Mariana Camargo

Universidade Federal de São Paulo

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Ricardo Pimenta Bertolla

Universidade Federal de São Paulo

Paula Intasqui

Universidade Federal de São Paulo

Mariana Pereira Antoniassi

Universidade Federal de São Paulo

Valdemir Melechco Carvalho

Fleury S.A. (Brazil)

Karina Helena Morais Cardozo

Fleury S.A. (Brazil)

Larissa Berloffa Belardin

Centre hospitalier universitaire de Québec

A.P. Cedenho

Universidade Federal de São Paulo

Daniel Suslik Zylbersztejn

Hospital Israelita Albert Einstein

Renato Fraietta

Universidade Federal de São Paulo

D.M. Spaine

Universidade Federal de São Paulo

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Universidade Federal de São Paulo

Universidade de São Paulo

Hospital São Paulo

Universidade Estadual de Campinas (UNICAMP)

Universidade Federal do ABC

Universidade Brasil

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Norte do Paraná

University of Miami

Universidade Estadual de Londrina

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Antioxidant enzyme profile and lipid peroxidation products in semen samples of testicular germ cell tumor patients submitted to orchiectomy

International braz j urol (2017)

Camila Sposito Mariana Camargo D.S. Tibaldi Valéria Barradas A.P. Cedenho

Purpose To determine enzymatic antioxidant and lipid peroxidation levels in seminal plasma of patients orchiectomized for testicular tumors. Materials and Methods The study included 52 patients: 26 control men and 26 orchiectomized patients for testicular tumor, of which 12 men had seminoma tumor and 14 men non-seminoma tumor. After semen analysis performed according to the WHO guidelines, an aliquot of semen was centrifuged and the seminal plasma was collected. Lipid peroxidation was performed by thiobarbituric acid reactive substances (TBARS) assay and antioxidant profile was assessed by analyzing catalase, glutathione peroxidase (GPx) and superoxide anion (SOD) activities using colorimetric assays with a standard spectrophotometer. Data were tested for normality and compared using one-way ANOVA (p<0.05). Results Seminoma and non-seminoma groups presented lower sperm concentration and morphology when compared to control group (p=0.0001). Both study groups (seminoma and non-seminoma) presented higher TBARS levels when compared to control group (p=0.0000013). No differences were observed for SOD (p=0.646) andGPx (p=0.328). It was not possible to access the enzymatic activity of catalase in any group. Conclusion Patients with testicular tumor present increased semen oxidative stress, but no differences were observed in antioxidant levels, even after orchiectomy. This indicates that most likely an increased generation of oxidative products takes place in these patients.

TBARS

Orchiectomy

10.1590/s1677-5538.ibju.2016.0323

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Citations (17)

Mechanisms for sperm mitochondrial removal in embryos

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (2020)

Karla P. Melo Mariana Camargo

10.1016/j.bbamcr.2020.118916

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Principais Testes Laboratoriais Utilizados no Diagnóstico da Beta Talassemia no Brasil e no Paraguai

Caroline Gasques Paschoalinoto Raygleise dos Santos Borges Filipe de Carvalho Emery Ferreira Ana Julia Custodio Luciandra Macedo de Toledo

10.51473/ed.al.sfp4

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Proteomic profile of seminal plasma in adolescents and adults with treated and untreated varicocele

Asian Journal of Andrology (2015)

Ricardo Pimenta Bertolla Mariana Camargo Paula Intasqui

Varicocele, the most important treatable cause of male infertility, is present in 15% of adult males, 35% of men with primary infertility, and 80% of men with secondary infertility. On the other hand, 80% of these men will not present infertility. Therefore, there is a need to differentiate a varicocele that is exerting a deleterious effect that is treatable from a "silent" varicocele. Despite the growing evidence of the cellular effects of varicocele, its underlying molecular mechanisms are still eluding. Proteomics has become a promising area to determine the reproductive biology of semen as well as to improve diagnosis of male infertility. This review aims to discuss the state-of-art in seminal plasma proteomics in patients with varicocele to discuss the challenges in undertaking these studies, as well as the future outlook derived from the growing body of evidence on the seminal proteome.

