daniel E. Dawson Hunter A. Fisher Abigail E. Noble Qingyu Meng Anne Cooper Doherty

1,4-Dioxane is a persistent and mobile organic chemical that has been found by the United States Environmental Protection Agency (USEPA) to be an unreasonable risk to human health in some occupational contexts. 1,4-Dioxane is released into the environment as industrial waste and occurs in some personal-care products as an unintended byproduct. However, limited exposure assessments have been conducted outside of an occupational context. In this study, the USEPA simulation modeling tool, Stochastic Human Exposure and Dose Simulator-High Throughput (SHEDS-HT), was adapted to estimate the exposure and chemical mass released down the drain (DTD) from drinking water consumption and product use. 1,4-Dioxane concentrations measured in drinking water and consumer products were used by SHEDS-HT to evaluate and compare the contributions of these sources to exposure and mass released DTD. Modeling results showed that compared to people whose daily per capita exposure came from only products (2.29 × 10–7 to 2.92 × 10–7 mg/kg/day), people exposed to both contaminated water and product use had higher per capita median exposures (1.90 × 10–6 to 4.27 × 10–6 mg/kg/day), with exposure mass primarily attributable to water consumption (75–91%). Last, we demonstrate through simulation that while a potential regulatory action could broadly reduce DTD release, the proportional reduction in exposure would be most significant for people with no or low water contamination.

10.1021/acs.est.1c06996

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Citations (12)

Informed substitution of hazardous chemicals through the lens of California's Safer Consumer Products Alternatives Analysis: Best practices, challenges, and opportunities

Integrated Environmental Assessment and Management (2021)

Kelly A. Grant Lynn Nakayama Wong Qingyu Meng Heather Lee Diana S.C. Phelps

Abstract California adopted the Safer Consumer Products (SCP) regulations in 2013, which mandate that companies that manufacture specific products containing designated chemicals of concern complete an Alternatives Analysis. Alternatives Analysis is a process to avoid regrettable substitution by identifying, comparing, and selecting safer alternatives based on technical functions, hazards, exposure pathways, life‐cycle multimedia impacts, and economic impacts. The SCP Alternatives Analysis builds upon and expands existing frameworks for alternatives assessments (AAs). The aim of this study was to identify practices from AA that facilitate the robust assessment of alternatives and that align with SCP requirements and identify gaps in the practice. We evaluated completed AAs for methods regarding transparency and careful documentation of information sources, data gaps, uncertainty, criteria, and justification for decision‐making. The AAs in this review demonstrate some of the challenges in the field. Most AAs have a constrained scope and only consider chemical substitutes rather than a broad array of functional alternatives. Their scopes were also limited in the hazard endpoints that were evaluated. This was most noted with ecotoxicity endpoints, which were generally confined to aquatic toxicity. The majority of AAs do not explicitly explain their decision‐making methods or adequately discuss tradeoffs across the adverse impacts. The AAs also lack the analysis in the exposure, life‐cycle impacts, and economic impacts that are required in the SCP Alternatives Analysis process. Further, we recommend strategies and research opportunities to address these challenges and strengthen the practice of AAs. Integr Environ Assess Manag 2022;18:1007–1019. © 2021 SETAC

SAFER

Scope (computer science)

Mandate

Best practice

10.1002/ieam.4527

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Citations (6)