Proteome

10.4103/1008-682x.168788

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Citations (31)

A real-life study of elexacaftor-tezacaftor-ivacaftor therapy in people with cystic fibrosis in Brazil

Pulmonology (2023)

L.Z. Salomão Rodrigo Abensur Athanazio Samia Zahi Rached Miquéias Lopes‐Pacheco Mariana Camargo

Ivacaftor

10.1016/j.pulmoe.2023.03.008

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Unraveling the sperm proteome and post-genomic pathways associated with sperm nuclear DNA fragmentation

Journal of Assisted Reproduction and Genetics (2013)

Paula Intasqui Mariana Camargo P.T. Del Giudice D.M. Spaine Valdemir Melechco Carvalho

Proteome

Fragmentation

Comet Assay

Shotgun proteomics

10.1007/s10815-013-0054-6

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Citations (64)

Proteomic insight of seminal plasma in spinal cord injured men submitted to oral probenecid treatment for improved motility

Journal of Spinal Cord Medicine (2020)

Mariana Camargo Emad Ibrahim Teodoro C. Aballa Karina Helena Morais Cardozo Valdemir Melechco Carvalho

Objective To observe the seminal plasma proteomic composition in men with spinal cord injury orally treated with probenecid, in order to observe pathways associated with increased sperm motility.

Probenecid

10.1080/10790268.2020.1722937

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Author Correction: Semen levels of matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) protein families members in men with high and low sperm DNA fragmentation

Scientific Reports (2019)

Larissa Berloffa Belardin Mariana Pereira Antoniassi Mariana Camargo Paula Intasqui Renato Fraietta

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

Fragmentation

10.1038/s41598-019-45361-2

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Citations (3)

Molecular pathways of varicocele and its repair – A paired labelled shotgun proteomics approach

Journal of Proteomics (2019)

Mariana Camargo Paula Intasqui Larissa Berloffa Belardin Mariana Pereira Antoniassi Karina Helena Morais Cardozo

Semen quality

Semen Analysis

10.1016/j.jprot.2019.01.019

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Citations (24)

Diagnóstico de angioedema hereditario después de treinta años de manifestaciones clínicas

Deleted Journal (2021)

Luíz Leite Ana Luisa Silveira Vieira Mariana Camargo Tainá Mosca Wilma Carvalho Neves Forte

Diagnosis and treatment of hereditary angioedema (HAE) are necessary to improve the quality of life and even the survival of patients.A 52-year-old woman with angioedema for 30 years, which affects the face, tongue, and hands. It is asymmetric, with neither pruritus nor urticaria, without response to antihistamines or corticosteroids, with spontaneous resolution in 48 hours to 72 hours; with a family history of angioedema. Normal physical examination between exacerbations. Autoimmune and lymphoproliferative diseases were ruled out. Values of C1q, C4, C1-INH were normal. The diagnosis of HAE type C1-INH normal subtype Unknown was established. The total resolution of the crises was achieved after two months with androgen therapy. Outpatient follow-up has been given for four years and no angioedema crisis has been reported, which is associated with a radical change in the quality of life.The patient was diagnosed with HAE after 30 years of clinical manifestations, after acquired angioedema was ruled out.Introducción: El diagnóstico y tratamiento del angioedema hereditario (AEH) son necesarios para mejorar la calidad de vida e incluso la supervivencia de pacientes. Reporte de caso: Mujer de 52 años con angioedema desde hace 30 años, que afecta cara, lengua y manos, asimétrico, sin prurito ni urticaria, sin respuesta a antihistamínicos ni corticoides, resolución espontánea entre las 48 a 72 horas, historia familiar de angioedema. Examen físico normal entre las exacerbaciones. Se descartaron enfermedades autoinmunes, linfoproliferativas. Los valores de C1q, C4, C1-INH fueron normales. Diagnóstico de AEH tipo C1-INH normal subtipo unknown. Tratamiento iniciado con andrógenos: resolución total de las crisis a los dos meses. Seguimiento ambulatorio durante cuatro años, sin crisis de angioedema, asociado con un cambio total en la calidad de vida. Conclusiones: La paciente fue diagnosticada de AEH solo después de 30 años de manifestaciones clínicas, después de descartar angioedema adquirido.

10.29262/ram.v68i3.874

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